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| Number | Title | Issue Date |
| 7361352 | Influenza immunogen and vaccine A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably e... | 04/22/2008 |
| 7282597 | Ascorbic acid derivatives and skin-whitening cosmetics It is an object to provide an L-ascorbic acid derivative which can keep the L-ascorbic acid stable to heat and light and thus has a long shelf life, which is high in permeability into the skin, which can be quickly hydrolyzed by phosphatase, an enzyme that is ubiqui... | 10/16/2007 |
| 7223775 | Stabilized ascorbic acid derivatives An ascorbic acid derivative, which is a compound represented by the following general formula (1) or a salt thereof: [Chemical Formula 11] (1)(wherein X and Y each represents H or a protective group for OH, R1 and R2 each represents an alkyl gr... | 05/29/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
| 7193092 | Chiral diphosphorus compounds and their transition metal complexes The present invention relates to chiral diphosphorus compounds and their transition metal complexes, to a process for preparing chiral diphosphorus compounds and their transition metal complexes and also to their use in asymmetric syntheses. ... | 03/20/2007 |
| 7115659 | Method of treating a condition by administering a prostaglandin derivative 2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified α-chain and an Ω-chain bonded to a ring structure. The modified α-chain has a 2-decarboxy-2-phosphinico group. The derivatives can be used to treat a variety ... | 10/03/2006 |
| 7081533 | Cycloaliphatic/aromatic diphosphines and use thereof in catalysis The present invention concerns novel unsymmetrical chiral diphosphines of a mixed aliphatic-aromatic type and processes for synthesizing them, complexes of these compounds and their use as catalysts. ... | 07/25/2006 |
| 7074942 | 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use 2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified α-chain and an Ω-chain bonded to a ring structure. The modified α-chain has a 2-decarboxy-2-phosphinico group. The derivatives can be used to treat a variety ... | 07/11/2006 |
| 7045546 | Stabilized derivatives of ascorbic acid-3-phosphate Novel derivatives of ascorbic acid and compositions comprising them are provided. The novel derivatives are of the following general formula (I): where R1 is a C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl ; R2 is a ... | 05/16/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6939864 | Animal feed compositions and methods of using the same Compositions comprising beta-glucan and ascorbic acid and methods of using the same to improve well-being of animals are provided. The combination of beta-glucan and ascorbic acid exhibit a synergistic effect on the well-being of animals. ... | 09/06/2005 |
| 6921756 | Inhibitors of β-lactamase The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 07/26/2005 |
| 6914109 | Process for the preparation of 15-pentadecanolide The invention relates to a process for the preparation of 15-pentadecanolide by hydrogenating 15-pentadecenolide and to its use. ... | 07/05/2005 |
| 6894175 | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use 2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified α-chain and an Ω-chain bonded to a ring structure. The modified α-chain has a 2-decarboxy-2-phosphinico group. The derivatives can be used to treat a variety ... | 05/17/2005 |
| 6590107 | Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pha... | 07/08/2003 |
| 6500811 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 12/31/2002 |
| 6472406 | Sulfonamidomethyl phosphonate inhibitors of beta-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel ଲ-lactamase inhibitors, which are structurally unrelated to the nat... | 10/29/2002 |
| 6436989 | Prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solu... | 08/20/2002 |
| 6388098 | Process for preparing ascorbic acid-2-monophosphate salt A process for preparing a high-purity ascorbic acid-2-monophosphate salt in a convenient manner and in a high yield, comprising hydrolyzing an ascorbic acid-2-polyphosphate or a salt thereof in the presence of magnesium ion at a pH of 7 or more.... | 05/14/2002 |
| 6344567 | Process for producing ascorbic acid-2-phosphoric ester salts A process for producing an ascorbic acid-2-phosphoric ester salt, where an ascorbic acid-2-phosphoric ester salt solution reduced in the content of excess phosphoric acid or a salt thereof mingled in the solution can be obtained from a solution containing... | 02/05/2002 |
| 6337406 | Asymmetric catalysis based on chiral phospholanes and hydroxyl phospholanes Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymmetric reactions.... | 01/08/2002 |
| 6323339 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glyc... | 11/27/2001 |
| 6316491 | Radicicol derivatives Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: ##STR1## wherein R1 and R2 are the same or different, and each represents h... | 11/13/2001 |
| 6288243 | Process for purifying L-ascorbyl 2-monophosphate A process for separating L-ascorbyl 2-monophosphate from a mixture of the products of the desalting of the product mixture obtained from the phosphorylation under basic conditions of an L-ascorbic acid salt is described. This process is characterized by p... | 09/11/2001 |
| 6281390 | Chiral diphenyldiphosphines and d-8 metal complexes thereof Compounds of formula III, ##STR1## wherein R6 und R7 signify identical or different secondary phosphino; R8 is --CH2 --OH, --CH2 --NH2 --, --CH2 O----B--FU, --CH2 --NH... | 08/28/2001 |
| 6271397 | L-ascorbic acid-2-phosphoric acid potassium crystal and method for producing the same A high-purity L-ascorbic acid-2-phosphoric acid potassium crystal having excellent stability, and a method for simply producing the high-purity L-ascorbic acid-2-phosphoric acid potassium in a high yield by adding dropwise a solution containing L-ascorbic... | 08/07/2001 |
| 6242615 | Process for the preparation of N-(3-hydroxy-succinyl)-amino acid derivatives Processes for preparing compounds of the formula (I) are described: P1 OOC--CH(OH)--CHR1 --CONH--Z wherein P1 is hydrogen or a protecting group, Z is a group --CHR2 COOP2 or --CHR2 CONR | 06/05/2001 |
| 6121464 | Preparation of salts of ascorbyl 2-phosphoric esters A process for preparing salts of ascorbyl 2-phosphoric esters of the formula I, ##STR1## where the variables have the following meanings: M is sodium, potassium, magnesium, aluminum; ##STR2## k.sym. is the valence and m=equivalents, where t... | 09/19/2000 |
| 6054444 | Phosphonic acid derivatives The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit... | 04/25/2000 |
| 6040335 | Therapeutics for thrombocytopenia Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: ##STR1## (where R is a group --NHCHR1 R2, --N(CHR1 R2)2, --N(CHR1 R2)CHR... | 03/21/2000 |
| 5916915 | Water-in-stable L-ascorbic acid derivative and a method for preparation thereof, and a skin-whitening cosmetic composition containing the same Disclosed herein are a L-ascorbic acid derivative having an improved water-in-stability, represented by a following general formula (I): ##STR1## and a method for preparation thereof, and to a skin-whitening cosmetic composition containing the same a... | 06/29/1999 |
| 5849933 | Process for producing ascorbic acid-2-monophosphates The process for manufacturing ascorbic acid 2-mono-phosphates from ascorbic acid 2-polyphosphates, in particular 2-triphosphates by subjecting the ascorbic acid 2-triphosphates to drying conditions.... | 12/15/1998 |
| 5846753 | Chemiluminescence-based method for rapid and sensitive in-situ detection of organophosphorus compounds and metal ions A method of detecting the presence of a substance being monitored in a medium, selected from the group of substances including organophosphorus compounds and the metal ions Zn, Be and Bi, including the steps of: providing a 1,2-dioxetane phenyl phosphate ... | 12/08/1998 |
| 5830871 | Inhibitors of E-, P- and L-selectin binding Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition reaction is catalyzed by aldolase. The inhibitors exhibit... | 11/03/1998 |
| 5750516 | Phosphoric diester This invention provides a phosphoric diester of formula (I) which is available on di-esterification of phosphoric acid with L-ascorbic acid involving its 5-hydroxyl group and tocopherol involving its hydroxyl group or a pharmacologically acceptable salt t... | 05/12/1998 |
| 5698584 | 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases c... | 12/16/1997 |
| 5610122 | 3-aryl-4-hydroxy-delta3-dihydrofuranone derivatives The present invention relates to a new 3-aryl-4-hydroxy-Ɗ3 -dihydrofuranone derivatives of the general formula (I) ##STR1## in which the radicals A, B, G, X, Y, Z and n have the meaning given in the description, to a plurality of processe... | 03/11/1997 |
| 5605795 | Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor Dioxetane compounds reactable with an enzyme to release optically detectable eneregy are disclosed. These compounds have the formula: ##STR1## wherein T is a cycloalkyl group or a fused polycyclo-alkylidene group bonded to the dioxetane ring through ... | 02/25/1997 |
| 5602115 | Bisphosphonic acid derivatives as anti-arthritic agents The bisphosphonates of formula (III) R2 --X--(CW)m1 --CR3 R4 --CH2 --CM[PO--(OR1)2 ]2 (III) bicyclic bisphosphonates (V), and cyclic bisphosphonates (VII... | 02/11/1997 |
