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| Number | Title | Issue Date |
| 8084627 | Hydroxymethyl fluorescein derivatives for use as biological markers and dyes Hydroxymethyl fluorescein derivatives are provided. The derivatives can be easily conjugated to other molecules, and are more permeable than other fluorescein derivatives. Methods of making the derivatives are also provided. ... | 12/27/2011 |
| 7592468 | Production of Δ 9 tetrahydrocannabinol Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is then converted to Δ9 TH... | 09/22/2009 |
| 7419848 | Compound having anchoring group, electronic device comprising the compound, and methods of producing them Provided are compounds having a thiol group as an anchoring group introduced into a Rose Bengal molecule, a method of producing the compound, an electronic device comprising the compound immobilized on an electrode by a self-assembling method, and a method of manufa... | 09/02/2008 |
| 7361774 | Chalcone compound The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to fo... | 04/22/2008 |
| 7358377 | Schweinfurthin analogues Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods c... | 04/15/2008 |
| 7344701 | Xanthene dyes The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and usi... | 03/18/2008 |
| 7326447 | Benzochromene derivatives The present invention relates to benzochromene derivatives of the formula I in which the various parameters are as defined in the text, and to liquid-crystal media which comprise these compounds, and to the use o... | 02/05/2008 |
| 7282575 | Functional peptide nucleic acid monomer and process for producing the same A compound represented by the general formula (I) below: In the formula, A is as defined in the specification and B denotes where n is an integer of 1 to 4, ... | 10/16/2007 |
| 7235662 | Modulators of the glucocorticoid receptor and method Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the s... | 06/26/2007 |
| 7186850 | Synthesis of cannabinoids The present invention relates to a process for the production of compound (A) comprising reacting compound (B) with compound (C). A further ring closure reaction may be necessary. The invention further relates to certain novel compounds of formula (B). ... | 03/06/2007 |
| 7105685 | Cannabinol derivatives The invention provides cannabinol derivatives and pharmaceutical preparations thereof. ... | 09/12/2006 |
| 7094910 | Bridged diarylpolymethine chromophores An infrared dye, characterised in that the dye comprises two bridged diarylpolymethine type dyes or derivatives thereof connected together at either the 3, 4, 5 or 6 position by a central moiety such that the two dyes are located on each side of the central moiety, ... | 08/22/2006 |
| 7087765 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 08/08/2006 |
| 6939977 | Analgesic and immunomodulatory cannabinoids Disclosed are novel compounds represented by the following structural formula: R-X-Y; and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. ... | 09/06/2005 |
| 6887533 | Fluorinated oxaanthracenes and their use in liquid-crystal mixtures Compounds of the formula (I) where: X1 is H or F G1-G2 is —CH2—CH— or CH═C— R1, R | 05/03/2005 |
| 6750244 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 06/15/2004 |
| 6730519 | Method of preparing delta-9-tetrahydrocannabinol A method for the isolation of delta-9-tetrahydrocannibinol (THC) from, Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained including the steps of extracting the Cannabis plant material, chelating delta-9-THC acid on alumina solid suppor... | 05/04/2004 |
| 6696569 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C--C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enz... | 02/24/2004 |
| 6620842 | Chalcones Disclosed are novel chalcone derivatives having the formula (I) ##STR1## The compounds possess antiproliferative activity and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the ut... | 09/16/2003 |
| 6608089 | Derivatives of flavones, xanthones and coumarins Compounds having the formula (I) Z--OCH2 --C.ident.CCH2 --NRR1 (I) or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B). ##STR1## The compounds possess antiproliferative act... | 08/19/2003 |
| 6472414 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters... | 10/29/2002 |
| 6465625 | Taxol derivatives Highly specific biocatalytic reactions have been used to create a population of taxol derivatives.... | 10/15/2002 |
| 6403812 | 4, 7-Dichlorofluorescein dyes as molecular probes Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 2',4',5',7'-tetrachloro-4,7-dicloro-5- (and 6-) carboxyfluoresceins... | 06/11/2002 |
| 6372907 | Water-soluble rhodamine dye peptide conjugates The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye... | 04/16/2002 |
| 6365416 | Method of preparing delta-9-tetrahydrocannabinol A method of preparing THC using extraction of plant material with a non-polar solvent followed by vacuum distillation and chromatography.... | 04/02/2002 |
| 6355650 | (3R,4R)-Ɗ8-tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)-Ɗ8 -tetrahydrocannabi... | 03/12/2002 |
| 6340691 | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors Compounds of the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.... | 01/22/2002 |
| 6329377 | Ketomethylene group-containing cysteine and serine protease inhibitors The present invention is directed to novel ketomethylene group-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/11/2001 |
| 6288234 | Multibinding inhibitors of microsomal triglyceride transferase protein Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compounds contain from 2 t... | 09/11/2001 |
| 6245807 | Treatment of human prostate disease We have now discovered that unexpectedly compounds of the following formulae I or 11 can be used to selectively stimulate the death of mammalian prostate cells, including both epithelial cell and prostate cancer cells, and thus are useful in treating pros... | 06/12/2001 |
| 6211201 | Multivalent salts of pyridostigmine and related compounds A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some other purpose. Numerous modifications are contemplated, inclu... | 04/03/2001 |
| 6191278 | Water-soluble rhodamine dyes and conjugates thereof The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye... | 02/20/2001 |
| 6172058 | Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo... | 01/09/2001 |
| 6166226 | Synthesis of aryl ethers A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. ... | 12/26/2000 |
| 6136961 | Biocatalytic methods for synthesizing and identifying biologically active compounds Highly specific biocatalytic reactions have been used to create a population of derivatives from a single starting compound. Examples demonstrate synthesis of derivatives of taxol, taxol-2'-adipate, taxol-2'-vinyl adipate, 2,3-(methylenedioxy) benzaldehyd... | 10/24/2000 |
| 6127415 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especiall... | 10/03/2000 |
| 6124484 | Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis The present invention provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.... | 09/26/2000 |
| 6054448 | 2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' ... | 04/25/2000 |
| 5977077 | Xanthone analogs for the treatment of infectious diseases Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also disclosed are methods for the treatment of infectious diseases us... | 11/02/1999 |
| 5965605 | Inhibition of the binding human IgE to its receptor by tetracyclic compounds for the alleviation of IgE-mediated immune response Disclosed are chemical agents with unexpected activity to inhibit the interactions between human immunoglobulin E (IgE) and its receptor (Fc&3xb5;RI) which interactions are known to be involved in triggering allergic responses. The agents may be used to m... | 10/12/1999 |
