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| Number | Title | Issue Date |
| 7329654 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their prepar... | 02/12/2008 |
| 7312203 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to 1-aza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumo... | 12/25/2007 |
| 7301705 | Alicyclic compound for optical material The alicyclic compound of the present invention has a five- or more membered ring structure having an epithioethylene linkage and/or an epidithioethylene linkage, and has tow or more sulfur atoms in its molecule. Optical materials produced by curing the alicyclic co... | 11/27/2007 |
| 7226943 | Benzothiepine ileal bile acid transport inhibitors The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the tre... | 06/05/2007 |
| 7166583 | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof The present invention relates to 1,3-diaza-dibenzoazulene derivatives, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of ... | 01/23/2007 |
| 7087765 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 08/08/2006 |
| 6890715 | Sensors of conducting and insulating composites The present invention provides a class of sensors prepared from at least a first material having a positive temperature coefficient of resistance and a second non-conductive or insulating material compositionally different than the first material that show an increa... | 05/10/2005 |
| 6858732 | Photochromic benzodioxine fused naphthopyran compounds, compositions and articles containing those naphthopyran compounds Benzodioxino-naphtho[1,2-b]pyran compounds having particularly advantageous photochromic properties, such as, high sensitivity/coloration, two distinct absorption bands in the 430-500 nm range and 520-620 nm range of the visible spectrum may be generally described a... | 02/22/2005 |
| 6750244 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 06/15/2004 |
| 6723731 | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as define... | 04/20/2004 |
| 6602898 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof Compounds represented by formula (1), ##STR1## wherein X is, for example, CH, CH2, CHR (wherein R is a lower alkyl group or a substituted lower alkyl group) or CRR' (wherein R and R' are the same as the above defined R); Y is, for example, CH, ... | 08/05/2003 |
| 6566535 | Processes for the preparation of 2,3-dihydrothiepine derivatives A process for preparing a compound represented by the following formula: ##STR1## wherein each symbol is as defined below, or a salt thereof, characterized by subjecting a compound represented by the following formula: ##STR2## wherein R1 is an... | 05/20/2003 |
| 6525086 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 02/25/2003 |
| 6521769 | Chiral phosphines, transition metal complexes thereof and uses thereof in asymmetric reactions Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include chiral C1-C6 TunaPhos ligands. The ruthenium TunaPhos complex reduces ketones to the corresponding alcohols... | 02/18/2003 |
| 6489481 | Method for treating neurological disorders Treatment or the prevention of neurological disorders in a warm-blooded mammal, by use of a compound of formula VIII ##STR1## wherein A, B, R2, R3, R4, R5, R8, R9 and n are as defined in th... | 12/03/2002 |
| 6433187 | Certain polycyclic compounds useful as tubulin-binding agents Derivatives of known tubulin-binding compounds are provided in which a (poly)fluorobenzene, a fluoropyridine, or a fluoronitrobenzene moiety is incorporated or added to the structure. These derivatives can be used as antimitotic agents and can be consider... | 08/13/2002 |
| 6420417 | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions... | 07/16/2002 |
| 6315928 | Spirofluorenopyrans The present invention relates to specific photochromic 3H-naphtho[2,1-b]pyran derivatives and to their use in plastics of all types, especially for ophthalmic purposes. In particular, the present invention relates to spiro compounds derived from naphthopy... | 11/13/2001 |
| 6297260 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least o... | 10/02/2001 |
| 6268392 | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions... | 07/31/2001 |
| 6211227 | Tricyclic compounds The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I): ##STR1## (wherein R1 represents hydrogen, substituted or unsubstitut... | 04/03/2001 |
| 6207837 | Process for producing dibenzo[b,f]thiepine derivatives Efficient synthesis of diaryl sulfide derivatives useful as intermediates for pharmaceutical compounds. Provision of a convenient process for producing large quantities of dibenzo[b,f]thiepine derivatives using such intermediates. Halogen-substituted phen... | 03/27/2001 |
| 6180659 | Tracheal smooth muscle relaxant The present invention offers a tracheal smooth muscle relaxant containing the compound represented by the following formula (1) or pharmacologically acceptable salt thereof as an effective ingredient. ##STR1## [In the formula, X and Y each is any group se... | 01/30/2001 |
| 6111115 | Preparation of 2-(10,11-dihydro-10-oxodibenzo-[b,f]thiepin-2-yl) propionic acid A process for preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid (i.e., Zaltoprofen) is performed by subjecting 2-(4-amino-3-carboxy-methylphenyl)propionic acid or its salt to diazotization and subsequent reaction with thio... | 08/29/2000 |
| 6096780 | Quaternary ammonium salts and their use This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: ##STR1## wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is --CH2 --, --S-- or... | 08/01/2000 |
| 6060468 | N-substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R1a, R2, R2a, p, r and s are as defined in the detailed part of the presen... | 05/09/2000 |
| 6057441 | Substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R1 and R | 05/02/2000 |
| 6054474 | Heterocyclic compounds for the treatment of pain and use thereof Polycyclic alkaloids of formula (I), ##STR1## wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH... | 04/25/2000 |
| 5990104 | Polycyclic alcaloid-derivatives as NMDA-receptor antagonists Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH)--NH2, ... | 11/23/1999 |
| 5952512 | Production of optically active benzothiepin salts A method of producing an amine salt of an optically active benzothiepin derivative, which is characterized by allowing a benzothiepin derivative represented by the formula (I) ##STR1## wherein R stands for a lower alkyl group, to react with an optica... | 09/14/1999 |
| 5939452 | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists The invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists of formula I and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds, and to a meth... | 08/17/1999 |
| 5902516 | Five-coordinate phosphorous compound, process for producing the same and its use A five-coordinate phosphorous compound which is useful as an stabilizer for organic materials and represented by the formula (I): ##STR1## wherein R1, R2, R4 and R5 independently represent hydrogen atom, an... | 05/11/1999 |
| 5734067 | Anti-oxidative tricyclic, condensed heterocyclic compound Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condens... | 03/31/1998 |
| 5726325 | Tricyclic compounds The present invention relates to tricyclic compounds represented by general formula (I) which are useful as therapeutic agents for urinary incontinence: ##STR1## wherein R1 represents hydrogen and the like; --X1 --X2 ... | 03/10/1998 |
| 5684041 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carb... | 11/04/1997 |
| 5684031 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 ... | 11/04/1997 |
| 5679703 | Tricyclic compounds having ACAT inhibiting activity Disclosed is a tricyclic compound represented by formula (I): ##STR1## where X1 -X2 represents CH.dbd.CH--CH.dbd.CH, CH.dbd.CH--CH.dbd.N or S--CH.dbd.CH; Y--Z represents CH2 --O or CH2 --S; then L--M represents ... | 10/21/1997 |
| 5672620 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbo... | 09/30/1997 |
| 5631210 | Herbicidal thiophene ketones Compounds of Formula I and their agriculturally suitable salts are disclosed which are useful for controlling undesired vegetation ##STR1## wherein Q is ##STR2## and R1 through R7, m, n, p and q are as defined in the d... | 05/20/1997 |
| 5527801 | Ameliorant for blood lipid metabolism The present invention is to provide an ameliorant for blood lipid metabolism which comprises as an active ingredient N-(6,11-dihydrodibenzo[b,e]thiepin-11-yl)-4-(4-fluorophenyl)-1-piperazineb utanamide or a pharmaceutically acceptable salt thereof, more pa... | 06/18/1996 |
