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| Number | Title | Issue Date |
| 7777057 | Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3... | 08/17/2010 |
| 7645891 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2b, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G... | 01/12/2010 |
| 7371855 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 05/13/2008 |
| 7361771 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 04/22/2008 |
| 7186848 | Polymorphs of a 1-pyrrole derivative, intermediate for the preparation of atorvastatin The invention relates to new crystalline forms I and II of (4R-cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluoro-phenyl)-5-(1- methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester of the Formula (I) and a process for t... | 03/06/2007 |
| 7183408 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 02/27/2007 |
| 7119116 | Derivatives of dioxane-2-alkyl carbamates, preparation thereof and application thereof in therapeutics A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1–... | 10/10/2006 |
| 7109381 | Aldehydes containing a difluorooxymethylene bridge Aldehydes containing a difluorooxymethylene bridge, of the general formula I OHC-(A11)m-Z11-(A12-Z12)n-(A13-Z13)p-A14I and the use and p... | 09/19/2006 |
| 7084293 | Process of synthesis of compounds having nitrile functions from ethylenically unsaturated compounds The present invention relates to a process of hydrocyanation of ethylenically unsaturated organic compounds to compounds having at least one nitrile function, particularly the hydrocyanation of diolefins such as butadiene, or of substituted olefins such as alkene ni... | 08/01/2006 |
| 7034165 | Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothil... | 04/25/2006 |
| 6933393 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 08/23/2005 |
| 6861561 | Substituted aromatic policyclic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aromatic polycyclic tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and o... | 03/01/2005 |
| 6821960 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorde... | 11/23/2004 |
| 6812352 | Multidentate phosphite ligands, catalytic compositions containing such ligands, and catalytic processes utilizing such catalytic compositions Multidentate phosphite ligands are disclosed for use in reactions such as hydrocyanation and isomerization. The catalyst compositions made therefrom and the various catalytic processes which employ such multidentate phosphite ligands are also disclosed. In particula... | 11/02/2004 |
| 6632484 | Dialkyne compounds Described are dialkyne compounds of the formula I ##STR1## in which n, m, R1, R2, X1, X2, X3, X4, Z1, Z2, A1, A2, Q, Y1 and Y2 a... | 10/14/2003 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6562807 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases ... | 05/13/2003 |
| 6528538 | Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharamaceutical compositions and preparation process The present invention relates to cyclic compounds which are of the class of compounds of formula I wherein X and Y represent an oxygen atom and to processes for preparing such compounds. The compounds are useful in the treatment of dyslipidemia, atheroscl... | 03/04/2003 |
| 6458829 | Substituted γ-phenyl-Ɗ-lactones and analogs thereof and uses related thereto γ-Phenyl-substituted Ɗ-lactones and analogs thereof, including lactams, are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease states.... | 10/01/2002 |
| 6365755 | Ammonium 3,5,6-trihydroxyhexanoate derivatives and preparation process thereof Provided are a novel ammonium (3R,5S)-3,5,6-trihydroxyhexanoate derivative represented by the following formula (I): ##STR1## wherein R1 represents a benzyl group which may have a substituent, a triphenylmethyl group which may have a substituen... | 04/02/2002 |
| 6303194 | Acetylene derivatives, and liquid-crystalline medium The invention relates to acetylene derivatives of the formula I ##STR1## in which n, m, R1, R2, X1, X2, X3, X4, Z1, Z2, A1, A2, Q, Y1 and Y... | 10/16/2001 |
| 6294680 | Process for the production of semi synthetic statins via novel intermediates A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared ... | 09/25/2001 |
| 6271398 | Process for producing simvastatin and/or its derivatives A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side... | 08/07/2001 |
| 6235786 | Reverse hydroxamate inhibitors of matrix metalloproteinases Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.... | 05/22/2001 |
| 6177576 | Pyruvate saccaride ketals A novel composition for supplementing the human diet having a polyol-derived pyruvate (2-keto-propionic-acid) moeity as a component.... | 01/23/2001 |
| 6174707 | Process for producing L-allysine acetals The present invention has for its object to provide a method for producing an L-allysine acetal which involves a fewer steps and is efficient. This invention relates to method for producing an L-allysine acetal which comprises; converting a D,L-allysine acetal... | 01/16/2001 |
| 6166064 | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity A compound of formula (I) ##STR1## wherein R1 and R2 are as defined in the description, R2 being an aromatic group, useful in the treatment and condition selected from the group consisting of the group meningitis and ... | 12/26/2000 |
| 6100407 | Process for producing simvastatin and/or its derivatives A process for the production of simvastatin and its analogues that is efficient, economical and convenient involves the use of hydroxyl protected intermediates of formula (III) or (VII). These intermediates allow for direct alkylation of the butyrate side... | 08/08/2000 |
| 6022938 | Compounds with isocyanate groups and masked groups reactive in relation to isocyanates Isocyanato compounds with capped, isocyanate-reactive groups are those of the formula I ##STR1## where R1 and R2 are hydrogen, C1 -C10 -alkyl, C6 -C10 -aryl or C7 -C10 | 02/08/2000 |
| 5969154 | Liquid crystalline diketopyrrolopyrroles A liquid crystalline compound of formula ##STR1## wherein B and D are each independently of the other C6 -C24 alkyl, ##STR2## L is ##STR3## methyl or C10 -C18 alkyl, wherein R1 is ... | 10/19/1999 |
| 5922739 | 5-Naphthalen-1-yl-1,3-dioxane derivatives, preparation and therapeutical use thereof Compounds of general formula (I) ##STR1## in which R1 represents a hydrogen atom or a (C1 -C4)alkyl, (C3 -C6)cycloalkylmethyl or phenyl-(C1 -C3)alkyl group optionally substi... | 07/13/1999 |
| 5744569 | One-component and two-component polyurethane coating compositions In one-component and two-component polyurethane coating compositions comprising at least one reactive component capable of reacting with polyisocyanates, the reactive component is a compound A) containing an isocyanate group, a urethane, thiourethane or u... | 04/28/1998 |
| 5739374 | Processes of preparing diphenylheteroalkyl derivatives Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 04/14/1998 |
| 5718845 | Tricyanovinyl substitution process for NLO polymers Nonlinear optical compounds which contain a heteroaromatic ring and may further comprise a tricyanovinyl group attached to the heteroaromatic ring.... | 02/17/1998 |
| 5691372 | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention a... | 11/25/1997 |
| 5670666 | Process for preparing intermediates for the synthesis of D1 antagonists Disclosed are a process and intermediates of the formulae ##STR1## wherein X- is halide, BF4-, R3 SO3-, wherein R3 is C1 -C6 alkyl, CF3, C1... | 09/23/1997 |
| 5658942 | Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienyle... | 08/19/1997 |
| 5656619 | Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for ... | 08/12/1997 |
| 5604256 | Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition Compounds of formula (I): ##STR1## (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen,... | 02/18/1997 |
| 5600001 | Acetaldehyde derivatives, their preparation process and their use Azines of formula (I): ##STR1## in which R and R' either are identical and represent an alkyl radical containing 1 to 4 carbon atoms or an alkenyl radical containing 3 to 5 carbon atoms, or together form a radical of formula (II): --CHR1 -... | 02/04/1997 |
