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| Number | Title | Issue Date |
| 7381744 | Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a vacuolar-type (H+)-ATPase. The composition of the present invention compri... | 06/03/2008 |
| 7317100 | Epothilone derivatives The present invention relates to C4-demethyl-epothilones or C4-bisnor-epothilones of Formula (I), their pharmaceutical use, pharmaceutical composition containing the same and methods for their preparation. ... | 01/08/2008 |
| 7115651 | Macrocycles and uses thereof The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and... | 10/03/2006 |
| 7109235 | Microtubule stabilizing compounds Laulimalide and epothilone derivatives useful as microtubule stabilizing agents, and in the treatment of cancers are disclosed. Methods of making the compounds and using the compounds as therapeutic agents in treating cancers also are disclosed. ... | 09/19/2006 |
| 7105268 | Polymer for photoresist and resin compositions therefor A polymeric compound for photoresist of the invention includes at least one monomer unit represented by following Formula (I): wherein R1, R2, R3, R4 and R5 ... | 09/12/2006 |
| 7094725 | Biphenyldiphosphine compounds The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R′ is alkyl or aryl; ... | 08/22/2006 |
| 7026352 | Physiologically active substances The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incuba... | 04/11/2006 |
| 6982280 | Epothilone derivatives, a method for the production thereof, and their use The present invention relates to epothilon derivatives, processes for their production and their use in the manufacture of medicaments and plant protection agents. ... | 01/03/2006 |
| 6946482 | Motilide compounds Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditi... | 09/20/2005 |
| 6936723 | Synthetic salicylihalamides, apicularens and derivatives thereof The present invention provides compounds having improved stability over that of natural benzolactones, and a process for synthesizing these compounds. These compounds exhibit anti-cancer activity and inhibit V-ATPase activity. ... | 08/30/2005 |
| 6872747 | Decalactones, method for making, and pharmaceuticals there from A novel class of decalactones with the general formula (I) and their stereoisomers is disclosed. A method for the synthesis of the decalactones of general formula (I) and the use of the decalactones in pharmaceutical compositions is also described. | 03/29/2005 |
| 6828340 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 12/07/2004 |
| 6815463 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ... | 11/09/2004 |
| 6765016 | Bicyclic ketolide derivatives The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical c... | 07/20/2004 |
| 6710073 | Drugs to improve synaptic transmission Peripherally administered analogs and derivatives of Brefeldin A are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal tissues. ... | 03/23/2004 |
| 6670389 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ##STR1##... | 12/30/2003 |
| 6635662 | Radicicol derivatives Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: ##STR1## wherein R1 and R2 are the same or different, and each represents h... | 10/21/2003 |
| 6617348 | Synthetic salicylihalamides, apicularens and derivatives thereof The present invention provides compounds having improved stability over that of natural benzolactones, and a process for synthesizing these compounds. These compounds exhibit anti-cancer activity and inhibit V-ATPase activity.... | 09/09/2003 |
| 6528489 | Mycotoxin derivatives as antimitotic agents The present invention provides a treatment for mammalian diseases characterized by aberrant cell proliferation. The treatment consists of administering therapeutically active dosages of antibiotic inhibitors such as efrapeptin oligopeptides or mycotoxin d... | 03/04/2003 |
| 6486330 | 4-oxatricyclo[4.3.1.1 3,8]undecan-5-one derivative and process for producing the same A 4-oxatricyclo[4.3.1.13,8 ]undecan-5-one derivative is shown by the following formula (1): ##STR1## wherein R is a hydrogen atom or a (meth)acryloyl group, and carbon atoms constituting a ring may have a substituent in addition to the substitu... | 11/26/2002 |
| 6369099 | Method of locking 1 -OH of vitamin D compounds in axial orientation A method of modifying or altering the structure of a 1-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1-hydroxyl in... | 04/09/2002 |
| 6362218 | Brefeldin A derivatives Cytotoxic Michael addition derivatives of brefeldin A are described. Oxidation of thiol addition products of brefeldin A provides the corresponding sulfoxides and sulfones. The sulfoxides exhibited more cytotoxic activity than the corresponding sulfides a... | 03/26/2002 |
| 6353019 | Macrocyclic lactones, compositions, and methods of use The present invention provides compound of the formula: ##STR1## wherein R1 and R2 are the same or different and are independently H, C1 -C6 straight-chain or branched saturated or unsaturated alkyl, aryl, R | 03/05/2002 |
| 6242469 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present inve... | 06/05/2001 |
| 6239168 | Radicicol derivatives Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: ##STR1## wherein R1 and R2 are the same or different, and each represents h... | 05/29/2001 |
| 6074838 | Zearalenone detoxification compositions and methods The present invention provides a bacterial microorganism having the ability to degrade or detoxify zearalenone or derivatives or analogs of zearalenone. The present invention also provides a method for the isolation and utilization of a zearalenone-degrad... | 06/13/2000 |
| 6025350 | C-4" substituted macrolide antibiotics This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infec... | 02/15/2000 |
| 5977165 | Radicicol derivatives The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R1 and R2 are the same or different and each represents hydrogen, al... | 11/02/1999 |
| 5786490 | Process for preparing compositions useful as intermediates for preparing lubricating oil and fuel additives A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.... | 07/28/1998 |
| 5710174 | Factor XIIIA inhibitor A compound that is useful for inhibiting FXIIIa catalysis of fibrin cross-linking, and related pharmaceutical compositions and methods, are disclosed. The compound and compositions may be advantageously used to enhance fibrinolysis and resolution of blood... | 01/20/1998 |
| 5696154 | Brefeldin A derivatives and their utility in the treatment of cancer Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R1 and R2 is H and the other of R1 and R2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or ... | 12/09/1997 |
| 5688924 | Derivatives of 12,13-Epoxy-tylosin and processes of manufacture thereof The invention relates to derivatives of 12,13-epoxy-tylosin, the novel seynthetic antibiotics from tylosin group and the methods of their preparation. According to this invention hydrogenation followed by oximation of 12,13-epoxy-tylosin derivatives yiel... | 11/18/1997 |
| 5593978 | Growth promoting composition for fish and method of using the same A method for promoting growth in fish comprising administering a low level dosage amount of zearalanol to fish. The zearalanol may be conveniently administered to the fish via a novel fish feed formulation comprising a conventional feed mixture supplement... | 01/14/1997 |
| 5523418 | Macrocyclic lactam prokinetic agents Macrocylic lactam compounds of formula (i) ##STR1## and pharmaceutically acceptable salts thereof, wherein A is selected from ##STR2## also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the inv... | 06/04/1996 |
| 5514662 | Use of amphotericin B derivatives as protease inhibitors The invention is directed toward the use of amphotericin B and derivatives thereof as inhibitors of serine-proteases and for applying these inhibitors for the production of medicinal products intended for the treatment of infection by the human immunodefi... | 05/07/1996 |
| 5444174 | 16-membered macrolide derivative having sustained antibacterial activity in plasma, synthesis intermediate thereof and process for producing the same 16-membered macrolide compounds wherein both of hydroxyl groups at the 3"- and 4"-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds... | 08/22/1995 |
| 5362752 | Chemical compounds New cholesterol lowering compounds are formed from the photochemical treatment of zaragozic acid A.... | 11/08/1994 |
| 5256689 | Cholesterol lowering compounds Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents and as inhibitors of squalene synthase.... | 10/26/1993 |
| 5210224 | Process for preparing lankacidin carbamate derivatives A process for preparing a lankacidine carbamate derivative of the formula ##STR1## or a salt thereof, by the reaction of a lankacidine 8-substituted carbonate with an amine, wherein R1 is a hydroxy group or an alkanoyloxy group; and R... | 05/11/1993 |
| 5210225 | Zeranol production A process for producing high purity -zeranol from a zeralenone containing surface fermentation product is described. One feature of the process entails fractional crystallization from an aqueous acetonitrile solvent of high purity -zeranol f... | 05/11/1993 |
