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| Number | Title | Issue Date |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7368567 | Arylsulfonyl benzodioxanes, benzoxazines and benzothiazines as 5-HT6 antagonists Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R1, R2, R3, R4, R5 and R6 are as defi... | 05/06/2008 |
| 7319155 | 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds useful in the synthesis of non-steroidal analogues of vitamin D Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): are useful intermediates in the synthesis of non-steroidal derivatives of vitamin D. ... | 01/15/2008 |
| 7235519 | 1,2-substituted 2,3-dehydro-1H-5,9-dioxyacyclohepta[f]inden-7-ones and 7-substituted benzo[b]dioxepin-3-ones The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions. ... | 06/26/2007 |
| 7179927 | Extraction method There is disclosed a method for treating a source of azadirachtin: (a) dissolving said sample in an organic polar solvent; (b) combining the solution of step (a) with an organic non-polar solvent to form a single phase containing the said solvents and dissolved samp... | 02/20/2007 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 7022664 | 1,2 Substituted 2,3-dihydro-1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3-ones The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions. ... | 04/04/2006 |
| 6849746 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 02/01/2005 |
| 6821977 | Antidiabetic agents A compound of the formula whereon R1 is: R5 is: and n, m,... | 11/23/2004 |
| 6723753 | Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle... | 04/20/2004 |
| 6710089 | Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle... | 03/23/2004 |
| 6448295 | Use of substituted N-fused-phenyl-N-benzyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating... | 09/10/2002 |
| 6407100 | Fungicidal aromatic oximes The invention relates to novel compounds of the formula ##STR1## in which R1 is C1-4 alkyl and (Y--X) is CH2, C1-2 alkylthio-CH.dbd. or C1-2 alkyl-ON.dbd. and Z is an aldimino or ketimino group, and t... | 06/18/2002 |
| 6369099 | Method of locking 1 -OH of vitamin D compounds in axial orientation A method of modifying or altering the structure of a 1-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1-hydroxyl in... | 04/09/2002 |
| 6180659 | Tracheal smooth muscle relaxant The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient. ##STR1## [In the formula, X and Y each is any group se... | 01/30/2001 |
| 6160005 | Medicament for circadian rhythm sleep disorder A preventive and/or therapeutic medicament for circadian rhythm sleep disorders such as jet lag syndrome which comprises as an active ingredient an alkylenedioxybenzene derivative represented by the following formula (I) wherein m represent an integer of ... | 12/12/2000 |
| 5998408 | Triterpene derivatives with immunosuppressant activity The compounds of Formula I ##STR1## are useful as immunosuppressive agents.... | 12/07/1999 |
| 5990321 | Monoesters and macrocyclic diester of phthalic acid and synthesis thereof Monoesters and macrocyclic diesters of 2,2,4-trimethyl-1,3-pentanediol and phthalic acid or a derivative thereof are described. Methods by which such monoesters and diesters may be prepared are also described. The mono- and diesters according to the inven... | 11/23/1999 |
| 5981571 | Benzodioxa alkylene ethers as melatonergic agents Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.... | 11/09/1999 |
| 5939452 | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists The invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists of formula I and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds, and to a meth... | 08/17/1999 |
| 5817692 | Endoperoxides useful as antiparasitic agents The present invention relates to novel biologically-active organic peroxides and to novel uses of both known and new organic peroxides. More specifically, this invention details organic endoperoxides having antiparasitic activity, methods for their prepar... | 10/06/1998 |
| 5770180 | Bridge-substituted tropanes for methods of imaging and therapy Disclosed are bridge-substituted analogs of tropanes and benztropines as well as methods for: imaging of cocaine receptors; treatment of cocaine abuse; and imaging and treatment of Parkinson's disease.... | 06/23/1998 |
| 5719182 | Endothelin receptor anatagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists.... | 02/17/1998 |
| 5672624 | Endoperoxides useful as antiparasitic agents The present invention relates to novel biologically-active organic peroxides and to novel uses of both known and new organic peroxides. More specifically, this invention details organic endoperoxides having antiparasitic activity, methods for their prepar... | 09/30/1997 |
| 5646148 | HIV protease inhibitors useful for the treatment of AIDS Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ... | 07/08/1997 |
| 5565582 | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal motility stimulating properties, compositions containing ... | 10/15/1996 |
| 5530021 | Hydrazine derivative and pesticidal composition comprising said derivative as an effective ingredient A novel hydrazine derivative and a pesticidal composition containing the hydrazine derivative as the effecting ingredient. The hydrazine derivative show high pesticidal activity against harmful pests which are resistant to known pesticides such as organop... | 06/25/1996 |
| 5496847 | Aminomethyl-benzodioxane and benzopyran serotonergic agents Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.... | 03/05/1996 |
| 5442060 | Carboxamide derivatives Carboxamide derivatives of the following general formula (I): ##STR1## (wherein R1 and R2 are C1 -C3 alkyl group or both taken together C1 -C3 alkylene group, R3 is hydrogen atom... | 08/15/1995 |
| 5420273 | Condensed heterocyclic compounds The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, ind... | 05/30/1995 |
| 5391570 | Aminomethyl-benzodioxane and benzopyran serotonergic agents Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.... | 02/21/1995 |
| 5387681 | Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides This invention provides a novel process for the synthesis of bicyclic aromatic sulfonic acids employing reacting a bicyclic aromatic compound with sulfur trioxide-N,N-dimethylformamide complex in the presence of a water miscible, non-reactive solvent. The... | 02/07/1995 |
| 5310946 | Cyclic peroxyacetal lactone, lactol and ether compounds A process for preparing a compound containing (a) peroxyacetal lactone, (b) peroxyacetal lactol or (c) peroxycacetal ether functionality comprising oxygenating in the presence of one or more oxidizing metal catalysts a compound containing (i) hydroperoxy ... | 05/10/1994 |
| 5283359 | Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof The preparation of arylethanolamines, and in particular albuterol (salbutamol), together with their novel boron, acetal and hemi-acetal intermediates is described.... | 02/01/1994 |
| 5274157 | Protected formylpentanediols, hydroxymethylpentanediols, process for their preparation and intermediates Compounds of the formula Ib ##STR1## in which R1 and R2 independently of one another are linear or branched C1 -C12 alkyl, cycloalkyl having 5 to 8 ring carbon atoms, phenylalkyl having 1 to 4 C atoms in th... | 12/28/1993 |
| 5272172 | Iridoid derivatives and the use thereof as a drug Iridoid derivatives synthesized using genipin, which is an aglycon of geniposide, as the starting material are useful as an anti-hyperlipemia agent and as a cholagogue.... | 12/21/1993 |
| 5272144 | Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C1 -C6 alkyl;... | 12/21/1993 |
| 5233057 | Biphenyl derivatives, process for preparing the same and intermediates therefor Novel biphenyl derivatives of the formula: ##STR1## wherein R1 is a substituted or unsubstituted aminocarbonyl group, aminothiocarbonyl group, a substituted or unsubstituted lower alkoxycarbonyl group, cyano group, or a group of the formul... | 08/03/1993 |
| 5225607 | Insecticidal ethers This invention relates to novel fluorinated ethers, useful as insecticides and acaricides, to processes and intermediates for their preparation, to insecticidal and acaricidal compositions thereof and to methods of combating and controlling insect and aca... | 07/06/1993 |
| 5214191 | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase 2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase.... | 05/25/1993 |
