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| Number | Title | Issue Date |
| RE39558 | 5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis Compounds of this formula are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease. ... | 04/10/2007 |
| 6916346 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is selected from C1 to C5 alkyl or hydroxyalkyl, a C3 to C | 07/12/2005 |
| 6900243 | Phenylheteroalkylamine derivatives There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their pre... | 05/31/2005 |
| 6890920 | Quaternary ammonium compounds Novel quaternary ammonium compounds of the formula and any stereoisomers thereof, wherein R1, R2 and R3 independently represent C1-C6 alkyl, optionally substituted... | 05/10/2005 |
| 6821998 | Arylamines as inhibitors of chemokine binding to US28 Methods for treating CMV and CMV-related diseases are provided that use compounds having the formula: wherein the subscripts m and n are each independently integers from 1 to 2; and the R group... | 11/23/2004 |
| 6812244 | Naphthyl compounds, intermediates, compositions, and methods of use The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use. ... | 11/02/2004 |
| 6774244 | Primary intermediates for oxidative coloration of hair Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R is selected from C1 to C5 alkyl or hydroxyalkyl, a C3 to C | 08/10/2004 |
| 6680336 | Cyclic AMP-specific phosphodiesterase inhibitors Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as ce... | 01/20/2004 |
| 6608212 | Process for preparing vinylaromatic compounds The present invention provides a process for preparing a vinylaromatic compound comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with a vinylphosphate in the presence of a palladium catalyst. The prese... | 08/19/2003 |
| 6541471 | Benzenesulphonamide compounds A compound of formula (I): ##STR1## wherein: G represents a group such as: ##STR2## wherein R1 and R2 independently represent a hydrogen atom or an alkyl, cycloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or h... | 04/01/2003 |
| 6509356 | 1-(4-(Substituted alkoxy)benzyl)naphthalene compounds having estrogen inhibitory activity A class of substituted benzylnaphthylene compounds of the structure ##STR1## where R1 and R2 are independently hydrogen, alkyl of one to six carbon atoms, acyl of two to six carbon atoms, or phenacyl; X is --(CH2)1-6 | 01/21/2003 |
| 6444688 | Compounds and compositions with nitrogen-containing non-basic side chains The instant invention provides compounds of formula I ##STR1## wherein R1 is OH, O--C(O)--(C1 -C6 alkyl), O--C(O)--O(C1 -C6 alkyl), O--C(O)--Ar, or O--C(O)--O--Ar; R2 is H, OH, O(C1 -... | 09/03/2002 |
| 6362373 | Chiral amino alcohols and process for preparation of same The disclosed invention comprises a compound having the formula: ##STR1## in which R1 and R2 independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the... | 03/26/2002 |
| 6323345 | Process for Cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine This invention provides an improved process for cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine which is an intermediate for the preparation of (-)cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tet... | 11/27/2001 |
| 6307087 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-fo... | 10/23/2001 |
| 6201130 | N-arylsulfonylamino acid omega-amides Compounds of the formula I: ##STR1## stereoisomeric forms, and physiologically tolerable salts thereof are suitable for the production of pharmaceuticals for the therapy and prophylaxis of disorders involving matrix-degrading metalloproteinases.... | 03/13/2001 |
| 6197770 | Alkenyl- and alkynl-containing metalloprotease inhibitors Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I): #... | 03/06/2001 |
| 6100428 | Nickel promoted guanylation of amines with isothioureas and thioureas An improved method for guanylating amines is provided. Broadly, the amines are reacted with a guanylating agent in the presence of a nickel catalyst. Preferably, the nickel catalyst comprises nickel in the zero oxidation state. Suitable nickel(0) catalyst... | 08/08/2000 |
| 5998443 | Phosphorous containing benzothiophenes for treating estrogen deficiency This invention relates to the fields of pharmaceutical and organic chemistry and provides novel phosphorous-containing benzothiophene compounds which are useful for the treatment of the various medical indications associated with post-menopausal syndrome,... | 12/07/1999 |
| 5948809 | (-) cis-6(S)-phenyl-5(R)4-(2-pyrrolidin-1-yl ethoxy) phenyl!-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrate (-)Cis-6(S)-phenyl-5(R)-4-(2-pyrrolidin-1-yl ethoxy)phenyl!-5,6,7,8-tetrahydro-naphthalen-2-ol D-tartrate, pharmaceutical compositions comprising this compound, and an advantageous process for preparing the compound.... | 09/07/1999 |
| 5877196 | N-4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties The present invention relates to substituted ω-phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl! alkyl, alkenyl or alkynyl!amine carboxamides, sulfonamides and phosphonylamides which are useful as antiarrhythmic agents.... | 03/02/1999 |
| 5686464 | 3,3-diphenylpropylamines, their use and preparation A 3,3-diphenylpropylamine of the formula I, or its physiologically acceptable acid salt thereof: ##STR1## wherein R1 represents hydrogen or methyl, R2 and R3 independently represent hydrogen, methyl, methoxy, hydroxy,... | 11/11/1997 |
| 5565611 | Process for preparing acid addition salt of Z-isomer of triphenylethylene compound The present invention provides a process for preparing an acid addition salt of the Z-isomer of a compound of the formula ##STR1## wherein R1 and R2 represent a lower alkyl group, or taken together with the nitrogen atom to whic... | 10/15/1996 |
| 5565612 | Substituted 2-chloro-3,4,5-trifluorobenzenes and a process for their preparation The present invention relates to substituted 2-chloro-3,4,5-trifluorobenzenes of the formula ##STR1## in which R is NO2, NH2, CN or Cl, and to a process for the preparation of substituted 2-chloro-3,4,5-trifluorobenzenes of the ... | 10/15/1996 |
| 5552412 | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis Compounds of this formula ##STR1## are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.... | 09/03/1996 |
| 5525633 | Triaryl-ethylene derivatives The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.... | 06/11/1996 |
| 5500443 | New benzodioxane compounds A compound of formula (I): ##STR1## in which: X represents oxygen or methylene, n represents 1, 2 or 3, R1 represents hydrogen, aminocarbonyl or hydroxymethyl, R2 represents: ##STR2## in which R3 and R4 ar... | 03/19/1996 |
| 5416210 | Antimicrobial polymeric quaternary ammonium salts In one aspect, compounds, methods of using them, compositions comprising such compounds, and uses of such compositions. These objects, and others which will become apparent from the following disclosure, are achieved by the present invention which comprises in... | 05/16/1995 |
| 5321138 | Compounds having glutathione peroxidase activity and use thereof The present invention provides compounds having glutathione peroxidase activity and, therefore, are effective glutathione peroxidase replacements. These compounds are useful as drugs for the prevention of cataracts and as anti-oxidants for H2 O... | 06/14/1994 |
| 5272144 | Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio-alkenylene derivatives of amines and pharmaceutical use Aryloxy- and heteroaryloxy-alkylene derivatives of amines of formula ##STR1## wherein each of A and B is a group of formula (i) to (iii): ##STR2## wherein Y is --O--, --S-- or --NR-- in which R is hydrogen or C1 -C6 alkyl;... | 12/21/1993 |
| 5250562 | Stilbene derivatives Compounds of the formula ##STR1## wherein R1 and R2 each independently are lower-alkyl; or together are alkylene with 3-5 C-atoms in a straight chain; one of the residues R3 and R4 is hydrogen and the other... | 10/05/1993 |
| 5192799 | Coumaran group containing amine compounds and their acid addition salts and quaternary ammonium salts and the use thereof as anti arrhythmic agents and as psychotropic agents Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for t... | 03/09/1993 |
| 5071844 | 5,11-dihydrodibenzo[b,e][1,4]-thiazepines useful as gastro intestinal selective calcium antagonists The invention provides compounds of the formula: ##STR1## wherein k is 1, 2 or 3; m is 1, 2 or 3; n is 1, 2 or 3; p is 0, 1 or 2; X is O, S or a direct link, with the proviso that when X is O or S, n is 2 or 3; R1 is H or C1-C.sub.4 ... | 12/10/1991 |
| 5068245 | Fungicidal N-substituted 3-arylpyrrolidine derivatives N-Substituted 3-arylpyrrolidine derivatives of the formula ##STR1## where R1 is 2,2-dimethylpropyl, 3,3-dimethylbutyl, 4,4-dimethylpentyl, 2,4,4-trimethylpentyl, 6-methylhept-2-yl, 3,5,5-trimethylhexyl, 6,10-dimethylundec-2-yl, 3-methylcyc... | 11/26/1991 |
| 5068246 | Fungicidal N-substituted 3-alkyl-4-arylpyrrolidine derivatives 3-Alkyl-4-arylpyrrolidine derivatives of the formula ##STR1## where R1 is alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkyl-cycloalkyl, cycloalkyl-alkyl, alkyl-cycloalkyl-alkyl, cycloalkenyl-alkyl, alkyl-cycloalkenyl, bicycloalkyl, bicyclo... | 11/26/1991 |
| 5017572 | Derivatives of 1-[3-(4-hydroxyphenyl) 1-hydroxy 1-propyl] benzene substituted in position 2 by an aminoalkyleneoxy chain, the method of preparing same and the application thereof to therapeutics The present invention relates to compounds of formula: ##STR1## in which: R1 and R2 are such that: either R1 represents a methoxy group in which case R2 is a group chosen from the following: hydroxyl; C1 | 05/21/1991 |
| 4999361 | Trisubstituted amines, pharmacologically acceptable salts thereof and pharmaceutical compositions containing them The present invention provides compounds of the general formula ##STR1## wherein R1 is a hydrogen atom, a straight-chained or branched C1 -C12 -alkyl radical, a C3 -C7 -cycloalkyl radical, a stra... | 03/12/1991 |
| 4996215 | Piperidine derivative and pharmaceutical composition containing the same A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: ##STR1## in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, ... | 02/26/1991 |
| 4933346 | Diarylalkyl piperazine derivatives, a process for their preparation, their use, and medicaments containing them Compounds I are described ##STR1## with R1 equal to (cyclo)alk(en)yl or ##STR2## R2 /R3 equal to phenyl or phenylalkyl, A equal to ##STR3## m equal to 2-4, and n equal to 1-4. Compounds I and their salts ar... | 06/12/1990 |
| 4906634 | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents, especially as antiarrhythmic agents are described. Pharmaceutical formulations containing such compounds are also discussed.... | 03/06/1990 |
