Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7902380 | Process for the preparation of ()-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and ()-alpha-ethyl-2-oxo-pyrrolidineacetamide A process provided for the preparation of the (S)- and (R)- alpha- ethyl-2-oxo-1-pyrrolidineacetamide of formula:(1) from (RS)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid of formula:(2) comprising: i) combining the (RS)-2 with a chiral base (resolving agent) in a res... | 03/08/2011 |
| 7419999 | Gamma lactams as prostaglandin agonists and use thereof 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing pr... | 09/02/2008 |
| 7402605 | 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the comp... | 07/22/2008 |
| 7335680 | Pyrrolidine derivatives as prostaglandin modulators Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm la... | 02/26/2008 |
| 7253198 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elev... | 08/07/2007 |
| RE39744 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group... | 07/24/2007 |
| 7235581 | 4-pyrrolidino-phenyl-benzyl ether derivatives The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoam... | 06/26/2007 |
| 7217826 | 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particula... | 05/15/2007 |
| 7214803 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence,... | 05/08/2007 |
| 7192979 | EP4 receptor selective agonist in the treatment of osteoporosis This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutic... | 03/20/2007 |
| 7148362 | Process for the preparation of enantiopure pyrrolidin-2-one derivatives The present invention relates to a process for the preparation of enantiopure intermediates useful in the synthesis of valuable pharmaceutically active compounds, e.g. MAOB inhibitors, and to novel intermediates of formulae I and II | 12/12/2006 |
| 7122682 | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues The present invention relates to an improved process for the preparation of (S)-(−)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R | 10/17/2006 |
| 7045639 | Method for purifying N-(2-hydroxyethyl)-2-pyrrolidone A method for purifying N-(2-hydroxyethyl)-2-pyrrolidone (HEP) is disclosed. The method comprises crystallizing crude HEP to produce HEP crystals and a mother liquor, and separating the HEP crystals from the mother liquor. In one method of the invention, crystallizat... | 05/16/2006 |
| 7015320 | Process for the manufacture of optically active 3-substituted lactams by asymmetric hydrogenation of 3-alkylidenelactams The present invention relates generally to processes for the efficient production optically active 3-substituted lactams of formula (I) process, comprising: contacting a compound of formula (II): ... | 03/21/2006 |
| 7005442 | 8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification. ... | 02/28/2006 |
| 6977303 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence,... | 12/20/2005 |
| 6906097 | 8-azaprostaglandin analogs as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 06/14/2005 |
| 6906200 | Production of N-vinyl pyrrolidone N-vinyl pyrrolidone is produced by dehydration of N-hydroxyethyl pyrrolidone in the presence of an amorphous mixed oxide catalyst such as an amorphous Ca/Zn oxide catalyst. ... | 06/14/2005 |
| 6900336 | 8-aza-11-deoxy prostaglandin analogues This invention relates to compounds which are generally EP4 receptor agonists and which are represented by Formula I: wherein A is a —CH2—CH2—, or —CH═CH—; B is absent, an a... | 05/31/2005 |
| 6897323 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reaction sequence,... | 05/24/2005 |
| 6872745 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutica... | 03/29/2005 |
| 6849657 | 2-pyrrolidone derivatives as prostanoid agonists This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I: wherein Q, B, X, J, Z, A and R1-R6 are as defined, their s... | 02/01/2005 |
| 6831039 | 3-(heterocyclyl)-substituted benzolpyrazols The invention relates to 3-(heterocyclyl)-substituted benzoylpyrazois of formula (I), wherein the variables have the following meanings: X is O, NH or N-alkyl; R1 is alkyl; R2, R3, R4, R5 are hydrogen, alkyl or ... | 12/14/2004 |
| 6812240 | 8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification. ... | 11/02/2004 |
| 6784167 | 17-beta-hydroxysteroid dehydrogenase-II inhibitors 17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group —C(R4)(R6)Y are oriented cis to each other; W represents O or S; R... | 08/31/2004 |
| 6770763 | Asymmetric synthesis of amino-pyrrolidinones A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described. These compounds are useful as intermediates for MMP and TACE inhibitors. ... | 08/03/2004 |
| 6734206 | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 05/11/2004 |
| 6734201 | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification. ... | 05/11/2004 |
| 6686477 | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same The present invention relates to highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using therefor. The invention involves a multi-step synthesis to produce the lactam compounds. In one step of the reactio... | 02/03/2004 |
| 6642266 | EP4 receptor selective agonists in the treatment of osteoporosis This invention is directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone frac... | 11/04/2003 |
| 6613795 | Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments Disclosed are enantiomerically pure cyclic aminoalcohol esters of arylcycloalkylhydroxycarboxylic acids with at least 90% enantiomeric excess of the (3R,2'R), (3S,2'R), (3R,2'S), or (3S,2'S) configured enantiomer.... | 09/02/2003 |
| 6610730 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: ##STR1## where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containi... | 08/26/2003 |
| 6552067 | EP4 receptor selective agonists in the treatment of osteoporosis This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, ##STR1## wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those ... | 04/22/2003 |
| 6512120 | Methods for the synthesis of densely functionalized pyrrolidine intermediates This invention is directed to methods of synthesizing densely functionalized pyrrolidine compounds through the use of intramolecular Diels Alder reactions.... | 01/28/2003 |
| 6509359 | Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors A compound having the formula: ##STR1## wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.... | 01/21/2003 |
| 6420415 | Thiol compounds, their production and use Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R1... | 07/16/2002 |
| 6392104 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): ##STR1## wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or ... | 05/21/2002 |
| 6340751 | Process for the preparation of 4-substituted azetidinone derivatives Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II)... | 01/22/2002 |
| 6307060 | Enantiomerically pure basic N-heterocyclic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments Disclosed are enantiomerically pure cyclic aminoalcohol esters of arylcycloalkylhydroxycarboxylic acids with at least 90% enantiomeric excess of the (3R,2'R), (3S,2'R), (3R,2'S), or (3S,2'S) configured enantiomer.... | 10/23/2001 |
| 6294568 | 5-arylpyrrole derivatives The present invention provides compounds represented by the general formula (I): ##STR1## and a salt thereof, and anti-inflammatory agents and antitumor agents containing the compounds as the active ingredients.... | 09/25/2001 |
