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| Number | Title | Issue Date |
| 8030504 | Antagonists of the TRPV1 receptor and uses thereof The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y | 10/04/2011 |
| 7960572 | Process for preparing nebivolol The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol. ... | 06/14/2011 |
| 7435722 | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and ... | 10/14/2008 |
| 7429411 | Chroman compound, liquid crystal composition including the compound and liquid crystal display element including the liquid crystal composition The compound (1) according to the invention has general solid-state properties necessary for a compound, stability against heat, light and the like, a suitable optical anisotropy, a suitable dielectric anisotropy, and excellent compatibility with other liquid crysta... | 09/30/2008 |
| 7351737 | 4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity Compounds of the formula where the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with r... | 04/01/2008 |
| 7297715 | PPAR alpha selective compounds for the treatment of dyslipidemia and other lipid disorders A class of chromane and chromene compounds having the structure shown below and pharmaceutically acceptable salts thereof are useful as therapeutic compounds, particularly in the treatment and control of hyperlipidemia, hypercholesterolemia, dyslipidemia, and other ... | 11/20/2007 |
| 7265130 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ... | 09/04/2007 |
| 7259266 | Benzopyran compounds useful for treating inflammatory conditions The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 | 08/21/2007 |
| 7247355 | Liquid crystal compound having chroman ring, liquid crystal composition comprising the compound and liquid crystal display device comprising the composition The present invention relates to a compound having a chroman ring, which has good thermal and optical stability, adequate optical anisotropy, adequate dielectric anisotropy and superior compatibility with other liquid crystal compounds, a liquid crystal composition ... | 07/24/2007 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7122535 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A method of treating pain in a warm-blooded animal comprising administering to anwarm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the di... | 10/17/2006 |
| 7094910 | Bridged diarylpolymethine chromophores An infrared dye, characterised in that the dye comprises two bridged diarylpolymethine type dyes or derivatives thereof connected together at either the 3, 4, 5 or 6 position by a central moiety such that the two dyes are located on each side of the central moiety, ... | 08/22/2006 |
| 7071180 | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2â€... | 07/04/2006 |
| 7038067 | Process for synthesizing d-tocotrienols from 2-vinylchromane compound A process of forming a d-tocotrienol from a (2S)-vinylchromane compound, through hydroboration of the (2S)-vinylchromane to provide an organoborane, followed by coupling the organoborane with a halogenated C-14 sidechain compound under conditions of palladium-cataly... | 05/02/2006 |
| 6919371 | 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions. ... | 07/19/2005 |
| 6869696 | Organic red electro-luminescent device including a heterocyclic emitter The invention concerns an electro-luminescent device in which the luminescent layer contains a compound of general formula I as doping agent or as luminescent compound, whereby the radicals R1 to R12 are identical or are different, and mean hyd... | 03/22/2005 |
| 6867308 | Process for separation of tocopherols A process for separation of specific tocopherols from a mixture of tocopherols is disclosed. The process includes methods of separation of the tocopherols from residues of vegetable oil refining and other various food sources by dissolving in organic solvents and el... | 03/15/2005 |
| 6849658 | Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, —CH2—O—R6, —OR6 or —COR7; R2 is —OR8, —SR8 | 02/01/2005 |
| 6849746 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 02/01/2005 |
| 6818666 | Bi-aromatic compounds linked via a heteroethylene radical, and pharmaceutical and cosmetic compositions using them Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use. ... | 11/16/2004 |
| 6809088 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them The invention relates to new derivatives of 2-(iminomethyl)amino-phenyl which are NO synthase inhibitors and can trap reactive oxygen species. These compounds can notably be used for the treatment of stroke, of neurodegenerative diseases and of ischemic or hemorragi... | 10/26/2004 |
| 6808762 | Oxabicyclooctanes The present invention relates to oxabicyclooctanes of the general formula I. in which R1, R2, A1, A2, A3, A4, L1... | 10/26/2004 |
| 6759401 | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2—, —NH—, (ii) a C1-4-alky... | 07/06/2004 |
| 6727239 | Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity. ... | 04/27/2004 |
| 6716998 | Process for synthesis of 2-yl chroman derivatives This invention provides a process for the stereospecific preparation of 2-yl-chroman and -chromene derivatives of the formula: These compounds are useful for the preparation of optically active 2-aminomethyl- and 2-azahe... | 04/06/2004 |
| 6706724 | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfer... | 03/16/2004 |
| 6706757 | Chroman derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 03/16/2004 |
| 6680390 | Use of substituted vinyl-tetrahydronaphthalenes and vinyl-benzotetrahydropyrans as light protection agents The invention relates to the use of compounds of the formula I ##STR1## in which X is the divalent radical of oxygen, a carbonyl radical, optionally aliphatically substituted imino or the radical .dbd.CR9 R10, Y is a carbonyl grou... | 01/20/2004 |
| 6664411 | Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptab... | 12/16/2003 |
| 6660871 | Synthesis of 4H-chromene derivatives Substituted 4H-chromene derivatives are a new class of compounds that bind to Bcl-2 protein and induce apoptosis in tumor cells. The present invention is directed to an efficient synthetic method for the preparation of these compounds from salicylaldehyde... | 12/09/2003 |
| 6630461 | Derivatives of 2-(iminomethyl) amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A method for treating neurodegenerative diseases in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula ##STR1## wherein A selected from the group consisting of hydrogen and #... | 10/07/2003 |
| 6599903 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them Intermediate compounds having the formula ##STR1## wherein the substituents are defined as set forth in the disclosure.... | 07/29/2003 |
| 6566397 | Acyclic isoprenoid ether derivatives as chemotherapeutics A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-l... | 05/20/2003 |
| 6455578 | Aromatic derivatives and iron complexes thereof for the use as normalizing agents of the iron level The present invention is directed to aromatic derivatives of formula (I), wherein: R1 is (a), wherein R3 and R4 are selected from between H and OH, provided that R3 and R4 are not simultaneously H, an... | 09/24/2002 |
| 6448269 | Glycoprotein IIb/IIIa antagonists This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and aci... | 09/10/2002 |
| 6420334 | Tetracyclic acetals 2-Alkoxydecahydro-2,3a,4,4,7-pentamethyl-3,7a-methano-7aH-indeno[5,6-b]fura ns are valuable novel woody fragrances for the preparation of perfume oils.... | 07/16/2002 |
| 6399653 | Ring fused dihydropyrans, process for preparation and use thereof The invention relates to compounds of the formula I ##STR1## in which the radicals R1, R2, R3 and A have the meaning mentioned in the description. The invention further relates to a process for the preparation of the compo... | 06/04/2002 |
| 6353014 | 15-ketal postaglandins for the treatment of glaucoma or ocular hypertension A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: ##STR1##... | 03/05/2002 |
| 6344558 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I ##STR1## a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.... | 02/05/2002 |
| 6340700 | 2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same A compound of the formula ##STR1## wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.... | 01/22/2002 |
