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| Number | Title | Issue Date |
| 7915432 | Method for improving the shelf-life of hematoxylin staining solutions A method is provided for improving the shelf-life of a nuclear staining solution. In particular, the present invention provides a method of adding an antioxidant to a hematoxylin staining solution which maintains the performance of the stain over its shelf-life.... | 03/29/2011 |
| 7723532 | Pharmaceutical compositions 3 The invention provides compositions comprising formula 1 steroids, e.g., 16α-bromo-3β-hydroxy-5α-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. The compositions are useful to make imp... | 05/25/2010 |
| 7297801 | Process for the production of 2-oxa-3-one androstane derivatives The present invention relates to processes for the production of 2-oxa-3-one androstane derivatives. The processes comprise reacting a 3-one androstane derivative with ozone to form a 2-oxa-3-one androstane derivative. ... | 11/20/2007 |
| 7244760 | Methods for preparation and use of psorospermin analogs Psorospermin is a cytotoxic dihydroflranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method... | 07/17/2007 |
| 7179927 | Extraction method There is disclosed a method for treating a source of azadirachtin: (a) dissolving said sample in an organic polar solvent; (b) combining the solution of step (a) with an organic non-polar solvent to form a single phase containing the said solvents and dissolved samp... | 02/20/2007 |
| 7074943 | Oxygen-containing heterocyclic fused naphthopyrans This invention relates to novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the i, j, or k side of the naphthopyran ring, having certain substituents at the 2, 5, and 6 positions of the naphthopyran ring. These naphthopyrans may have ... | 07/11/2006 |
| 7036932 | Laminated functional wafer for plastic optical elements A functional wafer of the present invention is disclosed to solve manufacturing difficulties involved in the production of optical elements such as polycarbonate ophthalmic lenses. The functional wafer may include a front layer, a functional layer, and a back layer,... | 05/02/2006 |
| 6963003 | Oxygen-containing heterocyclic fused naphthopyrans This invention relates to novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the i, j, or k side of the naphthopyran ring, having certain substituents at the 2, 5, and 6 positions of the naphthopyran ring. These naphthopyrans may have ... | 11/08/2005 |
| 6949537 | PI-3 kinase inhibitor prodrugs The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 09/27/2005 |
| 6933396 | Process to prepare psorospermin Psorospermin and analogs thereof are made using an enantiomerically selective process ... | 08/23/2005 |
| 6927234 | Xanthone derivatives, method of production thereof, and pharmaceutical composition containing the same Biologically active xanthone derivatives, as well as compositions prepared from such derivatives, possessing anti-cancer activity, anti-inflammatory activity, anti-obesity activity, and/or hair growth promotion activity, and a method for producing such derivatives a... | 08/09/2005 |
| 6872840 | Synthesis of 8-membered carbocyclic compound having diexomethylene groups The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by... | 03/29/2005 |
| 6787659 | Process for the production of oxandrolone The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one; (b) hydroxylating the 17β-hydroxy-17α-methyl-5α-an... | 09/07/2004 |
| 6723858 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 04/20/2004 |
| 6719925 | Naphthopyrans with a heterocycle in the 5, 6-position, preparation, and (co)polymer compositions and matrices containing them The present invention relates to novel compounds of the naphthopyran type with a fused heterocycle in the 5,6-position. These compounds have formula (I) or (II) given below: These compounds (I) or (II) have valuable phot... | 04/13/2004 |
| 6608215 | Oxygen-containing heterocyclic fused naphthopyrans Novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the f, i, j, or k side of the naphthopyran ring. These naphthopyrans may have the formula (I) presented below: ##STR1## These compounds (I) have interesting photochromic pro... | 08/19/2003 |
| 6593480 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 07/15/2003 |
| 6589980 | Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure ##STR1## wherein X, Y1, Y2, Y3, Y4, Z1, Z2, Z3, and Z4 are as defined in the sp... | 07/08/2003 |
| 6398987 | Naphthopyrans having a perfluoroalkyl substituent in position 5, preparation and compositions and matrices containing them The present invention relates to novel compounds of the naphthopyran type which have a perfluoroalkyl group (X) in position 5. These compounds are of formula (I) given below: ##STR1## These compounds (I) possess interesting photochromic properties. The ... | 06/04/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6365610 | Ozonide compounds with inhibitory activity for urokinase production and angiogenesis The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor ##STR1## wherein A is an... | 04/02/2002 |
| 6342459 | Photochromic naphthopyrans The present invention relates to photochromic 2H-naphtho[1,2-b]pyrans as well as their use in synthetic resins of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic naphthopyran compounds, for which... | 01/29/2002 |
| 6329534 | Glucocorticoid receptor antagonists for treatment of diabetes Compounds of formula I ##STR1## are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, composi... | 12/11/2001 |
| 6268520 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 07/31/2001 |
| 6166066 | Cannabinoids selective for the CB2 receptor Disclosed are novel cannabinoids which are selective for the CB2 receptor. The novel cannabinoids comprise a substituted or unsubstituted tricyclic cannabinoid core and a substituted or unsubstituted C5-C8 carbocyclic ring, five to eight-membered heterocy... | 12/26/2000 |
| 6133288 | Pentacyclic compounds, intermediates, processes, compositions, and methods The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR5 --; Y is --O--, --S--, --CH2 --, --CH2 CH2 --, --CH.dbd.CH--, or --NR5 --; B is --CH2 | 10/17/2000 |
| 6113812 | Photochromic articles A photochromic article that includes a host material and a photochromic amount of a benzopyran compound, the benzopyran compound represented by one of the formulas: ##STR1## wherein R1, R2, R3, R4, R5 | 09/05/2000 |
| 6057341 | Bi-aromatic dibenzofuran derivatives and their use in human and veterinary medicine and in cosmetics The invention concerns novel bi-aromatic dibenzofuran derivatives of formula (I),and their use in pharmaceutical compositions for human or veterinary medicine (skin, rheumatic respiratory, cardiovascular, and ophthalmologic disorders), or in cosmetic comp... | 05/02/2000 |
| 6034256 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A1, A2, A3, A4, R, R",... | 03/07/2000 |
| 5998464 | 4-Oxa and 4-thia steroids The compounds of the present invention are those of structural formula (I) ##STR1## wherein X is oxygen or sulfur. Pharmaceutical compositions and methods of use of the compounds in the treatment of hyperandrogenic conditions are disclosed. In additi... | 12/07/1999 |
| 5958970 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple cond... | 09/28/1999 |
| 5948817 | Polycyclic ethyl alkylamide melatonergic agents Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH2)n, wherein n is 1-4; X=O, CH2, or CH (when a double bond is present); R=... | 09/07/1999 |
| 5888432 | 2-Adamantyl benzopyrans the compositions and (co)polymer matrices containing them The present invention has for subjects, novel benzopyran derivatives, substituted in position 2 with an adamantyl group as well as the compositions and (co)polymer matrices containing such derivatives. Said derivatives possess interesting photochromic pro... | 03/30/1999 |
| 5869662 | Photochromic benzopyran compounds Benzopyran compounds represented by the formulas: ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are selected from hydrogen, a stab... | 02/09/1999 |
| 5811034 | 7-methylidene-5-oxo-furo fused naphthopyrans Described are novel 7-methylidene-5-oxo-furo fused naphthopyran compounds having certain substituents at the 2 position of the pyran ring. Also described are polymeric organic host materials that contain or that are coated with such compounds.... | 09/22/1998 |
| 5792389 | Water soluble laser dyes Novel water soluble dyes of the formula I are provided ##STR1## wherein R1 and R4 are alkyl of 1 to 4 carbon atoms or hydrogen; or R1 -R2 or R2 -R4 form part of aliphatic heterocyclic ... | 08/11/1998 |
| 5783116 | Derivatives of carbocyclic fused naphthopyrans Described are novel pentahydrophenanthro9,10-b!pyrans and tetrahydrocyclopentac!-naphtho1,2-b!pyrans. Also described are polymeric organic host materials that contain or that are coated with such compounds.... | 07/21/1998 |
| 5756773 | Triterpene derivatives of azadirachtin having insect antifeedant and growth inhibitory activity The invention discloses novel triterpene derivatives of azadirachtin of the formulae 2 to 11 of the drawings and a process for isolating new triterpene derivatives of azadirachtin from the various parts of the neem plant (Azadirachta indica A-Juss), which... | 05/26/1998 |
| 5747530 | Aromatic dibenzofuran compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active dibenzofuran compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (II) to (VI): ##STR2## and are useful for the treatment of a wide variety of disease s... | 05/05/1998 |
| 5744070 | Photochromic substituted naphthopyran compounds Described are novel reversible photochromic naphthopyran compounds, examples of which are 3H-naphtho2,1-b!pyrans having an acyl or aroyl oxy-bearing substituent at the number 6 carbon atom and certain substituents at the 3-position of the pyran ring. Ce... | 04/28/1998 |
