Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7547792 | Process for purifying thioctic acid in water Process for purifying thioctic acid in water comprising the following steps: a) dissolving the thioctic acid in an aqueous alkaline solution or alternatively dissolving a thioctic acid salt, if necessary adjusting the pH to alkaline values, b) acidifying the solutio... | 06/16/2009 |
| 7429614 | Medicament containing an effector of the glutathione metabolism together with α-lipoic acid for treating diabetes mellitus The invention relates to a medicament containing an effector of the glutathione metabolism together with α-lipoic acid for treating diabetes mellitus. This medicament enables disturbances of the thiol-disulfide status or those that occur, for example, in diabetes m... | 09/30/2008 |
| RE40480 | 1,3-Propane diol esters and ethers and methods for their use in drug delivery The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 ... | 09/02/2008 |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7285664 | Heterocyclic or benzenic derivatives of lipoic acid, their preparation and their use as medicaments A compound having a formula selected from the group consisting of wherein the substituents are defined as in the specification. The compounds are useful as intermediates in the preparation of compounds of formula... | 10/23/2007 |
| 7235582 | Basic salt of thioctic acid with L-carnitine Salt of thioctic acid with L-carnitine with the formula: AY(X)x where A is where Y is the cation of an alkaline metal, of an alkaline earth metal or is a quaternary ammonium group,... | 06/26/2007 |
| 7232915 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe... | 06/19/2007 |
| 7220760 | Quinoline derivatives as CRTH2 antagonists The invetion relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the description... | 05/22/2007 |
| 7208609 | Method for producing thioctic acid The invention relates to a method for producing pure racemic, R- or S-thioctic acid or mixtures thereof by reacting 6,8-disubstituted octanoic acid or their salts or esters with sulfides, sulfur or sulfites. ... | 04/24/2007 |
| 7202270 | Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses A process for the manufacture of new crystalline salts of N-[2-(dimethylamino)ethyl]-1,2-dithiolane-3-pentanamide (racemic and chiral forms) is described. Such salts are stable, crystalline and have very good solubility in water. The salts exhibit antioxidant proper... | 04/10/2007 |
| 7169324 | Gelling agent and production method thereof, liquid crystal composition and charge transfer complex Disclosed herein are a gelling agent composed of a functional amino acid compound having a tetrathiafulvalenyl group, and a production method of a gelling agent, comprising reacting a tetrathiafulvalene derivative with an amino acid derivative in the presence of 1-e... | 01/30/2007 |
| 7169942 | Cannabinoid derivatives, methods of making, and use thereof 1′-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having ac... | 01/30/2007 |
| 7109362 | Process for the preparation of lipoic acid and dihydrolipoic acid The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO | 09/19/2006 |
| 7038062 | Synthesis of cyclic trithiocarbonates from epoxides This invention provides a low cost technique for synthesizing cyclic trithiocarbonates by a simple one step process from epoxides that can be conducted under atmospheric pressure. This synthesis can be depicted as follows: | 05/02/2006 |
| 7030251 | Modifications of the trometamol salt of R-thioctic acid as well as a process for their production The invention relates to new modifications of the trometamol salt of R-thioctic acid of the formula I, processes for their production, pharmaceutical preparations containing these modifications, and their medical applic... | 04/18/2006 |
| 7030154 | Stability of lipoic acid A method of stabilizing R-α-lipoic acid includes combining R-α-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress includes R-α-lipoic acid and nicotinamide in a weight ratio of between abo... | 04/18/2006 |
| 6951887 | Lipoic acid derivatives and their use in treatment of disease This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenas... | 10/04/2005 |
| 6900338 | Scavenger compounds The present invention provides novel compounds having scavenging and anti-ROS properties and pharmaceutical composition comprising these compounds for treatment of conditions associated with oxidative stress or free radical injury. The compounds of the invention are... | 05/31/2005 |
| 6864374 | Synthesis of r(+)α-lipoic acid Process for the synthesis of R(+)α-lipoic acid comprising the following stages: a) Salifying of racemic 6,8-halo-octanoic acid with S(−)α-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)6,8-di-halo-octanoic acid-S... | 03/08/2005 |
| 6844449 | Modifications of the trometamol salt of R-thioctic acid as well as a process for their production The invention relates to new modifications of the trometamol salt of R-thioctic acid of the formula I, processes for their production, pharmaceutical preparations containing these modifications, and their medical appli... | 01/18/2005 |
| 6844450 | Process for the production of a racemic thioctic acid Process for the synthesis of racemic thioctic acid comprising the following stages: a) reaction of the alkyl ester of 6,8-di-halo-octanoic acid in an organic solvent with an aqueous solution of alkali disulfide in presence of a compound for phase transfer catalysis ... | 01/18/2005 |
| 6835844 | Acrylic esters and use thereof The present invention provides an acrylic ester compound represented by formula (1), a polymerizable composition containing the acrylic ester compound, and a cured product and an optical component obtained by polymerizing the polymerizable composition: ... | 12/28/2004 |
| 6794471 | Acrylic ester compound usage thereof An acrylic ester compound represented by the general formula (1): wherein, R1 and R2 represent independently a hydrogen atom, an alkyl group which may have a substituent, an aromatic alkyl group whi... | 09/21/2004 |
| 6787062 | Producing liquid crystals with CF2O bond The invention relates to a process for the preparation of compounds having at least one —CF2O— bridge in the molecule, which comprises initially reacting a bis(alkylthio)carbenium salt with a compound containing at least one hydroxyl group in the pres... | 09/07/2004 |
| 6686458 | Synthetic molecules that specifically react with target sequences The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenic... | 02/03/2004 |
| 6670484 | Process for the production of r(+)-lipoic acid Process for the synthesis of R(+)-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)-lipoic ... | 12/30/2003 |
| 6649639 | Antipicornaviral compounds, compositions containing them, and methods for their use Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treatin... | 11/18/2003 |
| 6620964 | Preparation of dihydroxycarboxylic esters in the absence of solvents A description is given of a process for preparing dihydroxycarboxylic esters and of an overall process for preparing R-(+)--lipoic acid.... | 09/16/2003 |
| 6570025 | Sulfur compound and use thereof This invention provides sulfur-containing (meth)acrylic ester compounds each of which is represented by the following formula (1); ##STR1## wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group or may be fu... | 05/27/2003 |
| 6492405 | Nitric oxide donors and pharmaceutical compositions containing them The present invention provides a compound containing at least one sulfhydryl group and at least one NO donor group, wherein said compound is a) a compound containing one or more sulfhydryl groups linked to at least one aromatic ring or a heteroaromatic ri... | 12/10/2002 |
| 6462202 | Method for the production of a solvent-free -liponic acid Solvent-free -lipoic acid is produced by dissolving a) the -lipoic acid to be purified in aqueous alkaline solution, or dissolving the salt thereof in water and adjusting an alkaline pH, b) removing solid impurities present where appropriate from the ... | 10/08/2002 |
| 6458908 | Sulfur-containing unsaturated carboxylate compound and its cured products A sulfur-containing unsaturated carboxylate compound comprising a sulfur-containing substituent and at least two ,ଲ-unsaturated carboxylic acid residues, which are each attached to a secondary or tertiary carbon atom via an oxygen atom; a pol... | 10/01/2002 |
| 6441024 | Crystal modification of lipoic acid In the 2 .THETA. diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 .THETA.=23°.... | 08/27/2002 |
| 6387945 | Lipoic acid analogs A compound is provided having the formula I: ##STR1## wherein the variables are defined in the specification. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species ar... | 05/14/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6369098 | Dithiolane derivatives The present invention describes methods for synthesizing novel dithiolane derivatives, ligands with high affinity for the nuclear hormone receptors, peroxisome proliferator-activated receptor-γ (PPARγ) and/or PPAR. Methods for using these compoun... | 04/09/2002 |
| 6353011 | 1,2-dithiolane derivatives This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of cardiovascular diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (maligna... | 03/05/2002 |
| 6342517 | Potassium channel activators and their use Novel thienopyran compounds are disclosed, useful as anti-hypertensive agents and for asthma treatment. One group of the compounds has a heterocyclic ring spiro-connected at the 7-position of the thienopyran ring structure. Use of thienopyran compounds in... | 01/29/2002 |
| 6331559 | Lipoic acid derivatives and their use in treatment of disease This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate d... | 12/18/2001 |
| 6331554 | Antipicornaviral compounds, compositions containing them, and methods for their use Picornaviral 3C protease inhibitors of formula I, obtainable by chemical synthesis, that inhibit or block the biological activity of the picornaviral 3C protease are described. ##STR1## These compounds, as well as pharmaceutical compositions that contain ... | 12/18/2001 |
