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| Number | Title | Issue Date |
| 7026351 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods o... | 04/11/2006 |
| 6838128 | High polarization dopants for ferroelectric liquid crystal compositions The invention relates to chiral nonracemic liquid crystal compounds which are useful as components in liquid crystal compositions to impart high polarization to the mixture. The materials of this invention can be combined with liquid crystal host materials to impart... | 01/04/2005 |
| 6828276 | Herbicidally active benzoylcyclohexanediones There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radic... | 12/07/2004 |
| 6489492 | Chiral derivatives of Garcinia acid bearing lactone ring moiety and process for preparing the same The present invention relates to a novel chiral derivative of Garcinia acid bearing lactone ring moiety of formula I, ##STR1## wherein: R1 =R3 =alkali salt of carboxyl acid, or acid chloride or lower esters or part of N-substituted c... | 12/03/2002 |
| 6486196 | Anticancer compounds: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives ... | 11/26/2002 |
| 6395724 | Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ... | 05/28/2002 |
| 6388101 | Chemical-sensitization photoresist composition Proposed is a chemical-sensitization positive-working photoresist composition for photolithographic patterning in the manufacture of semiconductor devices having high transparency even to ultraviolet light of very short wavelength such as ArF excimer lase... | 05/14/2002 |
| 6313321 | Process for preparing ଲ-hydroxy-γ-butyrolactones and ଲ-(meth)acryloyloxy-γ-butrolactones The present invention provides a process for preparing ଲ-hydroxy-γ-butyrolactone or ଲ-methyl-ଲ-hydroxy-γ-butyrolactone represented by the formula (1): ##STR1## wherein R1 is hydrogen or methyl, which entails a) cyanatin... | 11/06/2001 |
| 6271180 | Substituted phenyl keto enols as pesticides and herbicides The present invention relates to novel compounds of the formula (I) ##STR1## in which Het represents one of the groups ##STR2## in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and... | 08/07/2001 |
| 6225288 | Gamma-ketoacid dipeptides as inhibitors of caspase-3 Compounds represented by formula I: ##STR1## as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, whic... | 05/01/2001 |
| 6166070 | Kodaistatins A, B, C and D, a process for their production and their use Kodaistatins A and B, compounds of the molecular formula C35 H34 O11, and Kodaistatins C and D, compounds of the molecular formula C35 H34 O12, have antidiabetic activity.... | 12/26/2000 |
| 6147228 | Convenient method for the large scale isolation of garcinia acid A process for the isolation of Garcinia acid from the fresh or dried rinds of the fruits of Garcinia indica, Garcinia cambogia and/or Garcinia atroviridis.... | 11/14/2000 |
| 6100292 | Ketone derivatives and their medical applications This invention relates to ketones represented by the following formula ##STR1## and to drugs in which such a ketone or pharmacologically acceptable salt thereof is an effective component. The ketones of the present invention encourage the production of pl... | 08/08/2000 |
| 6060046 | Antifouling compositions An antifouling composition that comprises an effective amount of a furanone of the structure shown and a suitable carrier therefor. In the figure, substituents R1, R2 and R3 are each a hydrogen atom, a hydroxyl group, an a... | 05/09/2000 |
| 6017951 | Butenolide endothelin antagonists Novel nonpeptides characterized as having a carbamic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds are useful in treating elevated lev... | 01/25/2000 |
| 5998408 | Triterpene derivatives with immunosuppressant activity The compounds of Formula I ##STR1## are useful as immunosuppressive agents.... | 12/07/1999 |
| 5922759 | Butenolide endothelin antagonists Novel nonpeptides characterized as having a carbarimic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds as useful in treating elevated le... | 07/13/1999 |
| 5905090 | Analogues of the active metabolite of leflunomide Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.... | 05/18/1999 |
| 5869524 | Indene inhibitors of COX-2 This invention provides compounds of formula 1 having the structure ##STR1## wherein: R1 is hydrogen, halogen, alkyl, alkoxy, fluoroalkoxy, trifluoromethyl, alkylthio, or SCF3 R2 and R3 are each independently, h... | 02/09/1999 |
| 5849217 | Optically active compound, liquid crystal composition containing the same, liquid crystal device using the same, liquid crystal apparatus and display method An optically active compound represented by the formula R1 --A1 --A2 --X1 --A3 --(CH2)p --L--A4 --R2, in which R1 is F, CN or straight chain, branched... | 12/15/1998 |
| 5747505 | Heterocyclic aryl-, alkyl- and cycloalkylacetamides The heterocyclic aryl-, alkyl- and cycloalklacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compoun... | 05/05/1998 |
| 5714484 | -(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a ... | 02/03/1998 |
| 5691373 | Nonpeptide endothelin antagonists I Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myoc... | 11/25/1997 |
| 5691374 | Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of ... | 11/25/1997 |
| 5610122 | 3-aryl-4-hydroxy-delta3-dihydrofuranone derivatives The present invention relates to a new 3-aryl-4-hydroxy-Ɗ3 -dihydrofuranone derivatives of the general formula (I) ##STR1## in which the radicals A, B, G, X, Y, Z and n have the meaning given in the description, to a plurality of processe... | 03/11/1997 |
| 5596124 | Method for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted)benzene compounds There is provided a method for safening herbicides in cereal crop plants by using 5-aryloxy-1,2 -(disubstituted)benzene compounds of formula I ##STR1## Further provided are compositions comprising a 5-aryloxy-1,2-(disubstituted)benzene compound of fo... | 01/21/1997 |
| 5565430 | Azaaspartic acid analogs as interleukin-1ଲ converting enzyme inhibitors Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, -substituted acetamides a ##STR1## wherein: R2 =H or alkyl; R3 =halo, O(CO)0-1 aryl, OPOR4 | 10/15/1996 |
| 5508302 | Phospholipase A2 inhibitors There are disclosed compounds of the formula: ##STR1## wherein R1 is ##STR2## X is O, or S; Y is O or NOR2 ; R2 is alkyl, alkenyl, phenyl, --CH2 CO2 R3, --CH2 Ph, --CH | 04/16/1996 |
| 5468774 | Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A.sub . There are disclosed compounds of the formula: ##STR1## wherein X is O; R1 and R2 are each, independently, hydrogen, C1 -C10 alkyl, C3 -C20 cycloalkyl, phenylloweralkyl, or substituted ... | 11/21/1995 |
| 5462939 | Peptidic ketones as interleukin-1ଲ-converting enzyme inhibitors Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R1 is (CR5 R6)n, (CR5 R6)n -aryl, (CR5 R6) | 10/31/1995 |
| 5428058 | Phospholipase A2 inhibitors There are disclosed compounds of the formula: ##STR1## wherein R1 is hydrogen, alkyl, cycloalkyl, arylalkyl, --(CH2)r CH.dbd.CH2, --(CH2)s OY, --(CH2)t CH(OZ)CH | 06/27/1995 |
| 5366993 | Tetronic, thiotetronic and tetramic acid derivatives as phospholipase A.sub . There are disclosed compounds of the formula: ##STR1## wherein X is O, S or NR; R is hydrogen or lower alkyl; R1 and R2 are each, independently, hydrogen, C1 -C10 alkyl, C3 -C20 cycloalkyl,... | 11/22/1994 |
| 5362752 | Chemical compounds New cholesterol lowering compounds are formed from the photochemical treatment of zaragozic acid A.... | 11/08/1994 |
| 5328916 | Heterocyclic compounds useful for inhibition of renin New heterocyclic compounds of the formula X--W--CR1 R2 --CO--Y--NR3 --CHR4 --CR5 --CH2 --(CR6 R7)r --Z--Het I in which R1 to R7 | 07/12/1994 |
| 5298633 | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: ##STR1##... | 03/29/1994 |
| 5258400 | Anti-inflammatory furanone compounds New furanone compounds have anti-inflammatory, immunosuppresive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis. A compound of the invention is 4-[3,6-dihydro-6-hydroxy-5-(3-phenylpropyl)-2H-pyran-2-y... | 11/02/1993 |
| 5256689 | Cholesterol lowering compounds Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents and as inhibitors of squalene synthase.... | 10/26/1993 |
| 5219884 | Immunosuppressant The present invention relates to an immunosuppressive agent which comprises at least one compound selected from the compounds of formula ##STR1## wherein R represents a hydrogen atom or an acyl, Y represents carbonyl or hydroxymethylene and represe... | 06/15/1993 |
| 5202350 | Furanone anti-inflammatory agents New compounds (3-alkyl-5-hydroxy-3,4-dihydrofuran-2-ones) of the following general structure: ##STR1## wherein R is an alkyl group or a phenylalkyl group with the alkyl moiety containing at least 6 carbon atoms, are disclosed as useful in inhibiting ... | 04/13/1993 |
| 5183906 | 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5H)-furanones as anti-inflammatory agents Novel anti-inflammatory furanone compounds have the following formula ##STR1## where R1 independently is H, phenyl, C1 -C6 alkyl substituted phenyl, halogen substituted phenyl, or alkyl of 1 to 6 carbons and n is an i... | 02/02/1993 |
