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| Number | Title | Issue Date |
| 8076494 | Process for the manufacture of epoxy triazole derivatives Disclosed is a process for the manufacture of a compound of formula (I) wherein Hal represents fluoro or chloro, and R1 and R2 represent, independently from one another, hydrogen or Hal; in which proce... | 12/13/2011 |
| 8008513 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 08/30/2011 |
| 7989643 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon at... | 08/02/2011 |
| 7442811 | Process for the preparation of dioxane acetic acid esters Process for the preparation of an ester of formula (1), wherein R1 represents a leaving group, CN, OH or a COOR5 group, R3 and R4 each independently represent a 1-3 C alkyl group, and R2 and R5 each i... | 10/28/2008 |
| 7439046 | Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one α-hydrogen atom and a substituted or unsubstituted aldehyde i... | 10/21/2008 |
| 7371855 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 05/13/2008 |
| 7361771 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 04/22/2008 |
| 7354950 | 1,3-Dioxane derivatives, composition, optical element and display device containing the same A composition includes at least one compound represented by the following Formula (1). In the Formula (1), R1 represents an alkyl group having 1 to 18 carbon atoms, R2 represents a hydrogen atom or a substituent, and R3 represents a ... | 04/08/2008 |
| 7244853 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable... | 07/17/2007 |
| 7238826 | Boronate esters The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin, rosuvastatin, pitavastatin, and fluvastatin. ... | 07/03/2007 |
| 7208623 | Process for the manufacture of HMG-CoA reductase inhibitory mevalonic acid derivatives The invention relates to a process for the manufacture of a compound of formula: (Formula I); or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element (a) represents —CH2—CH2— ... | 04/24/2007 |
| 7205418 | Process for the preparation of optically active 2-[6-(substituted alkyl)-1,3-dioxan-4-yl]acetic acid derivatives The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-β-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula... | 04/17/2007 |
| 7183408 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 02/27/2007 |
| 7176323 | Process for the production of γ-keto acetals A process for the production of a γ-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: ... | 02/13/2007 |
| 7161004 | Processes to produce intermediates for rosuvastatin Intermediate compounds for preparing rosuvastatin are prepared by a process comprising oxidizing hydroxy groups to aldehyde groups, using sodium hypochlorite and 2,2,6,6-tetramethyl piperidinyl oxy free radical (TEMPO) as a catalyst. ... | 01/09/2007 |
| 7157255 | Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises ei... | 01/02/2007 |
| 7045641 | Process for preparing polyenedialdehyde monoacetals A process for preparing compounds of the formula I is described and entails converting a compound of the formula II by Wittig or Wittig-Horner reaction into ... | 05/16/2006 |
| 6933393 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 08/23/2005 |
| 6933385 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives. ... | 08/23/2005 |
| 6903225 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required... | 06/07/2005 |
| 6870059 | Process for the preparation of 2-(6-substituted-1,-3-dioxane-4-yl)acetic acid derivatives The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula (1), where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon ... | 03/22/2005 |
| 6803488 | Process for producing fluorinated ketone The present invention provides a process whereby fluorinated ketones of various structures can be produced by short process steps and which is useful as an industrial production process. Namely, it is a process for producing a fluorinated ketone of the follow... | 10/12/2004 |
| 6610216 | OPTICALLY ACTIVE COMPOUND, PHOTOREACTIVE CHIRAL AGENT, LIQUID CRYSTAL COMPOSITION, METHOD FOR CHANGING HELICAL STRUCTURE OF LIQUID CRYSTAL, METHOD FOR FIXING HELICAL STRUCTURE OF LIQUID CRYSTAL, LIQUID CRYSTAL COLOR FILTER, OPTICAL FILM, AND RECORDING MEDIUM The present invention provides an optically active compound represented by the following general formula (1), a photoreactive chiral agent, a liquid crystal composition, a liquid crystal color filter, an optical film, and a recording medium which include ... | 08/26/2003 |
| 6610892 | Process for preparing 2,7-dimethyl-2,4,6-octatrienal monoacetals The invention relates to a process for preparing 2,7-dimethyl-2,4,6-octatrienal monoacetals of the general formula I ##STR1## which comprises a) condensing an ester phosphonium salt of the general formula II or an ester phosphonate of the general form... | 08/26/2003 |
| 6528538 | Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharamaceutical compositions and preparation process The present invention relates to cyclic compounds which are of the class of compounds of formula I wherein X and Y represent an oxygen atom and to processes for preparing such compounds. The compounds are useful in the treatment of dyslipidemia, atheroscl... | 03/04/2003 |
| 6515149 | Acetal compound, polymer, resist composition and patterning response Acetal compounds in which a 5- or 6-membered ring acetal structure is connected to a norbornene structure through a linker represented by --(CH2)m -- in which one hydrogen atom may be substituted with a hydroxyl or acetoxy group, and... | 02/04/2003 |
| 6472544 | Process for the preparation of optically active 2-[6-hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as th... | 10/29/2002 |
| 6344569 | Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives The present invention provides a process which can produce an important intermediate for the production of the HMG coenzyme A reductase inhibitor atrovastatin, 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives, with ease industrially and in good yields,... | 02/05/2002 |
| 6331641 | Process for producing simvastatin This invention provides an easy and efficient process for producing a simvastatin of great use as an HMG-CoA reductase inhibitor, which comprises deacylation of lovastatin with an inorganic base and a secondary or tertiary alcohol and subjecting the resul... | 12/18/2001 |
| 6268488 | Prodrug activation using catalytic antibodies The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compo... | 07/31/2001 |
| 6184376 | Synthesis of acyclic nucleoside derivatives Methods and novel intermediates of the formula: ##STR1## wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are --CH2 CH2 --, --CH2 CH2 CH2 | 02/06/2001 |
| 6156905 | Deoxy epothilones and intermediates utilized in the process for preparing epothilones The invention relates to a process for the production of epothilones and intermediate products within the process. Epothilones A and B are natural substances, which can be produced by microorganisms, and the taxols have similar properties and are thus of ... | 12/05/2000 |
| 6057458 | Production of 3-alkoxyalkanals by hydroformylation of enol ether substrates The present invention provides a process for producing an optically active aldehyde which comprises hydroformylating a terminal olefin substrate represented by the formula: Q1 Q2 C.dbd.CH2 wherein Q1 is an atom or gr... | 05/02/2000 |
| 6022938 | Compounds with isocyanate groups and masked groups reactive in relation to isocyanates Isocyanato compounds with capped, isocyanate-reactive groups are those of the formula I ##STR1## where R1 and R2 are hydrogen, C1 -C10 -alkyl, C6 -C10 -aryl or C7 -C10 | 02/08/2000 |
| 5877332 | Reactive adducts of vinyldioxo compounds New adducts are produced from the reaction of vinyl dioxo compounds with anhydrides, epoxyesters, lactones, and lactams, and such adducts are useful for preparing curable coating compositions.... | 03/02/1999 |
| 5824484 | RXR homodimer formation The invention provides a method of screening a substance for the ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the presence of homodimer... | 10/20/1998 |
| 5739374 | Processes of preparing diphenylheteroalkyl derivatives Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 04/14/1998 |
| 5677432 | Immunological detection of organophosphates A compound useful for forming immunoconjugates used in the detection of organophosphate pesticides is provided. The compound has the formula ##STR1## wherein X is selected from the group consisting of R--O--, R--S-- and R--NH--, where R is an optiona... | 10/14/1997 |
| 5656619 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for ... | 08/12/1997 |
| 5606079 | Process for the selective hydroformylation of terminal olefin groups and its use in the preparation of 1,4-butanedial monoacetal A process for producing 1,4-butanedial monoacetal by reacting acrolein acetal with a synthesis gas containing carbon monoxide and hydrogen, in the presence of a rhodium catalyst and an accelerator of formula (I) ##STR1## wherein R1 and R | 02/25/1997 |
