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| Number | Title | Issue Date |
| 7288665 | Process for selective derivatization of taxanes Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(... | 10/30/2007 |
| 7256219 | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to multifluoro-substituted Chalcones and analogs thereof, represented by the general Formula I: wherein Ar and R6-R10 are defined herein. The present invent... | 08/14/2007 |
| 7202370 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and th... | 04/10/2007 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 6849733 | Neuropeptide-Y ligands There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of... | 02/01/2005 |
| 6743914 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/01/2004 |
| 6710075 | Therapeutic compounds and methods The present invention provides compounds having a cyclopentabenzofuran core and the use of such compounds in therapy as well as compositions comprising said compounds. ... | 03/23/2004 |
| 6562966 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or d... | 05/13/2003 |
| 6562967 | Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or d... | 05/13/2003 |
| 6177389 | Detergent compositions comprising orthocarbonate pro-fragrances The present invention relates to orthocarbonate pro-fragrances useful for delivery of sustained perfume or fragrance to fabric treated with a laundry detergent composition which comprises the herein described pro-fragrances. The orthocarbonate pro-fragran... | 01/23/2001 |
| 5856523 | Purifying cyclic esters by aqueous solvent extraction and further purification A process is provided for the production and purification of cyclic esters in which the purification includes the introduction of an aqueous solvent into a cyclic ester containing composition and allowing two phases to form. A first phase includes cyclic ... | 01/05/1999 |
| 5686630 | Purifying cyclic esters by aqueous solvent extraction A process is provided for the production and purification of cyclic esters in which the purification includes the introduction of an aqueous solvent into a cyclic ester containing composition and allowing two phases to form. A first phase includes cyclic ... | 11/11/1997 |
| 5675022 | Recovery of dioxanone by melt crystallization Processes are disclosed for the recovery of 1,4-dioxanone by melt crystallization from a feed containing impurities capable of initiating the polymerization of 1,4-dioxanone, e.g., diethylene glycol. The processes of the present invention utilize melt cry... | 10/07/1997 |
| 5656576 | Reducing polyethercyclocpolyol metal adhesion Reducing the adherence of polyethercyclicpolyol to metal by exposing the metal to a selected surfactant.... | 08/12/1997 |
| 5435841 | Insolubilizers for binders in paper coating compositions This invention relates generally to insolubilizers for use with binders in paper coating compositions. There is provided a process for preparing both an insolubilizer and paper coating composition containing the insolubilizer and a binder which, when appl... | 07/25/1995 |
| 5420304 | Method to produce cyclic esters Disclosed is a novel integrated process for production of cyclic esters which includes recovery of starting materials, such as lactic acid from a dilute aqueous lactic acid-containing solution, by solvent extraction. The starting materials are then formed... | 05/30/1995 |
| 5412116 | Oxidation of glycoside substituted taxanes to taxol or taxol precursors and new taxane compounds formed as intermediates A process for the conversion of glycoside substituted taxanes to taxol and related compounds that can serve as precursors to taxol. The process includes the oxidation of glycoside substituted taxanes to convert the glycoside to the hydroxyl group. The oxi... | 05/02/1995 |
| 5356928 | Cytotoxic agents The invention relates to pharmaceutical compositions comprising an effective cytotoxic amount of: ##STR1## Wherein R represents Ac or H; R' represents: ##STR2## OH; and R" represents: ##STR3## these new compounds demonstrate surprising... | 10/18/1994 |
| 5319107 | Method to produce cyclic esters Disclosed is a method for producing cyclic esters by the conversion of hydroxy carboxylic acids and their derivatives to their respective cyclic esters. Such cyclic esters, including lactide or glycolide, are particularly useful for producing polymers whi... | 06/07/1994 |
| 5274127 | Lactide production from dehydration of aqueous lactic acid feed The present invention is directed to a method for making L-lactide from aqueous L-lactic acid. Aqueous lactic acid feed for present purposes comprehends an aqueous mixture of one or more of L1 A, L2 A, and L3 A, optionally... | 12/28/1993 |
| 5223534 | Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as benzofuranyl/benzofuranylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest ... | 06/29/1993 |
| 5223532 | Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino derivatives Non-peptidyl compounds characterized generally as chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of... | 06/29/1993 |
| 5219881 | Cyclic ether derivatives The invention concerns a cyclic ether derivative of the formula I, ##STR1## wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene; Ar2 is... | 06/15/1993 |
| 5217991 | Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are ... | 06/08/1993 |
| 5216013 | Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are compounds of the formula ##STR1## whe... | 06/01/1993 |
| 5166367 | Antipsychotic benzodioxan derivatives A compound of the formula: ##STR1## wherein the dotted line represents optional unsaturation; R1 and R2 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, alkanamido ... | 11/24/1992 |
| 5008406 | Hemiacetal compounds and the applications thereof The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups: --C2 H4 | 04/16/1991 |
| 4827003 | Hemiacetal compounds and the applications thereof The invention relates to compounds of formula: ##STR1## in which m, n, p and q are equal to 0 or 1, p being different from q and the sum m+n+p+q being equal to 2, A denotes a nonionic chain arrangement chosen from the groups: in which r denotes a num... | 05/02/1989 |
| 4755323 | Liquid-crystalline dielectrics New 1,4-dioxanes of the formula I ##STR1## wherein R1 and R2 each signify and alkyl group with 1 - 10 C-atoms, wherein one or two CH2 groups can also be replaced by O-atoms, F, Cl, Br or CN, R2 also H, A | 07/05/1988 |
| 4656296 | Novel compounds and their use as insolubilizers for binders for paper coating compositions Paper coating compositions contain at least one pigment, at least one binder, and, as an insolubilizer for the binder, the product of the reaction of glyoxal and a vicinal polyol.... | 04/07/1987 |
| 4584383 | Substituted 2-mercapto-imidazoles and their preparation The invention provides novel 1-substituted-5-hydroxymethyl-2-mercapto-imidazoles of the formula ##STR1## wherein R is pyridylmethyl, alkyl of 1 to 4 carbon atoms, or a radical of formula: ##STR2## in which R1 is hydrogen or halog... | 04/22/1986 |
| 4578486 | Smoking compositions containing a dicarbonate ester flavorant-release additive A smoking tobacco composition having incorporated therein a dioxane compound as a flavorant-release additive which under normal smoking conditions imparts improved flavor to mainstream smoke and improved aroma to side-stream smoke.... | 03/25/1986 |
| 4547580 | Dioxane compounds and their use as insolubilizers for binders for paper coating compositions Paper coating compositions contain at least one pigment, at least one binder, and, as an insolubilizer for the binder, the product of the reaction of glyoxal and a vicinal polyol.... | 10/15/1985 |
| 4238500 | Cyclic double hemiacetals of enediol compounds and compositions and methods for preparing and using same Novel chemical compounds of the general formulae: ##STR1## wherein R1 and R2 are hydrogen, alkyl, cycloalkyl, aryl or arylalkyl, wherein R3 through R10 are hydrogen, alkyl, or aryl, wherein R5 an... | 12/09/1980 |
| 4200765 | Glycol aldehyde and ethylene glycol processes A process for preparing glycol aldehyde by reacting formaldehyde, hydrogen and carbon monoxide at elevated temperature and superatmospheric pressure in the presence of rhodium catalyst and conversion thereof to ethylene glycol as the substantially exclusi... | 04/29/1980 |
