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| Number | Title | Issue Date |
| 7910750 | Artemisinin (qinghaosu) derivatives, their preparation methods and their use, and pharmaceutical compositions containing the same The invention provides a type of artemisinin derivatives having following structure I, its preparation method and use, as well as a pharmaceutical composition containing such artemisinin derivatives and its use. The arteminsinin derivatives of the present invention ... | 03/22/2011 |
| 7425356 | Chiral compounds The invention relates to chiral compounds of formula I wherein X1, X2, X1, X2, x1, x2, y1, y2, B, C, U1, U2, V1, V2, W1 and... | 09/16/2008 |
| 7417156 | Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in one additional step into four different dimers (4-7). Alcohol and ... | 08/26/2008 |
| 7417155 | Artemisinine derivatives, and uses thereof for treating malaria A new artemisinin derivatives, of following general formula (I): In which: a and b represent a single or a double bond, n1 and n2 represent 0 or 1, | 08/26/2008 |
| 7223450 | Chiral compounds The invention relates to chiral compounds of formula I wherein X1,X2,X1,X2,x1,x2,y1,y2,B,C,U1,U2,V1,V2,W1 and W2 | 05/29/2007 |
| 7214538 | Device and method for the determination of lithium ion concentration in a biological fluid The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of ... | 05/08/2007 |
| RE39593 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions. ... | 04/24/2007 |
| 7205401 | Compositions and methods for separating amines and amino acids from their counter-enantiomers Diketo- and pyridine-containing chiral crown ligands having at least two chiral bulky groups attached to two different chiral carbon atoms of the crown that are covalently bonded to or coated on suitable solid supports, and further coated by hydrophobic organic solv... | 04/17/2007 |
| 7179927 | Extraction method There is disclosed a method for treating a source of azadirachtin: (a) dissolving said sample in an organic polar solvent; (b) combining the solution of step (a) with an organic non-polar solvent to form a single phase containing the said solvents and dissolved samp... | 02/20/2007 |
| 7166226 | Ion exchange cryptands covalently bound to substrates One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond th... | 01/23/2007 |
| 7112685 | Labeled resiniferatoxin derivatives This invention relates resiniferatoxin derivatives useful in a vanilloid receptor binding assay and methods for production thereof. ... | 09/26/2006 |
| 7105708 | Method for producing compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the resultant bis(alkylthio)c... | 09/12/2006 |
| 7098242 | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of ... | 08/29/2006 |
| 7022664 | 1,2 Substituted 2,3-dihydro-1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3-ones The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions. ... | 04/04/2006 |
| 6951846 | Artemisinins with improved stability and bioavailability for therapeutic drug development and application A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, β-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic ... | 10/04/2005 |
| 6924380 | Calixarenes and calixarence-based sensors A calixarene dimer of the general formula (I-G), comprising a first calixarene moiety I and a second calixarene moiety G, wherein: L is [—CH2—] or [—O—CH2—O—] and is the same or different between each aryl group; R5 is H,... | 08/02/2005 |
| 6916940 | Method for producing cyclic carboxylic orthoester fluorides and corresponding compounds The invention relates to a process for the preparation of cyclic carboxylic acid orthoester fluorides in which a) at least one bis(alkylthio)carbenium salt is reacted with at least one organic compound containing at least two hydroxyl groups in the pres... | 07/12/2005 |
| 6867295 | Ion exchange cryptands covalently bound to substrates One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond th... | 03/15/2005 |
| 6790863 | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents This invention comprises compositions containing dihydroartemisinin and dihydroartemisitene dimers with activity as anticancer agents and anti-protozal, including anti-malarial and anti-leishmanial properties. This invention also describes methods of preparation of ... | 09/14/2004 |
| 6750356 | Single pot conversion of artemisinin into arteether The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presen... | 06/15/2004 |
| 6686479 | Compositions and methods for selectively binding amines or amino acid enantiomers over their counter-enantiomers Naphthyl crown ether ligand molecules containing at least two naphthyl groups that are covalently bonded to suitable solid supports and coated by hydrophobic organic solvents are disclosed. These compositions and associated methods are characterized by se... | 02/03/2004 |
| 6685972 | Process for isolating artemisinin from Artemisia annua The present invention relates to a process for the isolation of artemisinin, an antimalarial agent from the herb of the Artemisia annua plant, comprising of extracting the herb with ethanol, partitioning of the extract between water and hexane, followed b... | 02/03/2004 |
| 6683193 | Single pot conversion of artemisinin into artemether The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.... | 01/27/2004 |
| 6677463 | Single pot conversion of artemisinin to artesunic acid The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by esterification of the reduced product at room temperature.... | 01/13/2004 |
| 6649647 | Trioxane derivatives This invention relates to compounds containing a trioxane moiety, especially certain artemisinin derivatives, which have cytotoxic and antitumour activity and their use in the treatment of cancer. Some of these compounds comprise a ligand which is capable... | 11/18/2003 |
| 6610216 | OPTICALLY ACTIVE COMPOUND, PHOTOREACTIVE CHIRAL AGENT, LIQUID CRYSTAL COMPOSITION, METHOD FOR CHANGING HELICAL STRUCTURE OF LIQUID CRYSTAL, METHOD FOR FIXING HELICAL STRUCTURE OF LIQUID CRYSTAL, LIQUID CRYSTAL COLOR FILTER, OPTICAL FILM, AND RECORDING MEDIUM The present invention provides an optically active compound represented by the following general formula (1), a photoreactive chiral agent, a liquid crystal composition, a liquid crystal color filter, an optical film, and a recording medium which include ... | 08/26/2003 |
| 6586464 | Artemisinin analogs having antimalarial, antiproliferative, and antitumor activities and chemoselective methods of making the same Methods for producing novel artemisinin analogs and artemisinin dimers having antimalarial, antiproliferative and antitumor activities are described herein. These novel artemisinin analogs and artemisinin dimers have the following structure ##STR1## ... | 07/01/2003 |
| 6485984 | CALIXCROWN DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, A SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES PREPARED BY USING THE SAME AND A PROCESS FOR IMMOBILIZING A PROTEIN MONO-LAYER BY USING THE SELF-ASSEMBLED MONO-LAYER OF THE CALIXCROWN DERIVATIVES The present invention is to provide calixcrown derivatives of formulae 1 to 3 requisite for the preparation of a self-assembled monolayer as well as a process for the preparation thereof. Further the present invention is to provide a self-assembled monola... | 11/26/2002 |
| 6403347 | HIV integrase inhibitors Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts... | 06/11/2002 |
| 6346631 | Process for the preparation of arteethers from dihydroartemisinin The invention relates to an improved process for the preparation of arteether. The process comprises dissolving dihydroartemisinin in dry ethanol, adding a solid acid catalyst with trialkylorthoformate in the reaction mixture, stirring the reaction mixtur... | 02/12/2002 |
| 6337944 | Polymeric optical waveguide doped with a lanthanide-sensitizer complex The invention relates to a polymeric waveguide comprising a lanthanide ion-sensitizer complex, characterized in that the lanthanide ion is preferably neodymium(III) ion (Nd3+), ytterbium(III) ion (Yb3+), or erbium(III) ion (Er3+... | 01/08/2002 |
| 6326394 | Calixarene tubes as cation receptors A cyclic compound of formula (I) ##STR1## wherein Rx groups which may be the same or different are selected from --O--(CH2)n --O-- where n is an integer of from 2-6; Ry and Rz groups which may be the ... | 12/04/2001 |
| 6307068 | Artemisinin derivatives, method for the preparation thereof and pharmaceutical compositions containing the same The invention relates to compound of the general formula (I): R--O--A (I) wherein: R represents the radical of formula (II): ##STR1## A is as defined in the description, and medicinal products containing the same which are useful in treating or in preventing ... | 10/23/2001 |
| 6300371 | Rameswaralide and rameswaralide derivatives A diterpene derivative compound, having the formula I, II, or III, compositions, and therapeutic compositions containing the compounds are disclosed. Also disclosed are methods for treating an inflammatory disorder by providing an inflammatory inhibiting ... | 10/09/2001 |
| 6214865 | Macrocyclic analogs and methods of their use and preparation The invention provides halichondrin analogs having pharmaceutical activity, such as anticancer or antimitotic (mitosis-blocking) activity, and methods of identifying agents that induce a sustained mitotic block in a cell after transient exposure of the ce... | 04/10/2001 |
| 6180105 | Method for producing an extract containing artemesinin A method of preparation of an artemisinin extract comprising the steps of extraction of Artemisia annua with liquid carbon dioxide and allowing the carbon dioxide to evaporate from the resultant mixture.... | 01/30/2001 |
| 6160004 | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## ... | 12/12/2000 |
| 6156790 | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## ... | 12/05/2000 |
| 6120700 | Hydrocyanation of diolefins and isomerization of nonconjugated 2-alkyl-3-monoalkenenitriles Improved liquid phase process useful in the hydrocyanation of diolefinic compounds to produce nonconjugated acyclic nitriles and to the liquid phase process of isomerization of the nitrites to, among other things, 3- and/or 4-monoalkene linear nitriles. T... | 09/19/2000 |
| 6090826 | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity Compounds of the formula ##STR1## where R1 and R2, independently are alkyl groups having 2 to 8 carbons; R3 is hydrogen or lower alkyl; X is S, O or N--R4 where R4 is hydrogen or lower alkyl; Y i... | 07/18/2000 |
