Famous Patents
3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7674921 | Internal 1,15-lactones of fluprostenol and related prostaglandin F analogs and their use in the treatment of glaucoma and intraocular hypertension Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topica... | 03/09/2010 |
| 7553979 | HSP90-inhibiting zearalanol compounds and methods of producing and using same Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are also described and claimed. | 06/30/2009 |
| 7381744 | Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a vacuolar-type (H+)-ATPase. The composition of the present invention compri... | 06/03/2008 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| RE39592 | Extended release growth promoting two component composition An extended release composition comprising a first composition comprising growth promoters and a second composition comprising growth promoters and a biodegradable polymer is described. A method of increasing weight gain in food animals utilizing the composition, a ... | 04/24/2007 |
| 7115651 | Macrocycles and uses thereof The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and... | 10/03/2006 |
| 7081474 | Drugs to improve synaptic transmission Peripherally administered Brefeldin A and its analogs and derivatives are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal issues. ... | 07/25/2006 |
| 7001531 | Sustained release coolant additive composition A coolant additive composition comprising a sustained release component and an additive component, the additive component is effective to provide at least one benefit to a coolant when released into the coolant, the sustained release component includes a polymeric m... | 02/21/2006 |
| 6815463 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ... | 11/09/2004 |
| 6713464 | Derivatives of 3,3-diphenylpropylamines The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodr... | 03/30/2004 |
| 6710073 | Drugs to improve synaptic transmission Peripherally administered analogs and derivatives of Brefeldin A are used to enhance learning and reverse memory dysfunction through induced long term potentiation in hippocampal tissues. ... | 03/23/2004 |
| 6670389 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ##STR1##... | 12/30/2003 |
| 6498153 | Extended release growth promoting two component composition An extended release composition comprising a first composition comprising growth promoters and a second composition comprising growth promoters and a biodegradable polymer is described. A method of increasing weight gain in food animals utilizing the comp... | 12/24/2002 |
| 6369099 | Method of locking 1 -OH of vitamin D compounds in axial orientation A method of modifying or altering the structure of a 1-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1-hydroxyl in... | 04/09/2002 |
| 5786490 | Process for preparing compositions useful as intermediates for preparing lubricating oil and fuel additives A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.... | 07/28/1998 |
| 5731293 | Esculetin derivatives, method for manufacture thereof, and pharmaceutical composition A compound of the formula (I): ##STR1## wherein R1 and R2 are, independently, --CON(R4)R5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R1 and R | 03/24/1998 |
| 5514662 | Use of amphotericin B derivatives as protease inhibitors The invention is directed toward the use of amphotericin B and derivatives thereof as inhibitors of serine-proteases and for applying these inhibitors for the production of medicinal products intended for the treatment of infection by the human immunodefi... | 05/07/1996 |
| 5185452 | Benzheterocyclyl sulphones The invention concerns novel, pharmaceutically useful, benzheterocyclyl sulphones of the formula I: ##STR1## in which ring A may bear optional halogeno, (1-4C)alkyl or fluoro(1-4C)alkyl substituents; X is oxygen, or a group of the formula --S(O)... | 02/09/1993 |
| 5089521 | 10-membered ring lactones, a process for the preparation thereof, and the use thereof New 10-membered ring lactones, a process for the preparation thereof, and the use thereof. It is possible with the aid of Penicillium strains to prepare new 10-membered ring lactones having a pharmacological action.... | 02/18/1992 |
| 4914216 | Amycin and its derivatives, a process for their preparation, and their use Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.... | 04/03/1990 |
| 4873347 | Process for the preparation of the demalonyl compound of macrolide lactones It is possible to prepare the demalonyl compound of macrolide lactones by hydrolysis in the presence of a base without a retro-aldol cleavage occurring.... | 10/10/1989 |
| 4757132 | Cyclic polyester oligomer polymerization Cyclic polyester and especially polyarylate oligomers, typically having degrees of polymerization from 2 to about 7, are prepared by reacting a bisphenol such as bisphenol A or 6,6'-dihydroxy-3,3,3',3'-tetramethylspiro(bis)indane with a dicarboxylic ... | 07/12/1988 |
| 4703128 | Guanidylfungin derivatives and their production The feature of the present invention is a process for preparing compounds represented by general formula (Ia) described below: ##STR1## wherein X1, X2, X3, R1, R2, R3 and R7 ... | 10/27/1987 |
| 4672131 | Compounds and methods useful for the synthesis of thromboxane A2 Compounds having the structure: ##STR1## wherein X may be hydrogen, bromine, chlorine, fluorine or iodine are provided, together with methods for synthesizing these compounds, pharmaceutical compositions and use therof for reducing vascular blood ... | 06/09/1987 |
| 4650881 | Synthesis of isocoumarins via thallation-olefination of arenes Arenes, such as benzoic acid and substituted benzoic acids, are readily thallated by thallium(III) compounds such as the trifluoroacetate and subsequently reacted with palladium chloride and simple olefins, dienes, allylic halides, vinyl halides, vinyl es... | 03/17/1987 |
| 4647666 | Heterocyclic synthesis via thallation and subsequent palladium-promoted olefination Functionally substituted arenes selected from the group consisting of p-tolylacetic acid, N-methylbenzamide, benzamide and acetanilide which are thallated provide an organothallium salt which undergoes subsequent palladium promoted olefination to provide ... | 03/03/1987 |
| 4622313 | O-sulfate derivatives of avermectins and milbemycins having improved water solubility There are disclosed novel O-sulfate derivatives of avermectin and milbemycin. The avermectin and milbemycin O-sulfate derivatives have improved water solubility compared to the parent avermectin and milbemycin compounds and have utility as anti-parasitic ... | 11/11/1986 |
| 4616034 | 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof The present invention provides novel compounds of Formula I ##STR1## which are pharmacologically selectively useful as anti-thrombotic agents with minimal blood pressure lowering activity.... | 10/07/1986 |
| 4425356 | Lankacidin derivatives used in swine husbandry Compound of the formula: ##STR1## wherein R1 is .dbd.O or ##STR2## and R2 and R3 are each hydrogen or carboxylic acid-derived acyl, are effective for prophylaxis or treatment of swine dysentery or for increa... | 01/10/1984 |
| 4421689 | Derivatives of 1,5-dimethylbicyclo [3,2,1] octane, the preparation of these compounds and their use as perfume compound Derivative compounds of 1,5-dimethylbicyclo [3,2,1] octane of the general formula ##STR1## and perfume compositions containing these derivatives, wherein X represents a C.dbd.O group, a ##STR2## group or a ##STR3## group, in which... | 12/20/1983 |
| 4367238 | Phenyl-alkanoic acid derivative and preparation thereof This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.... | 01/04/1983 |
| 4239772 | Allyl and propyl zearalenone derivatives and their use as growth promoting agents Resorcylic acid lactone compounds of the formula: ##STR1## wherein -A- is either --CH2 --CH2 -- or --CH.dbd.CH; >Z is either >CH2, >C.dbd.0 or >CH-OH; and R and R1 are either H or a C3 group sele... | 12/16/1980 |
| 4188332 | Trans-2,3-didehydro-9-deoxy-9-methylene-PGF,1,11- or 1,15-lactones The present specification relates to novel 9-deoxy-9-methylene-trans-2,3-didehydro-PGF compounds with improved pharmacological properties. While these compounds are useful in inducing a wide variety of prostaglandin-like pharmacological effects, they are ... | 02/12/1980 |
| 4174456 | 9-Deoxy-9-methylene-inter-oxa-13,14-didehydro-16-phenyl-17,18,19,20-tetra nor-PGF1 compounds The present invention relates to novel 9-deoxy-9-methylene-interoxa-13,14-didehydro-16-phenyl-17,18,19,20-tetrano r-PGF1 compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-... | 11/13/1979 |
| 4168386 | 9-Deoxy-9 -methylene-inter-phenylene-13,14-didehydro-16-phenyl-17,18,19,20-tetranor -PGF1 compounds The present invention relates to novel 9-deoxy-9-methylene-inter-phenylene-13,14-didehydro-16-phenyl-17,18,19,20- tetranor-PGF1 compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the correspondi... | 09/18/1979 |
| 4166912 | 9-Deoxy-9-methylene-inter-phenylene-16-phenyl-PGF compounds The present invention relates to novel 9-deoxy-9-methylene-inter-phenylene-16-phenyl-PGF compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.... | 09/04/1979 |
| 4166187 | 9-Deoxy-9-methylene-16-phenyl-5,6-didehydro-PGF2 or 4,4,5,5-tetradehydro-PGF1 compounds The present invention relates to novel 9-deoxy-9-methylene-16-phenyl-5,6-didehydro-PGF2, or 4,4,5,5-tetradehydro-PGF1 compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corr... | 08/28/1979 |
| 4165436 | Trans-2,3-didehydro-9-deoxy-9-methylene-PGF compounds The present specification relates to novel 9-deoxy-9-methylene-trans-2,3-didehydro-PGF compounds with improved pharmacological properties. While these compounds are useful in inducing a wide variety of prostaglandin-like pharmacological effects, they are ... | 08/21/1979 |
| 4156782 | 9-Deoxy-9-methylene-13,14-didehydro-16-phenyl-PGF compounds The present invention relates to novel 9-deoxy-9-methylene-13,14-didehydro-16-phenyl-PGF compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.... | 05/29/1979 |
| 4144253 | 9-Deoxy-9-methylene-PGF-type lactones This invention comprises certain analogs PGE or 11-deoxy-PGE compounds in which the carbonyl at C-9 is replaced by methylene. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the a... | 03/13/1979 |
