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| Number | Title | Issue Date |
| 7745645 | Sulfonamide derivatives of xanthene compounds Compounds having the general of formula I and/or formula II ... | 06/29/2010 |
| 7674918 | Fluorescent dyes and complexes A fluorescent dye comprising a xanthene-derived fluorophore having the formula (I) wherein R1, R2, R3, R4, R5 and R6 are independently selected from H, alkyl, alkoxy, alcohol, ether, alkenyl, alkenoxy... | 03/09/2010 |
| 7667051 | Method of obtaining urethane-protected N-carboxyanhydrides of alpha amino acids The invention relates to a method of preparing urethane-protected N-carboxyanhydrides of alpha amino acids. The inventive method enables the synthesis of urethane-protected N-carboxyanhydrides of alpha amino acids in the presence of a catalytic quantity of triethyle... | 02/23/2010 |
| 7560574 | Halogenated rhodamine derivatives and applications thereof Compounds of formula (I) wherein: one of R1, R2, R3, R4 and (R10)n represents halogen and each remaining R1, R2, R3, R4 and R10 group is independently selected from hydrogen, halogen, amino, acylamino, dialkylamino, cycloal... | 07/14/2009 |
| 7432298 | Fluorescent polymeric materials containing lipid soluble rhodamine dyes Fluorescent polymeric materials are disclosed comprising a polymer and one or more lipid soluble rhodamine dyes. The materials are especially useful in the preparation of multicolored microparticles, especially multicolored polystyrene microparticle, for use in the ... | 10/07/2008 |
| 7399639 | Sensors, and methods of making and using the same The present invention is directed, in part, to sensors for detecting metal ions, and methods of making and using the same. ... | 07/15/2008 |
| 7311767 | Processes for preparing phase change inks Processes for preparing phase change inks comprising admixing (a) a phase change ink carrier; (b) a colorant of the formula or mixtures thereof, wherein M1, z, A1, R1, R2 | 12/25/2007 |
| 7301025 | Colorant compounds Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +p wherein p is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromo... | 11/27/2007 |
| 7282575 | Functional peptide nucleic acid monomer and process for producing the same A compound represented by the general formula (I) below: In the formula, A is as defined in the specification and B denotes where n is an integer of 1 to 4, ... | 10/16/2007 |
| 7270801 | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and ti... | 09/18/2007 |
| 7256275 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 08/14/2007 |
| 7220868 | Process for the preparation of novel dyes for use in imaging members There are described novel rhodamine dye compounds and imaging members and imaging methods, including thermal imaging members and imaging methods, utilizing the compounds. The dye compounds exhibit a first color when in the crystalline form and a second color, differ... | 05/22/2007 |
| 7205120 | Substrates and assays for β-secretase activity The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are d... | 04/17/2007 |
| 7176317 | Colorant compounds Compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, a, b, c, d, Y, Q, Q—, A, and CA are as defined herein. ... | 02/13/2007 |
| 7148066 | Dye solutions for use in methods to detect the prior evaporation of anhydrous ammonia and the production of illict drugs Systems and methods providing for the introduction of a dye, particularly a xanthene dye, and more particularly a rhodamine dye, to liquid anhydrous ammonia to discourage theft of the anhydrous ammonia and provide for leak detection in storage vessels. The dye will ... | 12/12/2006 |
| 7102005 | Compositions and methods for detection and isolation of phosphorylated molecules The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules... | 09/05/2006 |
| 7083667 | Colorant compound, ink, ink tank, recording unit, recording apparatus and recording process Disclosed herein is a colorant compound represented by the following general formula (1): wherein R1 and R2 are the same or different from each other and denote a linear alkyl group having 1... | 08/01/2006 |
| 7049073 | Double stranded nucleic acid biochips This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector... | 05/23/2006 |
| 7033424 | Phase change inks Phase change ink compositions comprising a phase change ink carrier and a colorant compound of the formula wherein M is either (1) a metal ion having a positive charge of +y wherein y is an integer which is at least 2, ... | 04/25/2006 |
| 7026111 | Methods and reagents for improved cell-based assays The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more particularly to improved reagents for use in cell-based assays, especially ... | 04/11/2006 |
| 7008759 | Dyes and use thereof in imaging members and methods There are described novel rhodamine dye compounds and imaging members and imaging methods, including thermal imaging members and imaging methods, utilizing the compounds. The dye compounds exhibit a first color when in the crystalline form and a second color, differ... | 03/07/2006 |
| 6998493 | Colorant compounds Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +p wherein p is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromogen moi... | 02/14/2006 |
| 6979530 | Peptide conjugates and fluorescence detection methods for intracellular caspase assay Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with ... | 12/27/2005 |
| 6967250 | Energy transfer dyes Energy transfer dyes, their preparation, and their use as labels in biological systems is disclosed. The dyes are preferably in the form of cassettes which enable their attachment to a variety of biological materials. The dyes and the reagents that can be made from ... | 11/22/2005 |
| 6916925 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds arc useful, inter alia, for determining the binding and/or receptor sites of the molecules. ... | 07/12/2005 |
| 6825166 | Molecular conjugates for use in treatment of cancer A molecular conjugate is provided having the formula: wherein n is the conjugation number, P is a moiety of a carrier molecule such as a protein, R1 is a moiety of a biologically active molecule or its analo... | 11/30/2004 |
| 6713622 | 4,7-dichlororhodamine dye labeled polynucleotides A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R1-R6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfo... | 03/30/2004 |
| 6630588 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.... | 10/07/2003 |
| 6630578 | Thioether derivatives, their method for production and use Novel dendritic molecules are provided which respond immediately by emission of light when stimulated with light or electric energy, and are useful, for example, as switching material of memory. The dendritic molecules have a core, a branch structure comp... | 10/07/2003 |
| 6608213 | Fluorescence-labeled probe for DNA and a fluorescence-labeled plasmid This invention provides a precursor compound of a novel fluorescence-labeled probe for DNA, prepared by covalent binding of a fluorescent substance such as fluorescein isothiocyanate, wherein a conjugating group was bounded, with aminoalkylate phenylamine... | 08/19/2003 |
| 6566030 | Methods and compositions for imaging acids in chemically amplified photoresists using pH-dependent fluorophores A method of imaging acids in chemically amplified photoresists involves exposing to radiation a chemically amplified photoresist comprising a pH-dependent fluorophore. Upon exposure to radiation, such as deep-UV radiation, the chemically amplified photore... | 05/20/2003 |
| 6482938 | Compounds having energy transfer function and method for DNA base sequencing by using the same Disclosed are compounds having two kinds of reporters that can be a donor and an acceptor for energy transfer, for example, fluorescent groups, and having a 2', 3'-dideoxyribonucleotide residue or a 3'-deoxyribonucleotide residue. These compounds can be u... | 11/19/2002 |
| 6455271 | Identification of novel antimicrobial agents using membrane potential indicator dyes Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.... | 09/24/2002 |
| 6376669 | Dye labeled imidazoquinoline compounds Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.... | 04/23/2002 |
| 6342611 | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell l... | 01/29/2002 |
| 6248904 | Fluorescence dyes and their applications for whole-cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell l... | 06/19/2001 |
| 6201134 | Diaminorhodamine derivatives A compound represented by the following general formula: ##STR1## wherein R1 and R2 represent amino groups present at adjacent positions each other on the phenyl ring; R3, R4, R5 and R6 ind... | 03/13/2001 |
| 6187913 | Covalently crosslinked oligonucleotides, preparation method and synthon which is of use in the method A double- or single-stranded oligonucleotide comprising one or more respectively inter- or intra-oligonucleotide covalent cross-linkages, wherein the or each covalent linkage consists of an amide bond between a primary amine group of one strand and a carb... | 02/13/2001 |
| 6162931 | Fluorinated xanthene derivatives The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes... | 12/19/2000 |
| 6143516 | Identification of novel antimicrobial agents using membrane potential indicator dyes Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.... | 11/07/2000 |
