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| Number | Title | Issue Date |
| 7985866 | Vinyl ether compounds and polymerizable compositions Disclosed is an oxetane-containing vinyl ether compound including one or more aromatic or non-aromatic carbocycles and/or two or more vinyl ether structures, such as a compound of Formula: wherein Ring Z1 is non-... | 07/26/2011 |
| 7935835 | Substituted cycloalkene derivative A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by e... | 05/03/2011 |
| 7422908 | Chemiluminescent 1,2-dioxetanes A method of generating light through chemiluminescence involves providing a stable 1,2-dioxetane of the formula: Wherein (a) R1 and R2 are each, individually, a chemical reactive site or when fused tog... | 09/09/2008 |
| 7416898 | Chemiluminescent 1,2-dioxetanes A method of generating light through chemiluminescence involves providing a stable 1,2-dioxetane of the formula: Wherein (a) R1 and R2 are each, individually, a chemical reactive site or when fused tog... | 08/26/2008 |
| 7351739 | Bioactive compounds and methods of uses thereof In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds ... | 04/01/2008 |
| 7332523 | TNP-470 polymer conjugates and use thereof The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of ... | 02/19/2008 |
| 7300766 | Polymeric ammonium and or phosphonium salts having added π-electrons and higher molecular weight as enhancers for chemiluminescent systems A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker with either a trisubstituted amine or trisubstituted phosphine. A fluo... | 11/27/2007 |
| 7268111 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 09/11/2007 |
| 7223882 | Process for producing triterpene derivative A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 | 05/29/2007 |
| 7125527 | Methods of operating surface reactors and reactors employing such methods Methods of operating surface reactors, and such reactors, particularly spinning disc reactors require that a first reactant is fed to the reactor surface and forms a thin film on the surface. A second reactant is fed to the surface in the form of a second thin film ... | 10/24/2006 |
| 7115235 | Rotating surface of revolution reactor with temperature control mechanisms A reactor including a rotatable disc (3) having first (5, 19) and second (20, 30) surfaces. Reactant (15) is supplied to the first surface (5, 19) by way of a feed (4), the disc (3) is rotated at high speed, and the r... | 10/03/2006 |
| 7105482 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention. ... | 09/12/2006 |
| 7097995 | Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-PFormula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached an... | 08/29/2006 |
| 7084108 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 08/01/2006 |
| 7037890 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 05/02/2006 |
| 7014820 | Rotating surface of revolution reactor with feed and collection mechanisms A reactor including a rotatable disc (3) having a region (13) in an upper surface (5) thereof. Reactant (15) is supplied to the region (13) by way of a feed (4), the disc (3) is rotated at high speed, and the reactant... | 03/21/2006 |
| 6977063 | Rotating surface of revolution reactor with shearing mechanisms A reactor including a rotatable disc (3) having a surface (5) onto which reactant (15) is supplied by way of a feed (4). The disc (3) is rotated at high speed, and the reactant (15) spills over the surface (5) so as t... | 12/20/2005 |
| 6972113 | Rotating surface of revolution reactor with enhanced surface features A reactor including a rotatable disc (3) having a surface (5) onto which reactant (15) is supplied by way of a feed (4). The disc (3) is rotated at high speed, and the reactant (15) spills over the surface (5) so as t... | 12/06/2005 |
| 6949584 | TNP-470 species, polymer conjugates and use thereof The present invention relates to conjugates of water-soluble polymers and o-(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of... | 09/27/2005 |
| 6803382 | Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof The invention relates to novel 1-oxaspiro[2,5]octan-6-ol derivatives of general formula (I): and also to a method for preparing them, and to their use in pharmaceutical compositions for use in human or veterinary medic... | 10/12/2004 |
| 6756502 | Intermediate and processes for its preparation and conversion into a pharmacologically-active agent Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may... | 06/29/2004 |
| 6736998 | Indeno-fused photochromic naphthopyrans Described are novel reversible photochromic indenonaphthopyran compounds, examples of which are 2H-naphtho[1,2-b]pyrans characterized by having a substituted or unsubstituted indeno group fused at the 2,3 positions of the group to the 1 side of the 2H-naphthopyran. ... | 05/18/2004 |
| 6723859 | Chromene compound Novel chromene compounds having various substituents to exhibit a high color-developing sensitivity and a high density even when dispersed in a high-molecular matrix, and exhibiting a large fading rate, less color when deteriorated, and excellent light resistance in... | 04/20/2004 |
| 6686389 | 2,3-dihydrobenzofuran derivatives 2,3-Dihydrobenzofuran derivatives of general formula (1): ##STR1## wherein R1 represents a hydrogen atom or an acyl group; R2, R3 and R4 represent a hydrogen atom, a lower alkyl group or a lower alkenyl group; R... | 02/03/2004 |
| 6645996 | Physiologically active substances The present invention provides a novel bioactive substance having an antiangiogenic effect. The chemical compound represented by the formula (1) ##STR1## (wherein, R1 represents hydrogen atom, aldehyde group or a lower acyl group, R2... | 11/11/2003 |
| 6548477 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. Th... | 04/15/2003 |
| 6521764 | Process for the preparation of fumagillin The invention relates to a process for the preparation of Fumagillin by liberation from its salt characterized by reacting Fumagillin dicyclohexylamine salt with an organic acid in alcoholic medium. According to the process Fumagillin can be produced in h... | 02/18/2003 |
| 6482960 | Process for epoxidizing substituted cyclohexanones This invention relates to a method for preparing 1-oxaspiro[2,5]-carbonitriles from ketones using spinning disc reactor technology.... | 11/19/2002 |
| 6452022 | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids This invention relates to a method of preparing a compound type where at least one of R' or R" is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and wa... | 09/17/2002 |
| 6407268 | Substituted 4-benzoylpyrazoles 4-Benzoylpyrazoles of the formula I ##STR1## where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C1 -C6 -alkyl, C1 -C6 -haloalkyl, C1 -C6... | 06/18/2002 |
| 6355441 | Benzothiazole dioxetanes Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II: ##STR1##... | 03/12/2002 |
| 6337408 | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids This invention relates to a method of preparing a compound of the following type ##STR1## by treating a compound of formula (II) ##STR2## with lithium bromide, magnesium bromide and the like.... | 01/08/2002 |
| 6284899 | Chemiluminescent dialkyl-substituted 1,2-dioxetane compounds, methods of synthesis and use A chemiluminescent assay method and compositions are described which use a dialkyl-substituted dioxetane which is deprotected to trigger a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane compounds substituted on the dioxetane ring with two nonsp... | 09/04/2001 |
| 6225478 | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient Novel iridoid derivatives represented by general formula (I): ##STR1## and a vascularization inhibitor having for its active ingredient said derivative are disclosed. This vascularization inhibitor has remarkable vascularization inhibitory effects unaccom... | 05/01/2001 |
| 6139781 | Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescen... | 10/31/2000 |
| 6140495 | Chemiluminescent 1,2-dioxetanes Spiroadamantyl dioxetanes bearing an alkoxy substituent, and an aromatic substituent of phenyl or naphthyl on the dioxetane ring can be activated to chemiluminesce if the aromatic substituent bears a moiety designated OX, wherein the X is cleaved by an en... | 10/31/2000 |
| 6133459 | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c... | 10/17/2000 |
| 6124478 | Methods of using 1,2-dioxetanes and kits therefore Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a comp... | 09/26/2000 |
| 6063812 | Fumagillol derivatives and processes for preparing the same Compounds useful as angiogenesis inhibiting agents and processes for their preparation are disclosed. In one embodiment, the compounds of the invention are represented by Formula 1: ##STR1## Also disclosed is a pharmaceutical composition for inhibiti... | 05/16/2000 |
| 6040461 | Synthesis of 3-epi vitamin D3 metabolites and analogs The invention relates to a process for the preparation of vitamin D3 compounds of formula I. ##STR1## Wherein A is a single or a double bond; B is a single, cis-double, trans double or a triple bond; R1 and R2 are ind... | 03/21/2000 |
