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| Number | Title | Issue Date |
| 7842825 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts... | 11/30/2010 |
| 7358030 | Process for producing ether compound The present invention provides the following process for production of an ether compound, which is useful for chemical amplification type resist compositions, synthetic intermediates of pharmaceuticals, paints, or the like, with less side reaction and in high yield.... | 04/15/2008 |
| 7288665 | Process for selective derivatization of taxanes Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(... | 10/30/2007 |
| 7211694 | Substituted 4-aminocyclohexanols Substituted 4-aminocyclohexanols, processes for their preparation, pharmaceutical compositions comprising these compounds and to the use of substituted 4-aminocyclohexanols in the preparation of pharmaceutical compositions for the treatment of various indications, e... | 05/01/2007 |
| 7202370 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and th... | 04/10/2007 |
| 7183436 | Substituted 4-aminocyclohexanols Substituted 4-aminocyclohexanols, methods of producing the same, pharmaceuticals containing these compounds, the use of substituted 4-aminocyclohexanols for producing pharmaceutical compositions for the treatment of various indications, in particular pain, and for r... | 02/27/2007 |
| 7169940 | Compounds and pharmaceutical compositions comprising same NST 400 compounds consisting of a unit for partial coordination of Ca2+ ions (CPCU). The NST 400 compounds are optionally conjugated to another pharmaceutically active compound. The compounds and conjugates can be used for affinity filters and for binding negative c... | 01/30/2007 |
| 7049448 | Process for the preparation of monoketals of 1,4-cyclohexanedione including 1, 4-cyclohexanedione mono-2,2-dimethyl trimethylene ketal There is provided a process for preparation of a monoketal compound of the structure that includes reacting 1,4-cyclohexanedione of the structure with a diol... | 05/23/2006 |
| 7026279 | Use of 3-(methoxymethyl)-2-pentylcyclopenta derivatives in perfume compositions 3-(methoxymethyl)-2-pentylcyclopent derivative compounds having the structure set forth below are disclosed: where: the dotted line represents a potential double bond; ... | 04/11/2006 |
| 7015363 | Process for producing ether compound The present invention provides the following process for producing and the like, which enables the production of an ether compound, which is useful for chemical amplification type resist compositions, synthetic intermediates of pharmaceuticals, paints, or the like, ... | 03/21/2006 |
| 6977270 | Tocotrienolquinone cyclization product with an anti-hypercholesterol effect A description is given of the use of at least one compound of the formula I where R1, R2, R3 and R4 independently of one another are H or C1-C6 | 12/20/2005 |
| 6962938 | Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms ... | 11/08/2005 |
| 6906205 | Spiro and dispiro 1,2,4-trioxolane antimalarials A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side ... | 06/14/2005 |
| 6887700 | Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into con... | 05/03/2005 |
| 6825230 | Spiro and dispiro 1,2,4-trixolane antimalarials A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side ... | 11/30/2004 |
| 6504037 | Process for preparing resorcinol derivatives The present invention relates to an improved process for preparing 4-substituted resorcinol derivatives, and intermediate compounds useful in the preparation of such resorcinol derivatives.... | 01/07/2003 |
| 6486199 | Spiro and dispiro 1,2,4-trioxolane antimalarials A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other ... | 11/26/2002 |
| 6469184 | Total synthesis of antitumor acylfulvenes The present invention provides a method of synthesizing compounds of formula (I): ##STR1## wherein R and R' are independently (C1 -C4)alkyl.... | 10/22/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6342459 | Photochromic naphthopyrans The present invention relates to photochromic 2H-naphtho[1,2-b]pyrans as well as their use in synthetic resins of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic naphthopyran compounds, for which... | 01/29/2002 |
| 6124479 | Process for the preparation of 1,3-dioxolane-4-methanols A process for preparing a 1,3-dioxolane-3-methanol (5) in a racemic form or an optically active form involves reacting with an alcohol in a base (i) a 3-halogeno-1,2-propanediol (1a) in which X is halogen atom, or (ii) a glycidol effecting a 3-alkoxy-1,2-... | 09/26/2000 |
| 5962704 | Production of amide derivatives and intermediate compounds therefor A method for producing an amide derivative of the formula XV! ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The p... | 10/05/1999 |
| 5616609 | Carcinostatic compound and production thereof Described are stelleramacrin A and stelleramacrin B represented by the following formulas (I) and (II), respectively: ##STR1## a process for the preparation thereof; and anticancer agents containing either of them as an active ingredient. Therapeutic... | 04/01/1997 |
| 5585490 | Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein: n is 0, 1 or 2, and R1, R2, X, Y and W are variables. These compounds are highly selective agonists, antag... | 12/17/1996 |
| 5576355 | Diamondoid derivatives for pharmaceutical use A method of inhibiting viruses in which a virus is contacted with diamondoid alcohol, ketone, ketone derivative, adamantyl amino acid, quaternary salt or combinations thereof which have antiviral properties. These diamondoid derivatives are shown to have ... | 11/19/1996 |
| 5493034 | Intermediate for pesticidal aminomethylheterocyclic compounds Fungicidally active compounds of the formula ##STR1## in which X represents oxygen or sulphur, R represents cycloalkyl, or represents optionally substituted aryl, or represents the radical ##STR2## R1 and R2 each independen... | 02/20/1996 |
| 5416225 | Total synthesis of taxol The present invention provides two basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as w... | 05/16/1995 |
| 5387593 | Piperazinyl-and piperidinyl-cyclohexanols Novel piperazinyl- and piperidinyl-cyclohexanols of the following formula are useful as anxiolytic agents and have other psychotropic properties ##STR1##... | 02/07/1995 |
| 5352678 | Antiischemic piperazinyl- and piperidinyl-cyclohexanes Certain piperazinyl- and piperidinyl-substituted cyclohexanes have anti-ischemic properties.... | 10/04/1994 |
| 5300705 | Process for the preparation of 1,25,26-trihydroxy-22-ene-cholecalciferol A process for preparing 1,25(R),26-trihydroxy-22E-ene-cholecalciferol and 1,25(S),26-trihydroxy-22E-ene-cholecalciferol.... | 04/05/1994 |
| 5286860 | Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands This invention encompasses compounds of the formula: ##STR1## and pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## represents: ##STR3## where n is 0, 1, or 2; R1 and R2 are hydrogen or straight o... | 02/15/1994 |
| 5283346 | Dioxolanes Alcohols of the formula ##STR1## wherein R1 and R2 are each independently methyl or ethyl or together signify pentamethylene, formed by the enzymatic hydrolysis of a corresponding (RS) alkanoic acid ester are intermediates for V... | 02/01/1994 |
| 5260472 | Efficient chemoenzymatic synthesis of D-myo-inositol 1,4,5-triphosphate, D-myo-inositol 1,3,4-triphosphate, and D-myo-inositol 1,3,4,5-tetraphosphate Multigram quantities of Ins(1,4,5) P3, Ins(1,3,4) P3, and Ins(1,3,4,5)P4 are prepared in their enantiomerically pure forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene myo-inositol. Also, a facile enzymatic pre... | 11/09/1993 |
| 5235057 | Aminodiol derivatives The invention relates to compounds of the formula ##STR1## in which R1 and R2 are identical or different and are hydrogen or aralkyl, R3 is alkyl, cycloalkyl or cycloalkylalkyl, R4 and R5 are ide... | 08/10/1993 |
| 5202444 | Optically isomeric inositol and process for making optically active compound Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hinderin... | 04/13/1993 |
| 5192798 | Lipophilic polyamines useful for treating hypercholesterolemia This invention relates to novel lipophilic polyamines of formula I, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto. Z1 --(CH2)n --Y1 --X1 --R1 I... | 03/09/1993 |
| 5110958 | Compounds, process and intermediates The claimed invention relates to intermediate compounds of the formula ##STR1## wherein R is hydrogen or methyl, R1 and R2 each, independently, is hydrogen, lower alkyl or aryl, or taken together are lower alkylene of from 3 to ... | 05/05/1992 |
| 5098932 | Cyclic ether derivatives The invention concerns a cyclic ether derivative of the formula I, ##STR1## wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; Ar2 is ... | 03/24/1992 |
| 5093490 | Process for optical resolution of bicyclo[3.3.0]octane-3,7-dione-2 carboxylic acid esters and their 7-monoketals The invention relates to a process for the production of (+)-bicyclo[3.3.0]octan-3-one-2 carboxylic acid steroid esters of formula I ##STR1## in which X means oxygen or the radicals --O--(CH2)n --O-- or --O--CH2 ... | 03/03/1992 |
| 5089629 | Fluorine-substituted cyclohexylcyclohexene derivative A compound represented by formula (I): ##STR1## wherein wherein R represents a straight chain alkyl group having from 1 to 9 carbon atoms; ##STR2## represents ##STR3## X represents a hydrogen atom or a fluorine atom; and ##STR4## ... | 02/18/1992 |
