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| Number | Title | Issue Date |
| 8309744 | Prostaglandin synthesis and intermediates for use therein Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: wherein R represents an aryl group such ... | 11/13/2012 |
| 8258319 | Exo- and diastereo- selective synthesis of himbacine analogs This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be... | 09/04/2012 |
| 8153826 | Process for production of (±)-3a,6,6,9a-Tetramethyldecahydronaphtho[2,1-b]Furan-2(1H)-one The present invention relates to industrially useful production processes in which (±)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-ones and further (±)-3a,6,6,9a-tetramethyldo decahydronaphtho[2,1-b]furans are produced from raw materials which are read... | 04/10/2012 |
| 7928252 | Prostaglandin synthesis and intermediates for use therein Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: wherein R represents an aryl group such ... | 04/19/2011 |
| 7737286 | α-Hydroxy-benzeneacetic acid derivatives, and compounds having two 5-membered latone rings fused to central cyclohexa-1,4-diene nucleus based upon the same, and uses of the compounds The present invention provides α-hydroxy benzeneacetic acid derivatives of the formula as defined in the specification which is a precursor indispensable for synthesis of compounds having two 5-membered lactone rings fused to central cyclohexa-1,4-diene nucleus, an... | 06/15/2010 |
| 7626045 | Synthesis of himbacine analogs The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improv... | 12/01/2009 |
| 7605275 | Exo- and diastereo- selective syntheses of himbacine analogs This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be... | 10/20/2009 |
| 7312242 | Use of parthenolide derivatives as antileukemic and cytotoxic agents Compounds of the formula having anti-tumor activity, wherein R1 and R2 are as described herein ... | 12/25/2007 |
| 7226625 | Identification of compositions, compositions, and methods of treatment of obesity and overweight conditions A method for the identification of a composition useful in the treatment of an overweight or obese person to reduce the person's body mass index is provided which comprises obtaining an extract of an ethnobotanical plant, and evaluating the activity of the extract i... | 06/05/2007 |
| 7214713 | Antraquinone compositions as anticancer compositions and nutrition supplements and methods of making and using them A food supplement having prophylactic and-cancer effects, wherein the supplement comprises 20 to 99.99% by weight of a product of biosynthesis by the productive microorganism Penicillium oxalicum var. Armeniaca CCM 8242, obtained by fermentation of a nutrient broth ... | 05/08/2007 |
| 7193041 | Method for purification of recombinant proteins Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2+ and a coordination number of 6. A method for syn... | 03/20/2007 |
| 7118604 | Non azo disperse dye mixtures The present invention refers to a dye mixture comprising an azo dye of the formula (I) and one or more dyes of the general formula (II) wherein ... | 10/10/2006 |
| 7090856 | Anti-fouling exopolysaccharides isolated from cultures of and An anti-fouling agent derived by culturing Vibrio alginolyticus in a suitable aqueous solution as well as a newly isolated strain of V. alginolyticus (DSM 15590) for producing the anti-fouting agent. The anti-fouling agent can be used as a component to... | 08/15/2006 |
| 7019152 | Process for the optical resolution of a precursor of sclareolide The present invention relates to the field of organic synthesis and more particularly to a new process for the optical resolution of a precursor of sclareolide. This process includes the reaction of [(1RS,2RS,4aSR,8aSR)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphtha... | 03/28/2006 |
| 6989446 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V wherein ... | 01/24/2006 |
| 6713435 | Method for producing optically active lactone compounds by using salen cobalt complexes having a cis-β structure A method for producing an optically active lactone compound by Baeyer-Villiger oxidation of a cyclic ketone compound with at least one kind of oxidants selected from the group consisting of hydrogen peroxide and urine-hydrogen peroxide adduct (UHP) using a cobalt(sa... | 03/30/2004 |
| 6576766 | Signal transduction inhibitors, compositions containing them This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p... | 06/10/2003 |
| 6509480 | Glucose and lipid lowering compounds Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: ##STR1## wherein the dotted line between carbons 5 and 6, the dot... | 01/21/2003 |
| 6492533 | Bismethine benzodifuranone derivative colorants Colorants comprising a chromophore having two methine moieties attached to a benzodifuranone backbone, wherein said moieties optionally have at least one poly(oxyalkylene) chain, preferably at least two such chains attached thereto are provided. Such colo... | 12/10/2002 |
| 6476238 | Purification method for obtaining high-purity PMDA A purification method for obtaining high-purity PMDA. The method controls temperatures of cyclone separators in a series to separate PMDA and other by-products of different sublimation temperatures. High-purity PMDA is collected in the first cyclone separ... | 11/05/2002 |
| 6462204 | Polycyclic dyes The present invention refers to a polycyclic dye of the formula (I) ##STR1## wherein each of R1, R2, R4 and R5, independently, is hydrogen, alkyl or alkoxy; R3 is hydrogen, alkyl, optionally substituted al... | 10/08/2002 |
| 6429203 | Farnesyl-protein transferase inhibitors Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described... | 08/06/2002 |
| 6417358 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim 1, with carbon monoxide in the ... | 07/09/2002 |
| 6392059 | Hydronaphtho[2,3-c]furan derivatives and process for the preparation thereof Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: ##STR1## wherein R1 | 05/21/2002 |
| 6387258 | Method of purifying statins from a fermentation broth A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Followin... | 05/14/2002 |
| 6326396 | Glucose and lipid lowering compounds Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: ##STR1## wherein the dotted line between carbons 5 and 6, the dot... | 12/04/2001 |
| 6262110 | Farnesyl-protein transferase inhibitors Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting fanesyl-protein transferase activity are also described.... | 07/17/2001 |
| 6255338 | Use of calcium intracellular store inactivators and formulations thereof as cell growth inhibitors The use of a calcium intracellular store inactivator for inhibiting cell growth is disclosed; for example, thapsigargin or a derivative may be used to inhibit intraocular lens cell growth. Formulations include an emulsion of the compound for coating an IO... | 07/03/2001 |
| 6255339 | Tetrahydronaphthofuranone derivatives and process for producing the same Compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof are disclosed. The compounds have progesterone receptor binding inhibitory activity and, hence, can be used as therapeutic and prophylactic agents for progest... | 07/03/2001 |
| 6218552 | 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dione A compound, 3-phenyl-7-[4-(tetrahydrofurfuryloxy)phenyl]-1,5-dioxa-s-indacene-2,6-dion e, which has a structure of crystals exhibiting the strongest peak at an angle of diffraction, 2θ, of 4.7°, among peaks appearing within the range of not smaller ... | 04/17/2001 |
| 6197767 | Arglabin compounds and therapeutic uses thereof The invention provides various derivatives of arglabin, a sesquiterpene lactone isolated from Artemisia glabella. These compounds are effective for suppressing tumor growth in mammals. A method of suppressing tumor growth in humans is also described.... | 03/06/2001 |
| 6071946 | Tricyclic urea compounds A compound selected from those of formula (I): ##STR1## in which A, Y, R1, R2 and R3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal aff... | 06/06/2000 |
| 6051565 | Farnesyl-protein transferase inhibitors Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described... | 04/18/2000 |
| 6020365 | Arglabin compounds and therapeutic uses thereof The invention provides various derivatives of arglabin, a sesquiterpene lactone isolated from Artemisia glabella. These compounds are effective for suppressing tumor growth in mammals. A method of suppressing tumor growth in humans is also described.... | 02/01/2000 |
| 6013811 | Preparation process of benzodifuranone dyes A process for the preparation of a polycyclic dye of Formula (1) which comprises steps: i) reaction of a compound of formula (2) with a compound of formula (3) or a derivative thereof to form an intermediate of formula (4) and ii) reaction of the intermed... | 01/11/2000 |
| 6011058 | Seco-cholestane derivatives and methods of making the same The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates to C5- and C8-substituted seco-cholestane derivatives. The ... | 01/04/2000 |
| 6001781 | Process for preparing condensation product of hydroxy-substituted aromatic compounds and glyoxylic reactants The present invention is directed to a process for preparing a condensation product of a glyoxylic reactant and a hydrocarbyl-substituted aromatic compound having at least one hydroxy functionality, which includes (a) providing the glyoxylic reactant in t... | 12/14/1999 |
| 5998461 | Tricyclic amide compounds This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.... | 12/07/1999 |
| 5965604 | Chrolactomycin compound The present invention relates to chrolactomycin compound represented by the following formula (I): ##STR1## or pharmaceutically acceptable salts thereof having antibacterial and antitumor activities.... | 10/12/1999 |
| 5962641 | Method for purification of recombinant proteins Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2+ and a coordination number of 6. A me... | 10/05/1999 |
