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| Number | Title | Issue Date |
| 7368072 | Photochromic contact lenses and methods of manufacturing Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a ca... | 05/06/2008 |
| 7361691 | Method of treating cancers using β-lapachone or analogs or derivatives thereof Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic kinase modulator, preferably imatinib. This combination of the cell cyc... | 04/22/2008 |
| 7329687 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) | 02/12/2008 |
| 7320826 | Photochromic articles with reduced temperature dependency and methods for preparation Described are photochromic articles that include a substrate, a temperature dependent reducing amount of at least one organic photochromic material (b) that changes from more absorbing to less absorbing of radiation in its activating spectral absorbance as the tempe... | 01/22/2008 |
| 7261843 | Photochromic optical article Describes a photochromic article, e.g., an ophthalmic photochromic plastic article, such as a lens, in which the article includes (1) a rigid substrate, e.g., a transparent substrate such as a glass or organic polymeric substrate, as for example, a thermoset or ther... | 08/28/2007 |
| 7262295 | Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles Described are photochromic materials of indeno [2′,3′:3,4]naphtho[1,2-b]pyran structure, characterized in that they have a nitrogen or sulfur containing substituent at the 11-position ring atom, are substantially free of spiro-substituents at the 13-position and... | 08/28/2007 |
| 7253207 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 08/07/2007 |
| 7250120 | Benzo-, naphtho- and phenanthrochromene substituted by carbamated or ureated phenyls, preparation thereof and compositions and articles containing them Disclosed are novel benzo-, naphtho- and phenanthrochromenes substituted by carbamated or ureated phenyls having the following general formula (I): wherein R1 represents a group | 07/31/2007 |
| 7214754 | Polymerizable polyol (allyl carbonate) compositions A polymerizable composition is described, which composition comprises a major amount of a polyol(allyl carbonate) monomer, e.g., diethylene glycol bis(allyl carbonate) monomer, and a minor amount of a radically polymerizable second monomer represented by the general... | 05/08/2007 |
| 7179848 | Method for coloring a transparent article made of polycarbonate and resulting article The invention concerns a method which consists in irradiating at least one face of the article with UV radiation, causing the article to be photodegraded over a thickness of at least 1 μm, and in contacting the irradiated face of the article with a colouring agent ... | 02/20/2007 |
| 7166357 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation Described are photochromic articles that include a substrate and a photochromic amount of at least one organic photochromic material (b) represented by graphic formula XIII adapted to change from an unactivated state to an activated state by exposure to radiation su... | 01/23/2007 |
| 7147889 | Organic photochromic compositions of improved kinetic performance Described are imbibition compositions that incorporate kinetic enhancing additive(s) into photochromic polymeric host material. Kinetic enhancing additives include organic polyol(s), epoxy-containing compound(s) or a mixture thereof that improves the performance of ... | 12/12/2006 |
| 7144969 | Impact resistant polyureaurethane and polyureaurethane prepolymer having low NCO/OH ratio The present invention relates to a polyureaurethane wherein the prepolymer comprising said polyureaurethane has a NCO to OH equivalent ratio of from 2.0 to less than 2.5. In an embodiment, the polyureaurethane prepolymer comprises a polyisocyanate and at least one O... | 12/05/2006 |
| 7105685 | Cannabinol derivatives The invention provides cannabinol derivatives and pharmaceutical preparations thereof. ... | 09/12/2006 |
| 7098290 | Method of preparing an optical polymerizate The present invention is directed to a novel method of preparing a polymerizate, which includes the step of polymerizing a two-component composition, which includes: a first component containing at least one polycyanate reactant having at least two functional groups... | 08/29/2006 |
| 7094368 | Pyrano-quinolines, pyrano-quinolinones, combinations thereof, photochromic compositions and articles Described are compositions of at least one material represented by a pyrano[3,2-c]quinoline structure, a pyrano[3,2-c]quinolinone structure or mixtures thereof. The pyrano[3,2-c]quinoline structure is characterized by having a nitrogen atom at the 6-position ring at... | 08/22/2006 |
| 7087698 | Method of preparing an optical polymerizate The present invention is directed to a novel method of preparing a polymerizate, which includes the step of polymerizing a two-component composition, which includes: a first component containing at least one polycyanate reactant having at least two functional groups... | 08/08/2006 |
| 7051290 | Graphical interface for receiving eyeglass prescription information A high volume lens curing system is described. The high volume lens curing system is configured to cure multiple eyeglass lenses in a continuous manner. The lens curing system includes a computer-implemented method configured to collect prescription information, sav... | 05/23/2006 |
| 7008568 | Photochromic naphthopyran compounds: compositions and articles containing those naphthopyran compounds A photochromic naphthopyran displays good color distribution when the naphthopyran has a central nucleus of the formula: wherein F is a 5-member, 6-member, or 7-member heterocyclic ring group ha... | 03/07/2006 |
| 6967249 | Photochromic 3H-naphtho[2,1-b]-pyran compounds and photochromic articles produced therewith Specific photochromic 3H-naphtho[2,1-b]-pyran compounds useful with various types of synthetic resin materials to form photochromic articles, especially ophthalmic lenses, and photochromic articles formed with such compounds. The compounds of the invention have espe... | 11/22/2005 |
| 6960300 | Process for preparing water soluble diterpenes and their applications Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Fo... | 11/01/2005 |
| 6939007 | Photochromic bis-naphthopyran compounds and methods for their manufacture The invention provides photochromic bis-naphthopyran compounds as well as methods for their manufacture and their use. The bis-naphthopyran compounds of the invention exhibit a wide range of color, i.e., from pink to purple to blue gray, upon activation by a source ... | 09/06/2005 |
| 6911055 | Method for coloring a transparent article made of polycarbonate and resulting article The invention concerns a method which comprises irradiating at least one face of an article with UV radiation, causing the article to be photodegraded over a thickness of at least 1 μm and contacting the irradiated face of the article with a coloring agent, so as t... | 06/28/2005 |
| 6890950 | Lapachone delivery systems, compositions and uses related thereto In part, the present invention is directed to a system comprising a lapachone or a prodrug thereof and a polymer, such as a biocompatible and optionally biodegradable polymer, methods for treatment using the subject polymer compositions, and methods of making and us... | 05/10/2005 |
| 6887533 | Fluorinated oxaanthracenes and their use in liquid-crystal mixtures Compounds of the formula (I) where: X1 is H or F G1-G2 is —CH2—CH— or CH═C— R1, R | 05/03/2005 |
| 6863843 | Naphthopyran compounds, photoresponsive compositions and lenses A photochromic [1,2-b] naphthopyran having a fluoro substituent in at least one of the 7-position or the 9-position of the naphthopyran provides a stable photochromic compound with a narrow range of absorption. A preferred photochromic naphthopyran has the 2-positio... | 03/08/2005 |
| 6809176 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 10/26/2004 |
| 6747145 | Photochromic bis-naphthopyran compounds and methods for their manufacture The invention provides photochromic bis-naphthopyran compounds as well as methods for their manufacture and their use. The bis-naphthopyran compounds of the invention exhibit a wide range of color, i.e., from pink to purple to blue gray, upon activation by a source ... | 06/08/2004 |
| 6719926 | Chromene compound A chromene compound which develops yellow to red color, a high color density and a little initial color and which, when used in combination with an existing photochromic compound that exhibits blue color so as to develop a neutral tint, maintains uniformity in the c... | 04/13/2004 |
| 6700001 | Process for stereoselective synthesis of 2-hydroxymethyl chromans A process for the stereoselective synthesis of 2-hydroxymethyl-chromans of formula (II) is provided ##STR1## where R, R1, R2 and R3 are as defined herein. The compound of formula (II) is prepared using an optically active ... | 03/02/2004 |
| 6630597 | Photochromic 6-aryl substituted 3H-naphtho(2,1-b)pyrans Described are novel photochromic 6-aryl substituted 3H-naphtho[2,1-b]pyran compounds, examples of which are naphthopyran compounds having a substituted aryl group at the number 6 carbon atom and certain substituents at the 3-position of the pyran ring. Ce... | 10/07/2003 |
| 6627121 | Photochromic naphthopyran compounds A photochromic naphthopyran of formula (I) wherein R1 through R15, which may be the same or different, are independently selected from the group consisting of hydrogen, C1 -C4 alkyl, C1 -C4... | 09/30/2003 |
| 6602903 | Substituted heterocyclic compounds The invention relates to compounds of formula (I): ##STR1## and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.... | 08/05/2003 |
| 6555028 | Polymeric matrix compatibilized naphthopyrans Described are polymeric matrix compatibilized naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one substituent containing terminal and/or pend... | 04/29/2003 |
| 6525194 | Chromene compound A chromene compound which develops yellow to red color, a high color density and a little initial color and which, when used in combination with an existing photochromic compound that exhibits blue color so as to develop a neutral tint, maintains uniformi... | 02/25/2003 |
| 6478989 | Aromatic substituted naphthopyrans Described are photochromic 2H-naphtho[1,2-b]pyrans characterized by having an aromatic substituent in the 5 position. The aromatic group at 5-position of the naphthopyran is a substituted or unsubstituted aryl group or other substituted or unsubstituted a... | 11/12/2002 |
| 6478988 | Photochromic substituted naphthopyran compounds The present invention relates to naphthopyrans, particularly 3,3-[substituted]-naphtho[2,1-b]pyrans and 2,2-[substituted]-naphtho[1,2-b]pyrans and particularly to novel substitution on the 3-position and 2-position, respectively, of these naphthopyra... | 11/12/2002 |
| 6458974 | Synthesis of ଲ-lapachone and its intermediates A novel process for synthesizing ଲ-lapachone (beta-lapachone), an agent that has demonstrated significant antineoplastic activity against human cancer lines. The process comprises the conversion of starting material, 2-hydroxy-1,4-naphothoquinone in... | 10/01/2002 |
| 6403347 | HIV integrase inhibitors Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts... | 06/11/2002 |
| 6398987 | Naphthopyrans having a perfluoroalkyl substituent in position 5, preparation and compositions and matrices containing them The present invention relates to novel compounds of the naphthopyran type which have a perfluoroalkyl group (X) in position 5. These compounds are of formula (I) given below: ##STR1## These compounds (I) possess interesting photochromic properties. The ... | 06/04/2002 |
