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| Number | Title | Issue Date |
| 8124795 | Process for modifying drug crystal formation A process for modifying the crystal habit of acicular drug substances, crystals obtained by such a process, and particular crystal forms or modifications of mycophenolic acid or mycophenolate sodium are provided, as well as pharmaceutical compositions comprising the... | 02/28/2012 |
| 8008511 | Process for modifying drug crystal formation A process for modifying the crystal habit of acicular drug substances, crystals obtained by such a process, and particular crystal forms or modifications of mycophenolic acid or mycophenolate sodium are provided, as well as pharmaceutical compositions comprising the... | 08/30/2011 |
| 7216041 | Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecul... | 05/08/2007 |
| 7152611 | Coated multifilament dental devices overcoated with imbedded particulate Disclosed are coated multifilament dental devices overcoated with biofilm-responsive, imbedded, particulate abrasives. ... | 12/26/2006 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7019133 | Process for making mycophenolate mofetil by transesterification A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenol... | 03/28/2006 |
| 6967214 | Inhibitors of IMPDH enzyme The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suite... | 11/22/2005 |
| 6919335 | Heterocycles that are inhibitors of IMPDH enzyme Compounds of the formula wherein X1 is C(O), —S(O)—, or —S(O)2—; X2 is CR3 or N; X3 is —NH—, —O—, or —S—; X4 is ... | 07/19/2005 |
| 6872839 | Benzofuran-2-one Benzofuran-2-ones, compositions comprising benzofuranones, processes for preparing them, and their use as colorants for high or low molecular mass organic material. ... | 03/29/2005 |
| 6858743 | Method for the production of 2-coumarone and substituted 2-coumarones The invention relates to a method for the production of 2-coumarone or substituted 2-coumarones, whereby cyclohexanone or substituted cyclohexanone is reacted with a carboxyl-containing acylating agent a) to give methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetate or subst... | 02/22/2005 |
| 6710187 | Process to isolate dianhydrides A process to isolate dianhydride from an exchange reaction comprises extracting a bisimide/anhydride exchange reaction aqueous phase with an organic solution comprising an exchange catalyst at a first temperature and pressure to form an extracted aqueous phase compr... | 03/23/2004 |
| 6503942 | Ethers of O-Desmethyl venlafaxine This invention provides O--acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): ##STR1## wherein: the configuration at the steriogenic center (*) may be R, S, or RS (... | 01/07/2003 |
| 6310220 | Stabilizing polycarbonates This invention relates to compositions comprising a polycarbonate, polyester or polyketone which is subject to oxidative, thermal and/or light-induced degradation, or their mixtures and blends, and at least one benzofuran-2-one type compound, to the use t... | 10/30/2001 |
| 6204394 | Method for preparing oxy-diphthalic anhydrides Disclosed is a method for preparing oxy-diphthalic anhydrides, which comprises reacting a halo-phthalic anhydride represented by the formula (1): ##STR1## where Hal represents F, Cl, Br or I, with a carbonate salt selected from the group consisting o... | 03/20/2001 |
| 6143779 | Benzofuranone derivatives and a method for producing them The present invention provides new benzofuranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases. The present invention is a new benzofuranone derivative represente... | 11/07/2000 |
| 6020501 | Process for preparing phthalides The disclosure is a process for preparing a phthalide of the general formula I ##STR1## where R1, R2, R3 and R4 are each independently of the others hydrogen, C1 -C4 -alkyl or C1 | 02/01/2000 |
| 5892025 | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that referentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (-)-2-hydroxy... | 04/06/1999 |
| 5693829 | Benzofuran-2-ones as stabilizers The invention relates to compounds of formula I ##STR1## wherein the general symbols are as defined in claim 1, as stabilizers for protecting organic materials against thermal, oxidative or light-induced degradation.... | 12/02/1997 |
| 5538969 | 4-amino derivatives of 5-substituted mycophenolic acid The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.... | 07/23/1996 |
| 5516920 | 3-arylbenzofuranones The invention described novel compounds of formula ##STR1## wherein the general symbols are as defined in claim 1, as stabilisers for protecting organic materials, in particular polymers and lubricants, against thermal, oxidative or light-induced deg... | 05/14/1996 |
| 5512568 | Method of using 4-amino derivatives of 5-substituted mycophenolic acid The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.... | 04/30/1996 |
| 5506262 | Cholesterol lowering compounds Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthetase, inhibitors of fungal growth, inhibitors of farnesyl-protein trans... | 04/09/1996 |
| 5502216 | Lignan analogues, methods of preparation thereof and anti-hyperlipemic agents An anti-hyperlipemic agent which has a potent activity of reducing LDL and VLDL cholesterols, which are thought to be a risk factor for arteriosclerosis among total blood cholesterols, and which is excellent in the antioxidant activity on LDL, is provided... | 03/26/1996 |
| 5493030 | 5-substituted derivatives of mycophenolic acid The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferati... | 02/20/1996 |
| 5488117 | 3-(acyloxyphenyl)benzofuran-2-one stabilisers Compounds of the formula (1) ##STR1## in which R2, R3, R4 and R5 independently of one another, are hydrogen, C1 -C25 alkyl, C7 -C9 phenylalkyl, unsubstituted or C... | 01/30/1996 |
| 5441953 | 4- amino derivatives of mycophenolic acid The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.... | 08/15/1995 |
| 5380879 | Derivatives of mycophenolic acid The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.... | 01/10/1995 |
| 5326783 | Cholesterol lowering compounds This invention is directed to compounds of formula (I) which are novel C3- or C5-acyl sulfonamide, carboxamic acid or tetrazolyl analogs of the Zaragozic acids. These compounds inhibit the enzyme squalene synthase and are useful as cholesterol lowering ag... | 07/05/1994 |
| 5296614 | Preparation of phthalides A process for the preparation of phthalides of the formula I ##STR1## where R1, R2, R3 and R4 independently of one another, are hydrogen, C1 - to C4 -alkyl or C1 - to C4 | 03/22/1994 |
| 5258401 | Cholesterol lowering compounds Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthase, inhibitors of fungal growth, inhibitors of farnesyl-protein transfe... | 11/02/1993 |
| 5256689 | Cholesterol lowering compounds Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents and as inhibitors of squalene synthase.... | 10/26/1993 |
| 5183907 | Process for preparing diphenyl ethers Diphenyl ether derivatives of formula II ##STR1## wherein R1 represents a hydrogen or halogen atom or an alkyl or haloalkyl group, R2 and R3, which may be the same or different, each independently represents a hydroge... | 02/02/1993 |
| 5175312 | 3-phenylbenzofuran-2-ones Novel compounds of the formula I ##STR1## in which R1 is C13 -C30 alkyl, R2 is hydrogen, C1 -C10 alkyl, C5 -C12 cycloalkyl, C5 -C7 cycloalkyl ... | 12/29/1992 |
| 5162550 | Bisphthalide lactones, their preparation and the use thereof in recording materials Bisphthalide lactones of formula ##STR1## wherein R1, R2, R3 and R4 are each independently of one another hydrogen, alkyl of at most 12 carbon atoms which is unsubstituted or substituted by halogen, hydroxy... | 11/10/1992 |
| 5100456 | Herbicidal metabolites of phomopsis convoluvulus for the effective control of field bindweed The invention relates to the isolation, characterization and application of a bioherbicide composition characterized by its phytotoxcity towards the agricultural pest Convolvulus arvensis (field bindweed) and the aquatic weed Lemna paucicostata. The compo... | 03/31/1992 |
| 5097044 | Pyran-containing phthalides Pyran-containing phthalides of the formula ##STR1## in which R is hydrogen, alkyl which has not more than 12 carbon atoms and is unsubstituted or substituted by halogen, cyano, hydroxyl or lower alkoxy, or is cycloalkyl, phenalkyl or phenyl each of w... | 03/17/1992 |
| 5077416 | Benzodifuranone compounds useful for dyeing or printing hydrophobic fiber materials and process for their production A heterocyclic compound of the formula, ##STR1## wherein A and B are each hydrogen, alkyl or alkoxy, Y is hydrogen, alkyl, alkoxy or --O--R2 --X--R1, or Y and B are taken together with each other to form methylenedioxy, R1 | 12/31/1991 |
| 5004813 | Chromogenic phthalides and azaphthalides Chromogenic phthalides and azaphthalides of the formula ##STR1## in which V1 and V2 are each, independently of the other, hydrogen, halogen, lower alkyl, lower alkoxy, (lower alkoxy)carbonyl or --NR1 R2, at... | 04/02/1991 |
| 4876357 | Chromogenic phthalides and azaphthalides Chromogenic phthalides and azaphthalides of the formula ##STR1## in which V1 and V2 are each, independently of the other, hydrogen, halogen, lower alkyl, lower alkoxy, (lower alkoxy)carbonyl or --NR1 R2, at... | 10/24/1989 |
| 4868301 | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains Oxophthalazinyl acetic acids having aldose reductase inhibitory properties of the formula ##STR1## wherein Z is hydrogen or methyl, U is S, CH2 or a covalent bond, and R1, R3, R4, R5 and R6 | 09/19/1989 |
