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| Number | Title | Issue Date |
| 7718812 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivates The invention relates to a process for the conversion of group X in a 2-(6-substituted)-1,3-dioxane-4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylating agent, by using as a phase transfer c... | 05/18/2010 |
| 7407984 | Tetraoxaspriro anti-malarials The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not... | 08/05/2008 |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7371855 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 05/13/2008 |
| 7361771 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 04/22/2008 |
| 7342112 | Photochromic compounds Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other non-limiting embodiments relate to photochromic-dichroic compounds, which ... | 03/11/2008 |
| 7232915 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe... | 06/19/2007 |
| 7183422 | Oxonol compound and process for producing the compound A compound represented by the formula (I) defined herein and a compound represented by the formula (II) defined herein, and a process for producing the compound represented by the formula (I) which comprises reacting the compound represented by the formula (III) def... | 02/27/2007 |
| 7183408 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 02/27/2007 |
| 7071226 | Amino-functionalized 1,2,4-trioxanes useful as antimalarial agents and process for preparation thereof The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula 4 wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyph... | 07/04/2006 |
| 7049448 | Process for the preparation of monoketals of 1,4-cyclohexanedione including 1, 4-cyclohexanedione mono-2,2-dimethyl trimethylene ketal There is provided a process for preparation of a monoketal compound of the structure that includes reacting 1,4-cyclohexanedione of the structure with a diol... | 05/23/2006 |
| 7034165 | Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothil... | 04/25/2006 |
| 6933393 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 08/23/2005 |
| 6903225 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required... | 06/07/2005 |
| 6737438 | Substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof In the present invention relates to a novel series of antimalarial 1,2,4-trioxanes analogues of general formula 7, wherein R represents cycloalkyl groups selected from the groups consisting of cyclopentyl, cyclohexyl, cy... | 05/18/2004 |
| 6541473 | Resorcinol derivatives The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.... | 04/01/2003 |
| 6472544 | Process for the preparation of optically active 2-[6-hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as th... | 10/29/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6348608 | Catalytic asymmetric epoxidation A compound and method for producing an enantiomerically enriched epoxide from an olefin using a chiral ketone and an oxidizing agent is disclosed.... | 02/19/2002 |
| 6322727 | Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes A kit for detecting a first substance in a sample including a stabilized 1,2-dioxetane bearing an enzyme-labile substituent, which is destabilized and caused to decompose by contacting the 1,2-dioxetane with an enzyme under conditions which cause the enzy... | 11/27/2001 |
| 6200932 | Phenyl-substituted cyclic ketoenol The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) ##STR1## in which A, B, G, X, Y, Z and n are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and her... | 03/13/2001 |
| 6194589 | Production of amide derivatives and intermediate compounds therefor A method for producing an amide derivative of the formula [XV] ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The product... | 02/27/2001 |
| 6133461 | Process for producing amide derivatives and intermediates therefor A method for producing an amide derivative of the formula [XV] ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The pr... | 10/17/2000 |
| 6075155 | Radiation-curable cycloaliphatic epoxy compounds, uses thereof, and compositions containing them Disclosed are compounds of the formulas ##STR1## which are useful as monomers in photopolymerizable compositions. Also disclosed are methods of polymerizing these monomers, and polymers produced thereby.... | 06/13/2000 |
| 6025519 | Process for preparing cyclobutane-1,2-dicarboxylic esters Cyclobutane-1,2-dicarboxylic esters of the formula: ##STR1## in which R1 is a C1-8 -alkyl group, an optionally substituted mono- or bicyclic cycloaliphatic group having 3 to 10 ring carbon atoms, an optionally substituted aryl o... | 02/15/2000 |
| 5962704 | Production of amide derivatives and intermediate compounds therefor A method for producing an amide derivative of the formula XV! ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The p... | 10/05/1999 |
| 5864046 | 9-hydroxymethyl-7,12-dioxaspiro5,6!dodecane, 9-(2-hydroxyethyl)-7,11-dioxaspiro 5,5!undecane and a process for preparing said 9-(2-hydroxyethyl)-7,11-dioxaspiro 5,5!undecane Described herein is a process for the preparation of 9 (2-hydroxyethyl)-7, 11-dioxaspiro (5,5) undecane by reacting Cis-but-2-2ene-1,4 diol with cyclohexanone in the presence of a heterogeneous sulphonated nitro coal acid catalyst to obtain 7, 12-dioxaspi... | 01/26/1999 |
| 5847161 | 1, 2 chemiluminescent dioxetanes of improved performance A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stab... | 12/08/1998 |
| 5821374 | Process for the oxidation of alcohols A process for oxidizing primary and secondary alcohols to the corresponding aldehydes and ketones is disclosed. The oxidation is carried out by reacting the primary or secondary alcohol with an organic N-chloro compound oxidizing agent in the presence of ... | 10/13/1998 |
| 5785887 | Peroxygen bleach composition A peroxygen bleaching composition which comprises approximately by weight a mixture of about 1 to about 75% of an inorganic peroxygen bleaching compound; and about 1 to about 75% peroxygen ketalcycloalkanedione bleachant activator.... | 07/28/1998 |
| 5770773 | Process for the preparation of 5-amino-1,3-dioxanes A process for the preparation of 5-amino-1,3-dioxanes of formula (I), comprising the catalytic hydrogenation of the new oximes of formula (II) is described.... | 06/23/1998 |
| 5728848 | 9-hydroxymethyl-7,12 dioxaspiro5,6!dodecane, novel 9-(2-hydroxyethyl-7,11-dioxaspiro5,5!undecane and a process for preparing said 9-(2-hydroxyethyl-7,11 dioxaspiro 5,5!undecane This invention relates to novel compounds namely 9-hydroxymethyl-7,12-dioxaspiro5,6!dodecane and 9-(2-hydroxyethyl)-7, 11-dioxaspiro (5.5) undecane and a process for preparing 9-(2-hydroxyethyl)-7, 11-dioxaspiro (5.5) undecane which is employed as an ... | 03/17/1998 |
| 5716989 | Bicyclo3.3.0!octane derivatives, process for their production and their pharmaceutical use The invention relates to bicyclo3.3.0!octane compounds of formula I, ##STR1## wherein the variable are defined in this specification, as well as their enantiomers, and their salts with physiologically compatible bases. -, ଲ-, or ͌-Cyc... | 02/10/1998 |
| 5675005 | Process for preparing xanthine derivatives, in particular 1,3-dipropyl-8-(3-oxocyclopentyl)-xanthine This invention relates to a process for preparing xanthine derivatives of formula I: ##STR1## characterized in that a uracil derivative of formula A or B ##STR2## is dissolved in a suitable organic-aqueous solvent and cyclized in the presen... | 10/07/1997 |
| 5663372 | Process for the preparation of 5-amino-1,3-dioxanes Described herein is a process for the preparation of 5-amino-1,3-dioxanes of formula (I), wherein R and R1 have the meanings reported in the description, comprising the catalytic hydrogenation of the new oximes of formula (II).... | 09/02/1997 |
| 5648505 | Method for the preparation of a novel C-ring precursor for taxoids and novel intermediates The present invention relates to a process for the preparation of a compound of the formula (VIII) or (IX) useful as precursor for the C-ring in taxanes ##STR1## wherein R' is a C1 -C6 -alkyl. The invention further relates to ... | 07/15/1997 |
| 5635529 | Sulfonamidodioxepanes, methods of preparation, intermediates, salts and use thereof Novel O-substituted or O-unsubstituted 6-sulfonamido-1,3-dioxepane-5-ols having hypoglycemic activity are obtained from 6-amino-1,3-dioxepane-5-ol, tetrahydro-6H-[1,3]-dioxepino[5,6-d]oxazole, 5,6-epoxy-1,3-dioxepane or N-sulfonyl-tetrahydro-1H,4H-[1,3]-d... | 06/03/1997 |
| 5618943 | Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## the symbols have the meaning described in the specification have retinoid-like biological activity.... | 04/08/1997 |
| 5510488 | Process for trans-6- 2-(substituted-pyrrol-1-yl)alkyl!pyran-2-one inhibitors of cholesterol synthesis An improved process for the preparation of trans-6- 2-(substituted-pyrrole-1-yl)alkyl!pyran-2-ones by a novel synthesis is described where -metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and spe... | 04/23/1996 |
| 5481009 | Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods Methods of producing carboxylic acid ester derivatives of formulae (I) and (II), which are useful, for instance, as intermediates for producing an anti-hypercholesterolemic agent having an inhibitory effect on HMG-CoA Reductase: ##STR1## wherein... | 01/02/1996 |
