Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7838691 | Palmerolides: methods of preparation and derivatives thereof Organic compounds having Formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a phar... | 11/23/2010 |
| 7439264 | Therapeutic compounds This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also rel... | 10/21/2008 |
| 7339006 | Metathesis-active adhesion agents and methods for enhancing polymer adhesion to surfaces The invention discloses an adhesion agent composition comprising at least one C3-C200 olefin compound having at least one metathesis active double bond, wherein the olefin is substituted or unsubstituted; and at least one compatibilizing functi... | 03/04/2008 |
| 7250392 | Surfactant blend for cleansing wipes A cleansing product containing: (a) a water insoluble substrate; and (b) a surfactant composition impregnated onto the substrate, the composition containing: (i) at least one lathering surfactant; and (ii) at least about 40% by weight, based on the weight of the com... | 07/31/2007 |
| 7241755 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein,... | 07/10/2007 |
| 7214538 | Device and method for the determination of lithium ion concentration in a biological fluid The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of ... | 05/08/2007 |
| 7205332 | Deoxoartemisinin analogs, process for their preparation, and anticancer agent comprising them The present invention relates to a new deoxoartemisinin dimer and trimer, which have excellent anticancer activity and lower toxicity and are stable to acids, to a new deoxoartemisinin monomer of intermediate thereof, to preparations thereof, and to anticancer agent... | 04/17/2007 |
| 7183246 | Cleaning/disinfectant composition to clean surfaces A composition and method for cleaning surfaces having deposits, such as drink water tanks, supply water wells, water filter systems, and distributor water lines. The composition contains in combination a cleaning solution and a disinfectant, such as hydrogen peroxid... | 02/27/2007 |
| 7094913 | Synthesis of 7-membered carbocyclic compound having diexomethylene groups The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by t... | 08/22/2006 |
| 7053109 | Aminediols for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/30/2006 |
| 7022664 | 1,2 Substituted 2,3-dihydro-1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3-ones The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions. ... | 04/04/2006 |
| 6965034 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates ... | 11/15/2005 |
| 6903210 | Washing disinfectant for hygienic and surgical hand disinfection A disinfectant composition and process for making the same. The composition comprises octenidine dihydrochloride, at least one C1 to C8-alkyl alcohol, at least one surfactant chosen among non-ionic or cationic surfactants, water and optionally ... | 06/07/2005 |
| 6723858 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 04/20/2004 |
| 6605599 | Epothilone derivatives The present invention relates to epothilone derivatives, having the following formula ##STR1## in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1 -R7 are as defined herein, method... | 08/12/2003 |
| 6603023 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are int... | 08/05/2003 |
| 6544945 | Cyclic pro-perfumes having modifiable fragrance raw material alcohol release rates The present invention relates to cyclic pro-perfumes comprising a moiety derived from a fragrance raw material alcohol. Such cyclic perfumes may contain dioxolane and glucosyl orthesters that are suitable for use in delivering enhanced fragrance longevity... | 04/08/2003 |
| 6369099 | Method of locking 1 -OH of vitamin D compounds in axial orientation A method of modifying or altering the structure of a 1-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1-hydroxyl in... | 04/09/2002 |
| 6355674 | Aminotetralins as 5-HT1D Agonists A class of novel aminotetralins is disclosed useful as 5-HT1D agonists.... | 03/12/2002 |
| 6331563 | N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl, Sulfanyl, Sulfinyl or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 12/18/2001 |
| 6307067 | Palladium and boron co-catalyzed addition of oxygen nucleophiles to vinyl epoxides Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 1,2-diols and oxygen-containing h... | 10/23/2001 |
| 6306895 | Substituted oxygen alicyclic compounds, including methods for synthesis thereof The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen comp... | 10/23/2001 |
| 6294679 | Intermediate for the synthesis of prostaglandins An enantiomerically enriched compound of formula 1, ##STR1## wherein Ar is phenyl optionally substituted with one or more groups selected from haloalkyl, alkyl and halide. This compound can be isolated in crystalline form, and used in the preparation of (... | 09/25/2001 |
| 6294390 | Covalently immobilized fluoroionophores for optical ion sensors Compounds, constructed in modular manner, of formula (I), ##STR1## wherein I is the monovalent residue of an ionophore, F is the monovalent residue of a fluorophore, G is a functional group, T is a trivalent organic radical and R01, R02 and R | 09/25/2001 |
| 6284900 | Cis-isoambrettolide of high degree of isomer purity and use thereof The invention relates to a molecule which is of important olfactory interest for perfumers. This molecule, i.e. the cis-isoambrettoide, which has a high degree of isomer purity belongs to the group of macrocyclic lactones with a musk odor. The invention a... | 09/04/2001 |
| 6201133 | Certain cyclic thio substituted acylaminoacid amide derivatives Disclosed are compound of formula I ##STR1## wherein R represents hydrogen, lower alkyl, cycloalkyl, bicycloalkyl, adamantyl, aryl, biaryl, or mono- or di-(cycloalkyl, aryl or biaryl)-lower alkyl, di-(lower alkyl or aryl-lower alkyl)amino-lower alkyl, or ... | 03/13/2001 |
| 6130349 | Catalytic compositions and methods for asymmetric allylic alkylation Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. Such compositions provide a versatile ... | 10/10/2000 |
| 6068834 | Skin lightening compositions This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure: ##STR1## wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl... | 05/30/2000 |
| 6063939 | Process for preparing unsaturated cyclic ethers Unsaturated cyclic ethers of the formula I ##STR1## where Z is --(CHR4)q -- or --(CHR4)q --O--, q is 0, 1, 2 or 3 and R1,R2,R3,R4 are hydrogen or C1 -C4 | 05/16/2000 |
| 6015899 | Liquid antioxidants as stabilizers Products are described which can be obtained by reacting components a), b) and c), where component a) is a compound of the formula I or a mixture of compounds of the formula I, component b) is a compound of the formula II or a mixture of compounds of the ... | 01/18/2000 |
| 5998613 | 4-aminotetrahydrobenzisoxazole or -isothiazole compounds The present invention relates to novel 4-aminotetrahydrobenzisoxazoles or 4-aminotetrahydrobenziothiazoles having gamma-aminobutanoic acid (GABA)-uptake inhibiting activity and thus useful in the treatment of analgesia, psychosis, convulsions, anxiety, ep... | 12/07/1999 |
| 5952501 | Certain tricyclic substituted diazabicylo3.2.1! octane derivatives This invention encompasses compounds of the formula: where either R1 or R2 represents ##STR1## and the other represents hydrogen or straight or branched chain lower alkyl having 1-6 carbon atoms; and X is oxygen, methylene, or N... | 09/14/1999 |
| 5936100 | Synthesis of functionalized macrocycles by ring closing metathesis The invention concerns an improved process for the preparation of macrocyclic products with 12 or more ring atoms containing one or more polar functional groups on the ring and/or one or more heteroatoms within the ring by ring closing metathesis (RCM) of... | 08/10/1999 |
| 5922863 | Diene cyclization using ruthenium and osmium carbene complexes Disclosed are ruthenium and osmium carbene compounds which are stable in the presence of a variety of functional groups and which can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins. Specifically, the present inven... | 07/13/1999 |
| 5783711 | Process for the preparation of heterocyclic aldehydes Preparation of heterocyclic aldehydes I ##STR1## (A, B=optionally substituted methylene groups; m, n=1 to 5; m+n>2), by hydrogenation of carboxylic acids IIa ##STR2## or one of their esters IIb derived from a C1 -C10 alcoho... | 07/21/1998 |
| 5770180 | Bridge-substituted tropanes for methods of imaging and therapy Disclosed are bridge-substituted analogs of tropanes and benztropines as well as methods for: imaging of cocaine receptors; treatment of cocaine abuse; and imaging and treatment of Parkinson's disease.... | 06/23/1998 |
| 5750733 | Hydroxy containing alkyl glycamides, low foaming detergent compositions comprising such and a process for their manufacture The present invention relates to novel hydroxy-containing alkyl glycamide surfactants and detergent composition comprising said surfactants. Since they surprisingly provide low foam, these surfactants can be used as cleansing surfactants in applications w... | 05/12/1998 |
| 5746933 | Lubricating oil and composition for refrigerating machine, and refrigerating machine A lubricating oil for refrigerating machines comprises polyoxyalkylene compounds represented by the formula (I): ##STR1## Wherein A is a residue obtained from a compound which has both a heterocyclic ring having an ether linkage therein and hydroxyl ... | 05/05/1998 |
| 5739022 | Copper(II) nuclease compounds, compositions, and kits A method is provided for nonoxidatively cleaving the phosphorus-oxygen linkage of nucleic acids and certain anticholinesterases such as insecticides using a macrocyclic copper(II) complex. A composition suited for such cleavage is also provided.... | 04/14/1998 |
| 5698715 | Preparation of unsaturated cyclic ethers A process for the preparation of unsaturated cyclic ethers of the general formula I ##STR1## in which Z denotes --(CHR4)q or --(CHR4)q --O-- q is 0, 1, 2 or 3 and R1, R2, R3, and... | 12/16/1997 |
