Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7524971 | 1,5-diarylpyrrole derivatives, preparation method thereof and application of same in therapeutics The invention relates to compounds having formula (I): Wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein. The invention also relates to a method of ... | 04/28/2009 |
| 7323490 | Pyrrole compounds and uses thereof The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treat... | 01/29/2008 |
| 7314885 | Pyrrole compounds useful as kinase inhibitors The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for making the compounds and methods of using the compositions in the treatm... | 01/01/2008 |
| 7241803 | Compounds for inhibition of HIV infection by blocking HIV entry A group of compounds that inhibit HIV replication by blocking HIV entry was identified. Two representative compounds, designated NB-2 and NB-64, inhibited HIV replication (p24 production) with IC50 values | 07/10/2007 |
| 7186749 | Pyrrolo-naphthyl acids and methods for using them The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 03/06/2007 |
| 7176323 | Process for the production of γ-keto acetals A process for the production of a γ-ketoacetal compound wherein the desired product is obtained by a simple procedure in a high yield as a high purity product. The reaction scheme for the process is as follows: ... | 02/13/2007 |
| RE39420 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses Compounds of formula (I) and (II): [wherein R is hydrogen, halogen or alkyl; R1 is alkyl, amino or substituted amino; R2 is optionally substituted phenyl; R3 is hydrogen, halogen or optionally sub... | 12/05/2006 |
| 6967107 | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the pr... | 11/22/2005 |
| 6911468 | Tyrosine phosphatase inhibitors A compound of the formula (I): wherein X1 and X2 are the same or different and each is a bond or a spacer having 1 to 20 atom(s) in the main chain; one of... | 06/28/2005 |
| 6887952 | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the pr... | 05/03/2005 |
| 6887893 | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumors and tumor-related disorders and cachexia. ... | 05/03/2005 |
| 6811573 | Dyes for keratin fibres containing 1,3-diamino-4-heteroarylbenzene derivatives and novel 1,3-diamino-4-heteroarylbenzene derivatives Colorants for keratin fibers containing 1,3-diamino-4-heteroarylbenzene derivatives of general formula (I) or the physiologically tolerated salts thereof as well as novel 1,3-diamino-4-heteroarylbenzene derivatives. | 11/02/2004 |
| 6541639 | Efficient ligand-mediated Ullmann coupling of anilines and azoles The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.... | 04/01/2003 |
| 6515143 | Method for producing ortho-alkylated benzoic acid derivatives The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I ##STR1## characterized in that an aryl bromide of the formula II ##STR2## is reacted with a secondary or tertiary organolithium compound an... | 02/04/2003 |
| 6489480 | Group-15 cationic compounds for olefin polymerization catalysts This description addresses fluorinated amine compounds meeting the general formula R'i ArF--ER2, where ArF is a fluoroaryl group, E is nitrogen or phosphorous, each R is independently a C1 -C20 hydrocarbyl group... | 12/03/2002 |
| 6451824 | Sulfonylaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 09/17/2002 |
| 6451736 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides compounds of the formula (I): ##STR1## wherein R1, R2, R3 and Z are as defined in the specification. The compounds are useful as herbicides.... | 09/17/2002 |
| 6433002 | Pesticidal 1-polyarylpyrroles A compound of formula (I): ##STR1## compositions containing them and methods of use to control pests.... | 08/13/2002 |
| 6432881 | 2-benzoylcyclohexane-1,3-dione as herbicides 2-Benzoylcyclohexane-1,3-diones of formula I : ##STR1## where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, --OR3, --OCOR3, --OSO2 | 08/13/2002 |
| 6417372 | Stable arylpyrrole particles, process for their preparation and suspension concentrate compositions comprising them The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surp... | 07/09/2002 |
| 6414005 | Heterocyclic compounds having nos inhibitory activities Compounds represented by the general formula (1): ##STR1## [wherein R1 is typically an aminoalkyl group; R2 is typically a hydrogen atom, a lower alkyl group, R3 or SR4 (where R4 is typically a lower ... | 07/02/2002 |
| 6316486 | Alkyl dihalogenated phenyl-substituted ketoenols useful as pesticides and herbicides The present invention relates to new compounds of the formula (I) ##STR1## in which X represents halogen, Y represents halogen or alkyl and Z represents halogen or alkyl, with the proviso that always one of the radicals Y and Z represents halogen while the oth... | 11/13/2001 |
| 6248765 | Imidazole derivatives as histamine receptor H3 (ANT) agonists Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, havi... | 06/19/2001 |
| 6242613 | Stable arylpyrrole particles, process for their preparation and suspension concentrate compositions comprising them The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surp... | 06/05/2001 |
| 6110958 | Pyrrole compounds having parasiticidal properties Compounds of formula (I) ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.... | 08/29/2000 |
| 6022379 | Pyrrole derivatives of 1,4-naphthoquinone and of 1,4-dihydroxynaphthalene for dyeing keratin fibers, compositions comprising the same, and dyeing process Pyrrole derivatives of 1,4-naphthoquinone and of 1,4-dihydroxynaphthalene, dye compositions containing them and the corresponding dyeing process.... | 02/08/2000 |
| 6013836 | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines This invention relates to N'-substituted-N,N'-disubstitutedhydrazines of formula I ##STR1## wherein X and X' are independently O, S, or NR; A' and B' are independently substituted or unsubstituted aryl or aromatic heterocycle; wherein F is alkyl... | 01/11/2000 |
| 6004903 | 2-Anylocyclohexanediones having improved herbicidal properties Benzoyl derivatives of the formula I ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen, Q is a cyclohex... | 12/21/1999 |
| 5935990 | Substituted pyrrolyl compounds for the treatment of inflammation A class of pyrrolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I ##STR1## wherein R1, R2, R3 and R4... | 08/10/1999 |
| 5908858 | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses Compounds of formula (I) and (II): ##STR1## wherein R is hydrogen, halogen or alkyl; R1 is alkyl, amino or substituted amino; R2 is optionally substituted phenyl; R3 is hydrogen, halogen or optionally substituted al... | 06/01/1999 |
| 5849775 | Substituted benzoylguanidines process for their preparation, their use as a medicament or diagnostic, and pharmaceutical containing them Benzoylguaridines of the formula I ##STR1## are described in which: R(1), R(2), R(3), R(4), R(5) are as defined in the specification, and pharmaceutically tolerated salts thereof.... | 12/15/1998 |
| 5824691 | Guanidine derivatives as inhibitors of Na+ /H+ exchange in cells Guanidine derivatives of the formula: ##STR1## wherein Y is C--R1 (in which R1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) R2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., R3 is hydrogen, lower alko... | 10/20/1998 |
| 5763610 | Composition and processes for treating subterranean formations A composition comprising a nitrogen-containing olefinic compound and a process for using the nitrogen-containing olefinic compound to produce a water-soluble polymer which has applications in a subterranean formation are provided. The nitrogen-containing ... | 06/09/1998 |
| 5726324 | 1-(nitroaryl)pyrrole intermediates to pesticidal 1-(haloaryl)pyrroles Process for preparing complex pesticidal 1-(haloaryl)heterocyclic compounds by reacting 1-(nitroaryl)heterocycles with metallic halide salts. 1-(Nitroaryl)pyrrole intermediates useful in said process.... | 03/10/1998 |
| 5665739 | Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them Benzoylguanidines of the formula I are described ##STR1## in which R(1)=hydrogen, Hal, --NO2, --C.tbd.N, --CF3, R(4)--SOm or R(5)R(6)N--SO2 --, R(4) and R(5) are alk(en)yl or CF3, R(5) also havin... | 09/09/1997 |
| 5573999 | ଲ-substituted cinnamic acid derivative ଲ-Substituted cinnamic acid derivatives of the formula 1, ##STR1## where R1 is alkyl, chlorine or bromine, --X-- is --O--, --S--, ##STR2## m is 0 or 1, --Y is --OR4, --O--N.dbd.CR5 R6, --NR7 | 11/12/1996 |
| 5482942 | (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertension as well as for ... | 01/09/1996 |
| 5371239 | Methods and compositions for protecting animals against attack and infestation by helminth, acarid and arthropod endo- and ectoparasites This invention relates to methods and compositions for treating, controlling, preventing and protecting warm-blooded animals from infestation and infection by helminths, acarids and arthropod endo- and ectoparasites by administering or applying to the ani... | 12/06/1994 |
| 5366984 | Methyl -arylacrylates substituted by a heterocyclic radical and their use Methyl -arylacrylates substituted by a heterocyclic radical and having the general formula ##STR1## where R is alkyl, alkenyl, haloalkyl, cycloalkyl, alkoxy, alkylcarbonyl, alkoxycarbonyl, halogen or aryl, the aromatic ring being unsubstituted... | 11/22/1994 |
| 5292755 | USPA benzolyguanidines Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O)n -- or R(7)R(8)N--O2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O)... | 03/08/1994 |
