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| Number | Title | Issue Date |
| 8008512 | Pyridazine compound and use thereof A pyridazine compound represented by formula (1): has an excellent plant disease controlling effect. ... | 08/30/2011 |
| 7902383 | Production method of heterocyclic mercapto compound A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available startin... | 03/08/2011 |
| 7834200 | Processes and intermediates The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof. ... | 11/16/2010 |
| 7432381 | 1,3-oxathiolane-2-thione compounds The present invention relates to 1,3-oxathiolane-2-thione compounds of the general formula (I): wherein R1 and R2 are the same or different, each of which denotes a straight-chain or branched alkoxy re... | 10/07/2008 |
| 7414145 | Method of enantioselective nucleophilic addition reaction of enamide to carbonyl group and synthesis method of optically active α-hydroxy-γ-keto acid ester and hydroxydiketone A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active α-hydroxy-γ-keto acid ester, an optically active α-hydroxy-γ-amino acid ester, hydroxydiketone compounds, etc. being useful a... | 08/19/2008 |
| 7378535 | Production of furanones The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl c... | 05/27/2008 |
| 7371855 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 05/13/2008 |
| 7361771 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 04/22/2008 |
| 7235647 | Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically accept... | 06/26/2007 |
| 7232638 | Resist composition and patterning process Chemically amplified positive resist compositions comprising a polymer obtained by copolymerizing a silicon-containing monomer with a polar monomer having a value of LogP or cLogP of up to 0.6 and optionally hydroxystyrene, a photoacid generator and an organic solve... | 06/19/2007 |
| 7227029 | Method for the continuous production of N-methyl-2-pyrrolidone (NMP) Process for the continuous preparation of N-methyl-2-pyrrolidone (NMP) by reacting gamma-butyrolactone (GBL) with monomethylamine (MMA) in the liquid phase, wherein GBL and MMA are used in a molar ratio of from 1:1.08 to 1:2 and the reaction is carried out at from 3... | 06/05/2007 |
| 7214641 | Catalyst and hydrogenation of carbonyl compounds in the liquid phase using the catalyst The present invention provides a process for hydrogenating carbonyl compounds, in particular C4-dicarboxylic acids to mixtures of tetrahydrofuran and gamma-butyrolactone, over supported rhenium catalysts, wherein rhenium and at least one further metal of ... | 05/08/2007 |
| 7183408 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 02/27/2007 |
| 7183423 | Process for the preparation of organic compounds with imide catalysts (A) A compound capable of forming a stable radical and selected from (A1) oxygen-atom-containing compounds each having a carbon-hydrogen bond at the adjacent position to an oxygen atom, (A2) carbonyl-group-containing compounds, and (A3) compounds each having a hydro... | 02/27/2007 |
| 7109357 | Process and intermediates for making substituted aspartic acid acetals Disclosed herein is a method for making compounds that are useful as caspase inhibitor prodrugs of formula I: wherein R1 is an optionally substituted group selected from an aliphatic group, aralkyl group, he... | 09/19/2006 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7064220 | Production of furanones The present invention relates to the side chain functionalization of fimbrolides (halogenated 3-alkyl-5-methylene-2(5H)-furanones) and their synthetic analogues, that yields fimbrolides substituted with a halogen, an oxygen or a nitrogen functionality in the alkyl c... | 06/20/2006 |
| 7038064 | Process for producing hydroxylactones A process of the present invention produces a hydroxylactone by subjecting an unsaturated carboxylic acid having a double bond not conjugated to a carboxyl group or an ester thereof to (i) a reaction with hydrogen peroxide in the presence of a metallic compound cont... | 05/02/2006 |
| 6960573 | Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following for... | 11/01/2005 |
| 6933393 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 08/23/2005 |
| 6897324 | Process for the preparation of 11-oxaprostaglandins and intermediates therein For the preparation of an 11-oxaprostaglandin such as [2R,(1E,3R),3S,(4Z),4R)]-7-{tetrahydro-2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-4-hydroxy-3-furanyl}-4-heptenoic acid and its ester derivatives, a novel process uses a novel enantiomerically enriched compound ... | 05/24/2005 |
| 6838128 | High polarization dopants for ferroelectric liquid crystal compositions The invention relates to chiral nonracemic liquid crystal compounds which are useful as components in liquid crystal compositions to impart high polarization to the mixture. The materials of this invention can be combined with liquid crystal host materials to impart... | 01/04/2005 |
| 6835747 | Ft-0554a substances and process for the preparation thereof The present invention relates to obtain novel FT-0554A substance useful for infectious disease of parasite, especially helminth and more particularly relates to the novel FT-0554A substance represented by the following formula [I] | 12/28/2004 |
| 6812368 | Diastereoselective hydrogenation of 1,3-hydroxyketones The invention relates to a novel process of diastereoselective hydrogenation of 1,3-hydroxyketones of formula (I) wherein R, R′ and R″ are as defined in claim 1 which is carried out in a solvent in the prese... | 11/02/2004 |
| 6756013 | Compositions of iodonium compounds and methods and uses thereof The present invention provides a composition having biological activity. The composition includes from about 10 ppm to about 5000 parts iodonium salt. The composition also includes from about 100 ppm to about 300,000 ppm of a compound to act as a carrier of the iodo... | 06/29/2004 |
| 6737460 | Vinyl monomers having polyenic side chains derived from highly unsaturated fatty acids and derivatives thereof, and polymers of said monomers Vinyl monomers having polyenic side chains derived from highly unsaturated fatty acids represented by the general formula: R1COOH wherein R1 is a C19-24 hydrocarbon having 5 or 6 unsaturated bonds, and the derivatives thereof. Vinyl ... | 05/18/2004 |
| 6713639 | Process for preparing enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone The present invention relates to a process for the in situ preparation of optically pure (S)-3,4-dihydroxybutyric acid derivatives represented by the Formula [2] and more particularly, to a process which enables preparing optically pure (S)-3-hydroxy-γ-butyrolacton... | 03/30/2004 |
| 6713290 | Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone The present invention relates to a process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone expressed by the following Formula 1 and more particularly, to a process that enables preparing optically pure (S)-3-hydroxy-γ-butyrolactone economically in large... | 03/30/2004 |
| 6703515 | Chiral derivatives of Hibiscus acid bearing lactone ring moiety, process for preparing the same and a convenient method for the large-scale isolation of Hibiscus acid The present invention relates to a novel chiral compound of Hibiscus acid bearing lactone moiety of formula I, ##STR1## Wherein: R1.dbd.R.sub.2.dbd.alkali salt of carboxylic acid or acid chloride or lower esters or the N-substituted cyclic ... | 03/09/2004 |
| 6680389 | Ester compounds Acrylic esters containing fluorine at -position and having a lactone ring introduced into the ester side chain thereof are novel. Polymers obtained from the acrylic esters have a high transparency to VUV and good adhesion to substrates and are used... | 01/20/2004 |
| 6667330 | Furanone derivatives Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial i... | 12/23/2003 |
| 6642394 | Process for producing (meth)acrylic anhydride and process for producing (meth)acrylic ester (Meth)acrylic acid is reacted with a fatty acid anhydride and the resultant reaction mixture is neutralized and washed with an aqueous alkaline solution having a pH of 7.5 to 13.5. Thus, high-purity (meth)acrylic anhydride can be industrially advantageous... | 11/04/2003 |
| 6608214 | Process for producing optically active γ-butyrolactone This invention provides a novel process for producing optically active 3-hydroxy-γ-butyrolactone in a short step, which is superior economically and in efficiency and industrially suitable by using a starting material which is inexpensive and easily avai... | 08/19/2003 |
| 6593478 | Stereospecific hydrolysis of optically active esters A new, more efficient and highly stereospecific process is described for the preparation of compounds with general formula (R)-(I) and of absolute configuration (R), where the groups M, W, Q and Q1 are as defined in the description, starting fr... | 07/15/2003 |
| 6576632 | Biaryl compounds useful as anticancer agents The present invention relates to compounds of formula I ##STR1## and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b,... | 06/10/2003 |
| 6541646 | Method of preparing COX-2 inhibitors The invention relates to a method for producing compounds of general formula (I) wherein R1 is selected from the following groups: (a) OR5 and (b) mono-, di-, or tri-substituted phenyl; and R2 represents a group (C1 | 04/01/2003 |
| 6500963 | Process for preparing optically active dihydropyrones The invention relates to a new process for preparing optically active dihydropyrones, new intermediate products which may be obtained by this synthesis, and their use as starting compounds in the preparation of pharmaceutically active compounds.... | 12/31/2002 |
| 6486196 | Anticancer compounds: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives ... | 11/26/2002 |
| 6429319 | Continuous process for the production of optically pure (S)-beta-hydroxy-gamma-butyrolactone Disclosed is a process for the production of optically pure (S)-beta-hydroxy-gamma-butyrolactone through the hydrogenation of substituted carboxylic acid derivatives. A solution containing 1 to 50% by weight of a substituted carboxylic acid derivative is ... | 08/06/2002 |
| 6417377 | Process for preparing enantiomer-enriched amino- and hydroxyfuranones A process for the preparation of enantiomer-enriched aminofuranones and hydroxyfuranones in which an enantiomer-enriched cyanohydrin is acylated by an acylating agent, then cyclized at 40 to 90° C. in the presence of zinc or a zinc compound to the corres... | 07/09/2002 |
