Class 548/572 - The -C(=X)- is part of a -C(=X)X- group wherein the X's are the same or diverse chalcogens (e.g., 3-pyrrolidinemethanol propionates, etc.)

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein is part of a X group, in which the X"s
No. of patents: 98
Last issue date: 02/26/2008

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Number	Title	Issue Date
7335680	Pyrrolidine derivatives as prostaglandin modulators Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm la...	02/26/2008
7148362	Process for the preparation of enantiopure pyrrolidin-2-one derivatives The present invention relates to a process for the preparation of enantiopure intermediates useful in the synthesis of valuable pharmaceutically active compounds, e.g. MAOB inhibitors, and to novel intermediates of formulae I and II	12/12/2006
6797723	Heterocycle substituted diphenyl leukotriene antagonists The invention relates to novel heterocycle substituted diphenyl leukotriene B4 (LTB4) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases. ...	09/28/2004
6737409	Dolastatin 10 derivatives Novel anti-tumor compounds of formula, are disclosed. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), the use of compounds of formula (I) for the treatment of cancer, and processes for...	05/18/2004
6579971	Method of producing 3,4-dehydroprolines and 3,4-dehydropiperidines A process for preparing compounds of the formula I ##STR1## in which R is hydrogen, C1 -C6 -alkoxy, --NHC1 -C6 -alkyl, --N(C1 -C6 -alkyl)2, OH, NH2 R1 is hydroge...	06/17/2003
6534650	Benzisoxazole and 4-amidino-3-hydroxyphenyl chemical intermediates This invention relates to compounds of Formula V H--Y--G--R V and Formula VI ##STR1## (wherein f, X, Y, G and R have the values defined in the description) which are useful as intermediates for the preparation of compounds, or pharmaceutically acceptabl...	03/18/2003
6512120	Methods for the synthesis of densely functionalized pyrrolidine intermediates This invention is directed to methods of synthesizing densely functionalized pyrrolidine compounds through the use of intramolecular Diels Alder reactions....	01/28/2003
6479518	Zwitterionic tachykinin receptor antagonists The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R3, R5, R6, R7, R8, R11, R	11/12/2002
6380241	Treatment of diseases using endothelin antagonists A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin....	04/30/2002
6355632	Naphthyl compounds, intermediates, compositions, and methods The present invention provides pharmaceutically active compounds formula I ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --OCOC6 H5, --OCO(C1 -C6 alkyl), or --OSO2 (...	03/12/2002
6331537	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and pr...	12/18/2001
6245801	Branched alkyl pyrrolidine-3-carboxylic acids ##STR1## Branched alkyl pyrrolidines of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropatnologica...	06/12/2001
6211226	11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension 11-aza analogs of PGF2଱ and methods of their use in treating glaucoma and ocular hypertension are disclosed....	04/03/2001
6201130	N-arylsulfonylamino acid omega-amides Compounds of the formula I: ##STR1## stereoisomeric forms, and physiologically tolerable salts thereof are suitable for the production of pharmaceuticals for the therapy and prophylaxis of disorders involving matrix-degrading metalloproteinases....	03/13/2001
6177427	Treatment of glaucoma and ocular hypertension Compositions of non-steroidal glucocorticoid antagonists for treating glaucoma or ocular hypertension and methods for their use are disclosed....	01/23/2001
6174879	Aminocyclohexylesters and uses thereof Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com...	01/16/2001
6147224	2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar...	11/14/2000
6100428	Nickel promoted guanylation of amines with isothioureas and thioureas An improved method for guanylating amines is provided. Broadly, the amines are reacted with a guanylating agent in the presence of a nickel catalyst. Preferably, the nickel catalyst comprises nickel in the zero oxidation state. Suitable nickel(0) catalyst...	08/08/2000
6084120	ଲ-Alkoxyacrylates against malaria The present invention relates to compounds having the formulae ##STR1## wherein R, R1, R6, R7, Rn8, X, and Z are defined herein, which are useful in the treatment or prophylaxis of malaria. The compounds of...	07/04/2000
6057342	Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a...	05/02/2000
5998401	Naphthyl compounds, intermediates, compositions, and methods A class of substituted phenoxy naphthalene compounds of the structure: ##STR1## where n is 2 or 3; R1 is hydrogen, hydroxy, C1 -C4 alkoxy, phenoxycarbonyl, C1 -C6 alkoxycarbonyl, or C2 -C	12/07/1999
5965119	Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: B is a leaving group or a residue of an amine-containing target moiety; G ...	10/12/1999
5962507	O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R1 and R2	10/05/1999
5955608	Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents Novel processes for producing benzothiophenes employing ethylene carbonate or propylene carbonate are provided....	09/21/1999
5935585	Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment ...	08/10/1999
5932595	Matrix metalloprotease inhibitors The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds....	08/03/1999
5919786	N,N-disubstituted amic acid derivatives The present invention relates to a compound of the formula (I): ##STR1## wherein Ar1, Ar2, Ar3 and Ar4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be s...	07/06/1999
5917086	Purification process A method for the purification of a keto acid having the general formula ##STR1## wherein R1 and R2 independently represent a straight or branched chain alkyl of 1-18 carbon atoms, a cycloalkyl of 4-8 carbon atoms or a phenyl both of which may be subs...	06/29/1999
5863903	Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes The present invention relates to hydroxy alkyl piperidine compounds and pharmaceutical compositions thereof which can be used to treat diabetes....	01/26/1999
5741799	Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as defined...	04/21/1998
5731434	Endothelin antagonists A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin....	03/24/1998
5731436	Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents Processes for producing benzothiophenes employing ethylene carbonate or propylene carbonate are provided....	03/24/1998
5691356	Disubstituted heterocyclic thrombin inhibitors Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q is a single bond or ##STR3## and Z...	11/25/1997
5661161	Inhibitors of farnesyl-protein transferase The present invention comprises analogs of the CAAX motif of the protein Ras that is modified by farnesylation in vivo. These CAAX analogs inhibit farnesyl-protein transferase. Furthermore, these CAAX analogues differ from those previously described as in...	08/26/1997
5656656	Tartronic acids, their acetalic ethers and O-esters Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C2 -C12 acyl group, R is phenyl and n is 0...	08/12/1997
5620971	Biologically active acylated amino acid derivatives The present invention relates to novel compounds which possess a broad range of useful biological activities. These compounds can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. They can also suppress, modify, or...	04/15/1997
5614548	Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions Quaternary amine-containing ether lipid analogs of the formula R1 --X--R2 --N+ (R3) (R4) (R5) Z- are disclosed. R1 represents a hydrophobic group and R2 represents th...	03/25/1997
5559248	Retinoid-like heterocycles This invention relates to a compound of formula I ##STR1## in which T is --CONH-- or --CH.dbd.CH--; Ra and Rb are independently C1-6 alkyl; Rc is C1-6 alkyl or hydrogen; and R is heteroaryl and these compo...	09/24/1996
5494921	Fibrinogen receptor antagonists Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##...	02/27/1996
5489562	Herbicide comprising acivicin and ଱-methyl derivatives thereof A herbicidal composition having acivicin, its derivatives or salts or combinations thereof as its active component. A process for controlling unwanted plants comprising applying a herbicidally effective amount of acivicin, its derivatives or salts or comb...	02/06/1996

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Class 548/572 - The -C(=X)- is part of a -C(=X)X- group wherein the X's are the same or diverse chalcogens (e.g., 3-pyrrolidinemethanol propionates, etc.)