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| Number | Title | Issue Date |
| 8067621 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bo... | 11/29/2011 |
| 7678929 | Furochroman derivatives Disclosed are furochroman compounds of formula I liquid-crystal media which contains the compounds of formula I, and the use of the media in electro-optical displays, in particular in VAN LCDs. ... | 03/16/2010 |
| 7414126 | Process for the preparation of topiramate The present invention relates to a process for the preparation of topiramate, intermediates in this process and a process for the preparation of these intermediates. ... | 08/19/2008 |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7196209 | Continuous process for the preparation of fructopyranose sulfamate derivatives The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein R1, R3, R | 03/27/2007 |
| 7157589 | One step process for the preparation of anticonvulsant derivatives The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R | 01/02/2007 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 6774142 | Inhibition by 3-deoxyflavonoids of T-lymphocyte activation and therapies related thereto 3-Deoxyflavonoid compounds and methods for inhibiting T-cell activity and treating diseases and disorders (e.g., autoimmune disorders, inflammatory disorders, diabetes, ALS, MS, rheumatoid arthritis, etc.). In some cases the efficacy and/or duration of action of lut... | 08/10/2004 |
| 6737439 | Aromatase inhibitors from Broussonetia papyrifera A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammal... | 05/18/2004 |
| 6696578 | Difuropyrone derivatives A novel cartilage-specific compound and methods of diagnosis in medical and veterinary contexts using the compound. Screening methods for therapeutic substances and methods of treatment are also provided.... | 02/24/2004 |
| 6602903 | Substituted heterocyclic compounds The invention relates to compounds of formula (I): ##STR1## and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.... | 08/05/2003 |
| 6465625 | Taxol derivatives Highly specific biocatalytic reactions have been used to create a population of taxol derivatives.... | 10/15/2002 |
| 6399653 | Ring fused dihydropyrans, process for preparation and use thereof The invention relates to compounds of the formula I ##STR1## in which the radicals R1, R2, R3 and A have the meaning mentioned in the description. The invention further relates to a process for the preparation of the compo... | 06/04/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6365610 | Ozonide compounds with inhibitory activity for urokinase production and angiogenesis The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor ##STR1## wherein A is an... | 04/02/2002 |
| 6300339 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein A, B, Q, T, X, Y, Z, R5, R6, R7, R8, Ar, k, m, n and p are as defined in the specification. These compounds are useful in treating or pr... | 10/09/2001 |
| 6262083 | Genipin derivative having liver protection activity The present invention relates to novel genipin derivatives which have an excellent liver protection activity with little cytotoxicity, and these compounds are so stable in vivo that they do not induce any side effects.... | 07/17/2001 |
| 6255324 | Amino-and mercurio-substituted 4',5'-dihydropsoralens and therapeutical uses thereof 5'-substituted, 4',5'-dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. ##STR1## Also described are 2-substituted mercurimethyl-2-3-dihydro-benzofurans of ... | 07/03/2001 |
| 6225478 | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient Novel iridoid derivatives represented by general formula (I): ##STR1## and a vascularization inhibitor having for its active ingredient said derivative are disclosed. This vascularization inhibitor has remarkable vascularization inhibitory effects unaccom... | 05/01/2001 |
| 6136961 | Biocatalytic methods for synthesizing and identifying biologically active compounds Highly specific biocatalytic reactions have been used to create a population of derivatives from a single starting compound. Examples demonstrate synthesis of derivatives of taxol, taxol-2'-adipate, taxol-2'-vinyl adipate, 2,3-(methylenedioxy) benzaldehyd... | 10/24/2000 |
| 6071946 | Tricyclic urea compounds A compound selected from those of formula (I): ##STR1## in which A, Y, R1, R2 and R3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal aff... | 06/06/2000 |
| 6034239 | Tricyclic compounds, their production and use A compound of the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydroc... | 03/07/2000 |
| 6034120 | Insect antifeedant for agriculture The present invention provides an antifeedant and a contact insecticide using the components contained in Cyperaceae species. In particular, the present invention provides an insect antifeedant and a contact insecticide comprising as an active ingredient ... | 03/07/2000 |
| 6034256 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A1, A2, A3, A4, R, R",... | 03/07/2000 |
| 6022888 | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient Novel iridoid derivatives represented by general formula (I): and a vascularization inhibitor having for its active ingredient said derivative are disclosed. This vascularization inhibitor has remarkable vascularization inhibitory effects unaccompanied by... | 02/08/2000 |
| 5998461 | Tricyclic amide compounds This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.... | 12/07/1999 |
| 5986114 | Benzopyranol derivatives The invention relates to benzopyranol derivatives which are intermediates in a process for stereoselectively forming N-substituted dihydro-2,3 benzodiazopines which are useful as AMPA receptor antagonists. The process includes an opening reduction step wh... | 11/16/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5856529 | Benzofuran and dihydrobenzofuran melatonergic agents Novel derivatives of benzofuran and dihydrobenzofuran are provided which are useful as melatonergic agents.... | 01/05/1999 |
| 5773609 | Photoactivatable compositions and to methods for the diagnosis and treating medical conditions A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo... | 06/30/1998 |
| 5702645 | Photochromic chromene derivatives Described herein are photochromic compounds or a structural isomer of the photochromic compound, the photochromic compounds represented by the formula: ##STR1## wherein R1, R2, R4, R5, R6, R... | 12/30/1997 |
| 5686485 | Physiologically active EI-1941 compounds The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R1 and R2 is hydrogen and the other is hydroxy, or R1 | 11/11/1997 |
| 5646175 | Carbamoyloxylabdane compounds Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions thereof are disclosed.... | 07/08/1997 |
| 5639889 | Asymmetric epoxidation reaction A process for producing an optically active benzopyran compound of the formula [I] or [II]: ##STR1## in which an olefin compound of the formula [V] or [VI]: ##STR2## is subjected to asymmetric epoxidation reaction, using, as a catalyst, an ... | 06/17/1997 |
| 5428027 | Substituted semicarbazone arthropodicieds Certain substituted semicarbazones, including all geometric and stereoisomers thereof, agricultural compositions containing them and their use as arthropodicides.... | 06/27/1995 |
| 5418232 | Diazabicycloalkene derivatives A compound of formula (I) possesses excellent potassium channel opening activity and is effective on various diseases arising from contractions of blood vessels, bronchial smooth muscles, etc., for example, ischemic heart diseases exemplified by angina pe... | 05/23/1995 |
| 5409952 | Heterocyclic compounds: 2-styryl-4H-1-benzopyran-4-ones A compound of the formula (I) ##STR1## in which: R1 represents a hydrogen atom, a lower alkyl group, a hydroxy group or a lower alkoxy group, R2, R3, R4, R5, R6, R7, R8 | 04/25/1995 |
| 5391751 | 2,2-dimethylchromene derivatives, process for their preparation and pharmaceutical compositions in which they are present The present invention relates to 2,2-dimethylchromene derivatives of the formula: ##STR1## in which Z represents a halogen atom or a cyano, nitro, acetyl, phosphono or dialkoxyphosohoryl group, the alkoxy group containing 1 to 3 carbon atoms, an... | 02/21/1995 |
| 5387700 | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-ଲ-D-fructopyranose and (1-methylcyclohexyl)methanol A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-ଲ-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an a... | 02/07/1995 |
| 5356929 | Reduced and quaternized psoralens as photo-activated therapeutics The invention features phototherapeutic compositions comprising Type 1, Type 2, or Type 3 psoralens and methods of using such compounds for treatment of proliferative diseases of skin, blood and bone marrow.... | 10/18/1994 |
