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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 7518003 | Production process of tetrahydropyran compound and tetrahydropyran compound produced by the production process The invention provides a production process of a tetrahydropyran compound, characterized by allowing 3,4-dihydro-2-alkoxy-2H-pyran compound or tetrahydro-2-alkoxy-2H-pyran compound which can be easily prepared through reaction between acrolein and alkylvinylether, w... | 04/14/2009 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7351730 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 04/01/2008 |
| 7326797 | Manufacture of isoflavones A process for manufacturing a hydroxylated isoflavone of the formula (I) given in the description comprises re-acting an appropriately substituted 2-hydroxydeoxybenzoin of the formula (II), also given in the description, with a formic acid anhydride of the formula H... | 02/05/2008 |
| 7291367 | Liquid-crystalline compounds The invention relates to liquid-crystalline compounds of the formula (I) in which R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, a, b and c have the meanings indicated in Claim | 11/06/2007 |
| 7265230 | Herbicides Compounds of formula I wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/... | 09/04/2007 |
| 7244853 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable... | 07/17/2007 |
| 7166728 | Process for preparation of nerol oxide The present invention relates to a process for the synthesis of racemic nerol oxide i.e. 3,6-dihydro-4-methyl-2-[2-methyl-1-propenyl)-2H-pyran from monoterpene alcohol nerol i.e. cis-3,7-dimethylocta-2,6-diene-1-ol. ... | 01/23/2007 |
| 7160852 | Polyalklbicylic derivatives The compound according to the formula set forth below and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed. ... | 01/09/2007 |
| 7144918 | Biologically active macrolides, compositions, and uses thereof The present invention provides a compound of the formula (I). The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically acceptable carrier, alone or in combination with at least one a... | 12/05/2006 |
| 7138429 | Flavonoid compound and process for producing the same A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial fermentation treatment with Aspergillus saitoi. ... | 11/21/2006 |
| 7122535 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them A method of treating pain in a warm-blooded animal comprising administering to anwarm-blooded animal in need thereof an amount of a compound of the formula wherein the substituents are defined in accordance with the di... | 10/17/2006 |
| 7105685 | Cannabinol derivatives The invention provides cannabinol derivatives and pharmaceutical preparations thereof. ... | 09/12/2006 |
| 7081279 | Alkenyl compound having a negative Δε value, liquid crystal composition, and liquid crystal display device Liquid crystalline compounds having a large negative Δε low viscosity, a large K33/K11 value, a small Δε/Δ⊥ and mutually excellent solubility even at low temperature, compositions containing at least one of the compounds and liquid cryst... | 07/25/2006 |
| 7064221 | Process for producing pyran This invention provides a process for producing a pyran efficiently with high productivity and simplified production facilities. The process for producing a pyran comprises reacting aldehyde (I) represented by: R1—CHO (I) | 06/20/2006 |
| 7053209 | High viscosity liquid controlled delivery system and medical or surgical device The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials c... | 05/30/2006 |
| 6974607 | Pyrans as liquid crystals Tetrahydropyran derivatives having at least one ester group (—CO—O—) and at least one group —CN, —NCS, —F, —Cl, —OCHF2, —OCF3, —CF3, —OCHFCF3, —OCF | 12/13/2005 |
| 6939886 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8 | 09/06/2005 |
| 6936726 | Flavanol and cysteamine conjugates The present invention refers to new products generated by the conjugation of flavanols with molecules that contain the thiol group. New molecules are obtained from polyphenolic plant extracts rich in oligomeric and polymeric procyanidines and prodelfinidins. In this... | 08/30/2005 |
| 6933385 | Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives. ... | 08/23/2005 |
| 6930200 | Multicomponent synthesis of amino acids and derivatives thereof Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1: N(R4R5)C(R2R3... | 08/16/2005 |
| 6902777 | Liquid-crystalline medium A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at lea... | 06/07/2005 |
| 6900160 | Triazolo-epothilones The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ... | 05/31/2005 |
| 6887737 | Epoxidized acetals and thioacetals, episulfidized acetals and thioacetals, and reworkable thermosetting resin compositions formulated therefrom This invention relates to epoxidized acetals and thioacetals, episulfidized acetals and thioacetals, thermosetting resin compositions based on such epoxidized acetals and thioacetals, episulfidized acetals and thioacetals, reaction products of which are controllably... | 05/03/2005 |
| RE38723 | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells The subject invention provides substrates useful for analyzing the metabolic activity in cells by improving the retention of a detectable reporter molecule only in intact cells where a particular enzyme is present. In particular, improved retention results from a tw... | 04/12/2005 |
| 6867309 | Red-emitting organic electroluminescent compound A red-emitting organic electroluminescent compound, the structure of the compound as follows: wherein n is an integer of 1˜6; Ar represents aryl or heteroaryl; R1 and R2 ... | 03/15/2005 |
| 6864225 | Cyclic ketals, fragrance compositions containing the same and methods of using the same Compounds of the general formula (I) are described: wherein each of R1, R2, R3, R4, R5 and R6 independently represents a substituent selected from the g... | 03/08/2005 |
| 6818638 | Melvinolin derivatives Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1 interactions. ... | 11/16/2004 |
| 6809088 | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them The invention relates to new derivatives of 2-(iminomethyl)amino-phenyl which are NO synthase inhibitors and can trap reactive oxygen species. These compounds can notably be used for the treatment of stroke, of neurodegenerative diseases and of ischemic or hemorragi... | 10/26/2004 |
| 6808762 | Oxabicyclooctanes The present invention relates to oxabicyclooctanes of the general formula I. in which R1, R2, A1, A2, A3, A4, L1... | 10/26/2004 |
| 6800654 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are eachH, alkyl,, alkanoyl, halo, OH, aryl optionally substituted with R8 | 10/05/2004 |
| 6784228 | Epoxy resin composition, cured article thereof, novel epoxy resin, novel phenol compound, and process for preparing the same The present invention relates to an epoxy resin composition a cure article thereof, a novel epoxy resin used therein, a polyhydric phenol compound suited for used as an intermediate thereof, and a process for preparing the same. One of the objects to be achieved by ... | 08/31/2004 |
| 6762198 | Dihetero-substituted metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): | 07/13/2004 |
| 6713622 | 4,7-dichlororhodamine dye labeled polynucleotides A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R1-R6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfo... | 03/30/2004 |
| 6693178 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present... | 02/17/2004 |
| 6692944 | Chemo-enzymatic synthesis of optically enriched rose-oxides The present invention relates to a process for the systhesis of optically enriched dextro- and laevo-rotatory isomers of rose oxide from racemic citronellol. The invention particularly relates to the preparation of optically enriched (-)-(2 S, 4 R)-rose o... | 02/17/2004 |
| 6686348 | Metalloprotease inhibitors A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, halogen, alkyl or alkoxy, X represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents any one of the groups described in the description, their isomers and a... | 02/03/2004 |
| 6683215 | N-(4-carbamimidoyl-phenyl)-glycine derivatives The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: ##STR1## wherein R1, E, X1 to X4 and G1 and G2 are as defined in the description and the claims... | 01/27/2004 |
| 6664259 | Il-8 receptor antagonists This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 12/16/2003 |
| 6649227 | Difluorovinyl compound, liquid crystal composition and liquid crystal display Provided are liquid crystalline compounds having a wide liquid crystal phase temperature range, low viscosity, a large elastic constant ratio K33 /K11 and excellent solubility at low temperature, a liquid crystal composition using th... | 11/18/2003 |
