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| Number | Title | Issue Date |
| 7674922 | Process for production of delta-9-tetrahydrocannabinol The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the d... | 03/09/2010 |
| 7449589 | Process for purifying (-)-Δ-trans-tetrahydrocannabinol A process for separating (−)-Δ9-trans-tetrahydrocannabinol from a mixture of cannabinoids is disclosed. The process comprises at least one chromatographic step wherein a mobile phase passes trough a stationary phase. The stationary phase comprises a de... | 11/11/2008 |
| 7402686 | Cannabinoid crystalline derivatives and process of cannabinoid purification Δ9 tetrahydrocannabinol (THC) esters comprising the reaction product of THC with at least one aryl sulfonyl chloride in the presence of at least one tertiary amine. The resulting aryl sulfonic THC esters are highly crystalline and stable at room temperature in air,... | 07/22/2008 |
| 7399872 | Conversion of CBD to Δ-THC and Δ-THC Methods of converting cannabidiol to Δ8-tetrahydrocannabinol or Δ9-tetrahydrocannabinol are described. The described methods produce higher yields and higher purity compared to prior art methods. ... | 07/15/2008 |
| 7361691 | Method of treating cancers using β-lapachone or analogs or derivatives thereof Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic kinase modulator, preferably imatinib. This combination of the cell cyc... | 04/22/2008 |
| 7326447 | Benzochromene derivatives The present invention relates to benzochromene derivatives of the formula I in which the various parameters are as defined in the text, and to liquid-crystal media which comprise these compounds, and to the use o... | 02/05/2008 |
| 7323576 | Synthetic route to dronabinol Dronabinol, the tetrahydrocannabinol compound which comprises the active constituent of marijuana and is pharmaceutically useful as an antiemetic, is prepared by a process involving reaction of cis-menth-1-enc-3,8-diol with olivetol to form 1,3-dihydroxy-2-[(1R,6R)-... | 01/29/2008 |
| 7321047 | Separation of tetrahydrocannabinols An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I: R—(CH2)n—N═C═X (I) | 01/22/2008 |
| 7279499 | Substituted benzopyrans as selective estrogen receptor-beta agonists The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the present invention are useful as Estrogen Receptor ? agonists. Such ago... | 10/09/2007 |
| 7279500 | Sulfonamide cannabinoid agonists and antagonists Cannabinoid agonists and antagonists are provided for use in the treatment of disorders such as acute and chronic pain, inflammation, loss of appetite, convulsions, multiple sclerosis, nausea and vomiting. The cannabinoid agonists and antagonists contain a sulfonami... | 10/09/2007 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7235584 | Non-psychotropic cannabinoids Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) ... | 06/26/2007 |
| 7217734 | Substituted benzopyrans as selective estrogen receptor-beta agonists The present invention relates to substituted benzopyran derivatives, stereoisomers, and pharmaceutical acceptable salts thereof and processes for the preparation of the same. The compounds of the present invention are useful as Estrogen Receptor β agonists. Such ag... | 05/15/2007 |
| 7195882 | Monoclonal antibodies specific for buprenorphine and metabolites thereof The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that s... | 03/27/2007 |
| 7169942 | Cannabinoid derivatives, methods of making, and use thereof 1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having ac... | 01/30/2007 |
| 7105685 | Cannabinol derivatives The invention provides cannabinol derivatives and pharmaceutical preparations thereof. ... | 09/12/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6939977 | Analgesic and immunomodulatory cannabinoids Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. ... | 09/06/2005 |
| 6803381 | Carbamic acid derivatives The present invention relates to compounds of formula wherein R1 is hydrogen or lower alkyl; R2, R2′ are each independently hydroge... | 10/12/2004 |
| 6610737 | Non-psychotropic cannabinoids Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereosp... | 08/26/2003 |
| 6608216 | Process for the preparation of chiral glucocorticoid receptor agents The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.... | 08/19/2003 |
| 6593480 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 07/15/2003 |
| 6576595 | Xanthone derivatives, processes for their preparation and their use for controlling harmful fungi, and compositions comprising these derivatives Xanthone derivatives of the formula I ##STR1## where the index and the variables are as defined below: n is 0, 1 or 2; R1 is alkyl or haloalkyl; R2,R3 are alkoxy, alkenyloxy or alkynyloxy, or R2 and R3 tog... | 06/10/2003 |
| 6458974 | Synthesis of ଲ-lapachone and its intermediates A novel process for synthesizing ଲ-lapachone (beta-lapachone), an agent that has demonstrated significant antineoplastic activity against human cancer lines. The process comprises the conversion of starting material, 2-hydroxy-1,4-naphothoquinone in... | 10/01/2002 |
| 6448405 | Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 09/10/2002 |
| 6403521 | Catalyst comprising nitrogen-containing heterocyclic compound, and process for producing organic compound using the catalyst A catalyst is for use in a reaction using an oxygen-atom-containing reactant and includes a nitrogen-containing heterocyclic compound of the following formula (1): ##STR1## wherein each of R1 and R2 is, identical to or different from... | 06/11/2002 |
| 6353018 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/05/2002 |
| 6329534 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 12/11/2001 |
| 6245807 | Treatment of human prostate disease We have now discovered that unexpectedly compounds of the following formulae I or 11 can be used to selectively stimulate the death of mammalian prostate cells, including both epithelial cell and prostate cancer cells, and thus are useful in treating pros... | 06/12/2001 |
| 6008383 | Method of preparing delta-9-tetrahydrocannabinol esters The present invention provides an economical and efficient process for converting delta-9-tetrahydrocannabinol to a variety of ester analogs. Delta-9-tetrahydrocannabinol is esterified by reaction with a carboxylic acid, an acid halide or an acid anhydrid... | 12/28/1999 |
| 5998613 | 4-aminotetrahydrobenzisoxazole or -isothiazole compounds The present invention relates to novel 4-aminotetrahydrobenzisoxazoles or 4-aminotetrahydrobenziothiazoles having gamma-aminobutanoic acid (GABA)-uptake inhibiting activity and thus useful in the treatment of analgesia, psychosis, convulsions, anxiety, ep... | 12/07/1999 |
| 5977077 | Xanthone analogs for the treatment of infectious diseases Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also disclosed are methods for the treatment of infectious diseases us... | 11/02/1999 |
| 5888432 | 2-Adamantyl benzopyrans the compositions and (co)polymer matrices containing them The present invention has for subjects, novel benzopyran derivatives, substituted in position 2 with an adamantyl group as well as the compositions and (co)polymer matrices containing such derivatives. Said derivatives possess interesting photochromic pro... | 03/30/1999 |
| 5872148 | Compositions useful as a cannabinoid receptor probe A composition of matter, comprising a cannabinol compound having the structure ##STR1## wherein, Q is --C(R1)(Y1)--(CH2)n --Z1 ; R1 is --H or --CH3 ; Y1 is --CH | 02/16/1999 |
| 5792389 | Water soluble laser dyes Novel water soluble dyes of the formula I are provided ##STR1## wherein R1 and R4 are alkyl of 1 to 4 carbon atoms or hydrogen; or R1 -R2 or R2 -R4 form part of aliphatic heterocyclic ... | 08/11/1998 |
| 5763625 | Synthesis and use of ଲ-lapachone analogs 3-Substituted-ଲ-lapachone analogs and their use either alone or to augment chemotherapy or radiotherapy to induce programmed neoplastic cell death without exhibiting toxicity to surrounding normal cells are disclosed. In particular, 3-allyl-ଲ-... | 06/09/1998 |
| 5717109 | Excitatory amino acid receptor antagonists The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as anta... | 02/10/1998 |
| 5635530 | (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them The invention relates to novel compounds of formula (I) wherein R is a hydrogen atom or a C1 -C5 alkyl group and R2 is selected from the group consisting of: (a) a straight-chained or branched C5 -C12... | 06/03/1997 |
| 5633357 | Synthesis of carboxylic acid glucuronides A method of producing a carboxylic acid glucuronide by reacting a carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-Ɗ8 - or Ɗ9 -THC carboxylic acid glucuronide havi... | 05/27/1997 |
| 5616788 | N -2-(4-Nitrophenylsulfonyl) ethoxycarbonyl-amino acids Protected amino acid derivatives of the general formula ##STR1## wherein R1 represents hydrogen atom, and R2 represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, tert-butoxymethyl, 1-tert-butoxyethyl, 2-methyl... | 04/01/1997 |
