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| Number | Title | Issue Date |
| 8153828 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the inv... | 04/10/2012 |
| 8138359 | Stabilized 3-hydroxyflavan compositions and methods therefor Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towa... | 03/20/2012 |
| 8080675 | Chroman derivatives, medicaments and use in therapy Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described. ... | 12/20/2011 |
| 7982058 | Chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be... | 07/19/2011 |
| 7960573 | Method for enantioselective hydrogenation of chromenes A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a c... | 06/14/2011 |
| 7906660 | Production of isoflavone derivatives Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing phar... | 03/15/2011 |
| 7863466 | Method of producing proanthocyanidin-containing material The method for producing proanthocyanidin-containing product of the present invention comprises the steps of providing a pine bark as a starting material, extracting the pine bark with at least one of water and an organic solvent, and treating the resultant extract ... | 01/04/2011 |
| 7820835 | Method for producing flavan derivatives The present invention provides a method for producing flavan derivatives having various substituent groups with controlling the stereochemistry. The method of the present invention includes the steps of: hydratively condensing a phenol compound expressed by formula ... | 10/26/2010 |
| 7786315 | Process for selectively extracting procyanidins A process is described for selectively extracting cocoa procyanidins from an aqueous mixture of cocoa polyphenols by using a particular sequence of solvents to extract selected procyanidin monomers and/or oligomers. The solvents are n-butyl acetate, ethyl acetate, m... | 08/31/2010 |
| 7714150 | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2-chroman-6-yl derivatives Compounds corresponding to formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n have the meanings giv... | 05/11/2010 |
| 7671220 | Processes for the 3,3-dialkylation of 4-chromanones The present invention relates to methods for the preparation of 3,3-dialky 4-chromanones, and particularly to the preparation of 6-fluoro-3,3-dimethyl-2,3-dihydro-4H-chromen-4-one and 3,3-dimethyl-2,3-dihydro-4H-chromen-4-one. In some embodiments, the processes incl... | 03/02/2010 |
| 7547794 | Compositions useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, ... | 06/16/2009 |
| 7544816 | (−)-Epigallocatechin gallate derivatives for inhibiting proteasome (−)-EGCG, the most abundant catechin, was found to be chemopreventive and anticancer agent. However, (−)-EGCG has at least one limitation: it gives poor bioavailability. This invention provides compounds of generally formula 10, wherein R1 is selected... | 06/09/2009 |
| 7534903 | Use of amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2-chromen-6-yl-compounds in the treatment of cardiac arrhythmia and other disease states The use of compounds corresponding to formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the description for treating cardiac arrhythmi... | 05/19/2009 |
| 7528267 | Method for enantioselective hydrogenation of chromenes A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a c... | 05/05/2009 |
| 7468445 | Antigiardial agents and use thereof The present invention provides a method of preventing or treating one or more of the following medical conditions, or treating symptoms of one or more of the following medical conditions: amebic infections, giardiasis, estrogen deficient states, osteoporosis, cardio... | 12/23/2008 |
| 7435722 | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and ... | 10/14/2008 |
| 7429411 | Chroman compound, liquid crystal composition including the compound and liquid crystal display element including the liquid crystal composition The compound (1) according to the invention has general solid-state properties necessary for a compound, stability against heat, light and the like, a suitable optical anisotropy, a suitable dielectric anisotropy, and excellent compatibility with other liquid crysta... | 09/30/2008 |
| 7396855 | Compositions and products containing S-equol, and methods for their making A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, p... | 07/08/2008 |
| 7368582 | Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them Compounds corresponding to formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the description; a process for the preparation of these c... | 05/06/2008 |
| 7361774 | Chalcone compound The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to fo... | 04/22/2008 |
| 7329687 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) | 02/12/2008 |
| 7282598 | Synthetic methods for preparing procyanidin oligomers Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially pro... | 10/16/2007 |
| 7271193 | Inhibitors of cyclin-dependent kinases and their use The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3 | 09/18/2007 |
| 7268240 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 09/11/2007 |
| 7247355 | Liquid crystal compound having chroman ring, liquid crystal composition comprising the compound and liquid crystal display device comprising the composition The present invention relates to a compound having a chroman ring, which has good thermal and optical stability, adequate optical anisotropy, adequate dielectric anisotropy and superior compatibility with other liquid crystal compounds, a liquid crystal composition ... | 07/24/2007 |
| 7244763 | Compounds that modulate PPAR activity and methods of preparation This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic... | 07/17/2007 |
| 7244855 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins Various processes are disclosed for preparing procyanidin oligomers having (4,8)-interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or -catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activated-epicatechin or -catechin... | 07/17/2007 |
| 7232663 | Assays employing novel substrates for measuring P450-mediated -dealkylation Methods and compositions for measuring N-dealkylating activity of cytochromes P450 enyzmes are disclosed. ... | 06/19/2007 |
| 7226918 | DNA-PK inhibitors The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are indepen... | 06/05/2007 |
| 7226644 | Chroman derivative and liquid-crystal composition containing the compound The present invention relates to a liquid crystal compound which has negative dielectric anisotropy and a large absolute value thereof; and a liquid crystal display element which contains the compound as a constituent element and has a negative value of dielectric a... | 06/05/2007 |
| 7214706 | Chroman derivatives as estrogenic compounds The invention provides chroman compounds having Formula (1), wherein R1 is (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skele... | 05/08/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7138429 | Flavonoid compound and process for producing the same A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial fermentation treatment with Aspergillus saitoi. ... | 11/21/2006 |
| 7126014 | Synthesis of epecatechin-4α, 8-epicatechin and -catechin dimers and derivatives thereof Oligomeric procyanidins containing 4α-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4α,8-epicatechin, by reaction of th... | 10/24/2006 |
| 7122573 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) | 10/17/2006 |
| 7109327 | Total synthesis of galanthamine, analogues and derivatives thereof The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form ═O, R3, R4 | 09/19/2006 |
| 7109236 | Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) | 09/19/2006 |
| 7102020 | Total synthesis of daurichromenic acid The present invention provides a method to prepare 2H-benzo[6]pyrans, such as the anti-HIV natural product daurichromenic acid (1a), by microwave-assisted tandem aldol reaction of a phenolic enolate followed by intramolecular SN2′ type cyclization to form the 2H-b... | 09/05/2006 |
| 7071341 | α-Glucosidase inhibitors and their synthesis from a natural source The present invention provides novel α-glucosidase inhibitory compound (−)-mesquitol and its analogs isolated in significant yield from traditional medicinal plant Dichrostachys cinerea and further modification of (−)-mesquitol to enhance the α-glucosid... | 07/04/2006 |
