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| Number | Title | Issue Date |
| RE40572 | Fluorescent probe for the quantitation of zinc A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and... | 11/11/2008 |
| 7317038 | Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regene... | 01/08/2008 |
| 7244760 | Methods for preparation and use of psorospermin analogs Psorospermin is a cytotoxic dihydroflranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method... | 07/17/2007 |
| 7244761 | Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regene... | 07/17/2007 |
| 7105685 | Cannabinol derivatives The invention provides cannabinol derivatives and pharmaceutical preparations thereof. ... | 09/12/2006 |
| 7041821 | Synthetic molecules for labeling histidine-rich proteins The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn2+ ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni... | 05/09/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6939977 | Analgesic and immunomodulatory cannabinoids Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. ... | 09/06/2005 |
| 6933384 | Synthetic molecules for labeling histidine-rich proteins The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn2+ ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni... | 08/23/2005 |
| 6903226 | Fluorescent probe for the quantitation of zinc A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and... | 06/07/2005 |
| 6809176 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 10/26/2004 |
| 6770671 | 7,8-dihydro-xanthenone-8-carboxylic acid derivative and novel microbe producing the same Disclosed are a novel compound represented by the following chemical formula (1), useful for the prophylaxis and treatment of angiogenic diseases, its production, and a novel microorganism producing the same. Aspergillus sp. Y80118 isolated from soil was found to pr... | 08/03/2004 |
| 6613797 | Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins Therapeutic compounds and compositions for the treatment of infectious diseases are disclosed. The compounds are xanthones and xanthone derivatives, such as 3,5-bis-&3xb5;-(N,N-diethylamino)amyloxyxanthone. The described compositions include such compound... | 09/02/2003 |
| 6525088 | Agent for measurement of singlet oxygen Compounds represented by the following general formula (I): ##STR1## wherein R1, R2, R3, R4, R5, and R6 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl grou... | 02/25/2003 |
| 6472228 | Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples This invention relates to novel tracers and their synthesis and use in an immunoassay for the detection of controlled drugs such as amphetamine (APM), methamphetamine (MAPM) and their derivatives, in a biological or aqueous sample. In particular, this inv... | 10/29/2002 |
| 6458974 | Synthesis of ଲ-lapachone and its intermediates A novel process for synthesizing ଲ-lapachone (beta-lapachone), an agent that has demonstrated significant antineoplastic activity against human cancer lines. The process comprises the conversion of starting material, 2-hydroxy-1,4-naphothoquinone in... | 10/01/2002 |
| 6420131 | Use of fluorescein aryl ethers in high throughput cytochrome P450 inhibition assays Novel fluorescent substrates of human cytochrome P450 enzymes are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing cytochrome P450 enzyme activity and in selecting compounds which inhibit cytochro... | 07/16/2002 |
| 6229024 | Method for detecting neuronal degeneration and anionic fluorescein homologue stains therefor An anionic fluorescein homologue capable of selectively staining degenerating neurons in brain slices, the method of making the anionic fluorescein homologue, and the method of using the same for detecting neuronal degeneration. Two anionic fluorescein ba... | 05/08/2001 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 5763625 | Synthesis and use of ଲ-lapachone analogs 3-Substituted-ଲ-lapachone analogs and their use either alone or to augment chemotherapy or radiotherapy to induce programmed neoplastic cell death without exhibiting toxicity to surrounding normal cells are disclosed. In particular, 3-allyl-ଲ-... | 06/09/1998 |
| 5635530 | (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them The invention relates to novel compounds of formula (I) wherein R is a hydrogen atom or a C1 -C5 alkyl group and R2 is selected from the group consisting of: (a) a straight-chained or branched C5 -C12... | 06/03/1997 |
| 5623080 | Fluorone and pyronin Y derivatives A compound of the formula (I) or (II): ##STR1## where R1, R2, R5 and R6 are the same or different and represent a hydrogen atom or a halogen atom and R1 and R2 may combine to form a ri... | 04/22/1997 |
| 5338753 | (3R,4R)-Ɗ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics Non-psychoactive derivatives of Ɗ6 -THC-7-oic acid are described which have analgesic and anti-inflammatory properties.... | 08/16/1994 |
| 5310909 | Photochromic compounds, a process for their preparation, and their use Compounds of the formula I ##STR1## in which X is O, S, SO, SO2 or NR13, R13 is, for example, methyl, and R1 to R12, independently of one another, are, for example, H, C1 -C12 | 05/10/1994 |
| 5302703 | Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels The present invention is directed to novel THC derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the THC metabolites. The resulting novel antigens may be ... | 04/12/1994 |
| 5276053 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 01/04/1994 |
| 5254595 | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group, in optically active or inactive form as well as their ... | 10/19/1993 |
| 5229123 | Antifungal agents The compound of the formula ##STR1## and its tautomer are obtained from cultures of Eupenicillium sp. The compound has antifungal activity.... | 07/20/1993 |
| 5202446 | Fluoridated monomers based on 9-phenyl-9-perfluoroalkylxanthene Disclosed are rigid fluorinated monomers 9-phenyl-9-perfluoroalkylxanthene ##STR1## . The monomers have utility in the preparation of advanced high-performance polymers, particularly polyimides.... | 04/13/1993 |
| 5200116 | Photochromic chromene compounds Described are a series of novel photochromic benzopyran and naphthopyran compounds substituted with (1) a cyclopropyl group and (2) a phenyl, substituted phenyl, or 5-member aromatic heterocyclic group at the 2-position of the benzopyran or naphthopyran r... | 04/06/1993 |
| 5176854 | Non-linear optical device According to the present invention, there is provided a non-linear optical device comprising a non-linear optical medium comprising an organic compound, which remarkably improves the non-linear optical properties. The non-linear optical device according t... | 01/05/1993 |
| 5144030 | Fluorescene polarization immunoassay for tetrahydrocannabinoids This disclosure related to a method and reagents for determining tetrahydrocannabinoids (THC) and THC metabolites in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determin... | 09/01/1992 |
| 4876276 | (3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols The invention relates to novel (3S,4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinol homologes and derivatives, essentially free of the (3R,4R) form and to pharmaceutical compositions which have a potent analgetic, antiemetic and antiglaucoma effect, whi... | 10/24/1989 |
| 4599327 | Dibenzo[bd]pyran derivatives, process for the preparation thereof and pharmaceutical compositions containing same 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R2' stands for C1 to C12 alkyl or a group of the formula ##STR2## in which R11 is C1 to C | 07/08/1986 |
| 4503066 | Spiro-linked pyrrolidine-2,5-diones active as enzyme aldose reductase inhibitors The invention provides various medical compositions for use in treating or preventing certain of the side effects of diabetes or galactosemia. The active ingredients are selected from a series of novel aldose reductase inhibitory spiro-linked pyrrolidine-... | 03/05/1985 |
| 4496557 | Tricyclic ethers, their preparation and the pharmaceutical compositions containing them Compounds corresponding to the general formula: ##STR1## in which X and Y identical or different, represent a hydrogen or a halogen atom, a lower alkyl, a lower alkoxy or a trifluormethyl group, A represents a methylene group, a direct bond or an imino--N... | 01/29/1985 |
| 4463001 | 6-Substituted 6H-dibenzo[b,d]pyran derivatives and process for their preparation The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.... | 07/31/1984 |
| 4454144 | Substituted dibenzo[b,d]pyran analgesics The present invention comprises novel compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof wherein: G is hydroxymethylene or carbonyl; Ra and Rb are each methyl or hydrogen; R1 is hydrogen or alkanoy... | 06/12/1984 |
| 4395560 | Preparation of 6a,10a-trans-hexahydrodibenzopyranones Reaction of an O-methyl or O-ethyl resorcinol with a cyclohexene carbinol derivative in the presence of a catalyst affords a 6a,10a-trans-1-methoxy or 1-ethoxy-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-one derivative.... | 07/26/1983 |
| 4278603 | Novel polymorphic crystalline form of dibenzopyranone Stable polymorphic crystalline form of trans-dl-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,-10,10a- hexahydro-9H-dibenzo[b,d]pyran-9-one, capable of producing significant blood levels in mammals for long periods of time after oral administrat... | 07/14/1981 |
