Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7589218 | Chiral spiro compounds and their use in asymmetric catalytic reactions The present invention provides a chiral ligand, represented by a formula or its enantiomer: X and X′ can be independently O, NH, NR, NCOR or S; each of Z1-Z7 and Z1′-Z7′ can... | 09/15/2009 |
| 7518002 | High purity phthalein derivatives and method for preparing same The invention concerns high purity phthalcin derivatives enabling their use for medical applications or in the field of biotechnology, as well as their preparation method whereby a phthatic anhydride derivative is condensed with a naphthol or phenol derivative in an... | 04/14/2009 |
| 7323577 | Process for producing benzofuran derivative A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, o... | 01/29/2008 |
| 7196191 | Catalytic oxidation of C—H bonds The invention provides a catalytic, chemospecific and stereospecific method of oxidizing a wide variety of substrates without unwanted side reactions. Essentially, the method of the instant invention, under relatively mild reaction conditions, catalytically, stereos... | 03/27/2007 |
| 7138427 | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed ... | 11/21/2006 |
| 6806283 | Selective serotonin receptor antagonists and therapeutic applications thereof Spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SPAN) and derivatives thereof are provided as selective serotonin receptor antagonists. The compounds are selective, high affinity antagonists of 5-HT2 serotonin receptors. The compounds are useful as anti... | 10/19/2004 |
| 6420130 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe... | 07/16/2002 |
| 6310091 | Fungicidal saponin, CAY-1, and isolation thereof from Capsium species fruit A novel antifungal compound, "CAY-1", was isolated from the dried fruit of Capsicum frutescens (cayenne pepper), purified to homogeneity, and characterized as a novel sterol glycoside (a saponin) with a molecular mass of 1243.35 Da. CAY-1 demonstrates ant... | 10/30/2001 |
| 6166034 | Spiro piperidine derivatives as 5HT1D receptor antagonists Novel spiro piperdine derivatives of formula (I), in which P1, P2, R1, R2, R2 ', R3, m, A, E, G, X, Y, R7, R8, R9 and R10 have the meanings defined in... | 12/26/2000 |
| 6133279 | Therapeutic agents for renal diseases and organ preservatives Herein disclosed are therapeutic agents for renal diseases and organ preservatives containing a compound represented by the general formula (1): ##STR1## wherein X represents an oxygen atom or a group represented by the general formula (2): ... | 10/17/2000 |
| 5874592 | Physiologically active substance EI-2128-1 The present invention relates to a novel compound EI-2128-1 having IL-1 production inhibitory activity which is represented by formula (I): ##STR1##... | 02/23/1999 |
| 5786492 | Halichondrins Halichondrin derivatives, isolatable from a marine sponge of the Lissodendoryx Sp., have cytotoxic preparations and are of the formula: ##STR1## wherein R1 and R2 together form a spiro attached ring system selected from the grou... | 07/28/1998 |
| 5688826 | Excitatory amino acid derivatives Compounds for formula I ##STR1## in which X represents O, NRa, S, SO or SO2 and R is as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and pharmaceutically acceptable salts thereof are... | 11/18/1997 |
| 5663373 | 4-alkoxy-2, 6-di-t-butylphenol derivatives Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R1 is a hydrogen atom or an acyl group; R2 is a lower alkyl group; R3 is a hydrogen atom or a low... | 09/02/1997 |
| 5646308 | Benzopyran derivatives Benzopyran derivatives represented by formula (I): ##STR1## wherein X represents .dbd.O, .dbd.S, .dbd.N--Z, etc. (Z represents a lower alkyl group, etc.); Y represents a substituted amino group, an alkoxy group, an alkylthio group, etc., and R1 | 07/08/1997 |
| 5637709 | Photochromatic substances Polychromatic compounds of pyrans having a substituted adamantane or a polycyclic ring system, with the exception of adamantane, in the 2-position of the pyran ring, having the structure ##STR1## whereby the residues R1 -R4 are ... | 06/10/1997 |
| 5328929 | Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 A black Spongia sp. in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancer) growth inhibitors named spongistatin 2 and spongistatin 3. A bright colored Southwest Indian Ocean sponge Spirastrella sp... | 07/12/1994 |
| 5260414 | Spirobislactone acrylate polymers This invention is directed to a thermoplastic polymer that is solid at room temperature and which expands on further polymerization, to form a crosslinked polymer, and to a process for preparing the polymer and the crosslinked polymer. In a preferred embo... | 11/09/1993 |
| 5091413 | Antibiotic agent An antibiotic agent produced by the cultivation of Dictyochaeta simplex is described. The compound has broad antifungal activity and antipneumocystis activity.... | 02/25/1992 |
| 5057590 | Bislactone curing agents for epoxy resins and polymers obtained therefrom Bislactone curing agents are used to cure and copolymerize with epoxy-based esins. Preferably, the copolymerization is performed using a tertiary amine catalyst. During cure, the bislactone ring opens and expands. The use of bislactones as curing agents fo... | 10/15/1991 |
| 4945171 | Xanthene dyes having a fused (C) benzo ring Synthesis and applications of fluorescent dyes which are derivatives of benzo[c]xanthenes is described. The dyes exhibit pH dependent absorption and fluorescence spectra with pKas near the normal physiological range. Unlike fluorescein, the dyes exhibit e... | 07/31/1990 |
| 4864039 | 3,3'(2'H,2H-Spirobibenzofuran compounds A novel 3,3'(2H,2'H)-spirobibenzofuran compound is disclosed. The spirobibenzofuran compound has a strong antioxidizing action and is thus useful as an antioxidant for dyes, synthetic polymer products such as rubbers, plastics and the like, and for petrol... | 09/05/1989 |
| 4835176 | Glycookadaic acid, preparation thereof and use thereof The present invention provides glycookadaic acid or salts thereof, processes for the preparation of such compounds, methods for treating and preventing cachexia and a side effect caused by TNF, and pharmaceutical compositions comprising such compounds as ... | 05/30/1989 |
| 4611070 | Spirodibenzopyrans Dye-forming components of the general formula ##STR1## where A is the radical of a fused benzo ring or 2,1-naphthalene ring, and either radical may be substituted by C1 -C4 -alkyl, C1 -C4 -alkoxy, nitro, ch... | 09/09/1986 |
| 4434295 | Anti-atherosclerotic 6,7-dihydro-7,7-disubstituted-khellin analogs The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1... | 02/28/1984 |
| 4415741 | Chroman-4-ones and process for preparing same Chroman-4-ones are prepared by reacting an o-hydroxyarylcarbonyl compound with a carbonyl compound in the presence of an amine. A typical reaction of o-hydroxy-acetophenone with cyclopentanone can be depicted as follows: ##STR1##... | 11/15/1983 |
| 4384094 | 3-Substituted- 7-dialkylamino-spiro(2H-1-benzopyran-2,3'-(3H)-naphtha(2,1-b)pyrans) Substituted spiro 2H-1-benzopyran-2,3'-(3H)-naphtho(2,1-b)pyrans particularly suitable for use as precursors to stable colored pyrylium salts are disclosed.... | 05/17/1983 |
| 4382134 | 3-Substituted-7-alkoxy-spiro(2H -1-benzopyran-2,3'-(3H)-naphtho(2,1-B)pyrans) Substituted spiropyrans particularly suitable for use as precursors to stable pyrylium salts are disclosed.... | 05/03/1983 |
| 4351957 | Process for preparing diaminodiphenyl-alkanes A process is described for the preparation of bis(aminophenyl)alkanes and bis(aminophenyl)cycloalkanes which comprises condensing a m-alkylphenol with an alkanone or cycloalkanone and heating the resulting condensation product with an at least stoichiomet... | 09/28/1982 |
| 4348508 | 3-Substituted-7-alkoxy-2,2'-Spirobi[2H-1-benzopyrans] Substituted Spirobi[2H-1-benzopyrans] particularly suitable for use as precursors to stable colored pyrylium salts are disclosed.... | 09/07/1982 |
| 4178381 | C-homoestratrienes C-homoestratrienes of the formula ##STR1## wherein ##STR2## R1 and R2 are the same or different, and each is hydrogen, acyl, alkyl, cycloalkyl or tetrahydropyranyl; and R3 is hydrogen, ethynyl or chloroethynyl; p... | 12/11/1979 |
| 4110348 | 7,7'-Diamino derivatives of 2,2'-spirodibenzopyranes Dye intermediates of the formula ##STR1## where R1 is hydrogen, alkyl of 1 to 12 carbon atoms, phenyl which is unsubstituted or substituted by alkyl of 1 to 4 carbon atoms, methoxy, ethoxy, chlorine or bromine, or phenylalkyl of 7 to 10 ca... | 08/29/1978 |
| 4057562 | Certain naphthofurans and method for their manufacture The invention relates to specific naphthofurans which are useful as cryochromic substances e.g. for measuring the temperature, pH value or radiation field.... | 11/08/1977 |
| 3985936 | Pressure-sensitive and/or heat sensitive copying or recording material The invention relates to copying and recording materials such as pressure-sensitive and/or heat-sensitive material, which contains as color former specific naphthofuranes.... | 10/12/1976 |
| 3974180 | Furanes, their manufacture and use The invention relates to specific naphthofuranes which are useful as cryochromic substances e.g. for measuring the temperature, pH value or radiation field.... | 08/10/1976 |
| 3971808 | Spirodipyrans and chromogenic materials for copying processes Spirodipyrans based on condensed pyrylium salts and 4-dialkylamino-2-hydroxybenzaldehydes, their manufacture and their use as chromogenic materials in pressure-sensitive recording materials, particularly copying papers.... | 07/27/1976 |
| 3957828 | 3-Aminoalkyl-1,3-dihydro-3-phenylspiro[isobenzofurans] Substituted 3-aminoalkyl-1,3-dihydro-3-phenylspiro[isobenzofurans] possessing tranquilizing properties, and process for the preparation thereof are described.... | 05/18/1976 |
