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Class 548/541 - Chalcogen attached directly to the five-membered hetero ring by nonionic bonding (e.g., 3-pyrrolidinols, etc.)


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 243
Last issue date: 04/24/2012


1              
NumberTitleIssue Date
8163938Aminocyclohexyl ether compounds and uses thereof
Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia. ...
04/24/2012
7973176Process for production of aralkyloxypyrrolidine derivative
The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aral...
07/05/2011
7943787Preparation of pentafluorosulfanyl (SF) heterocycles: pyrroles and thiophenes
The subject invention pertains to pentafluorosulfonyl (SF5) substituted pyrroles, thiophenes, 3-pyrrolines and 2,5-dihydrothiophenes, as well as methods for their synthesis. ...
05/17/2011
7772406Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative
Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrro...
08/10/2010
7767830Aminocyclohexyl ether compounds and uses thereof
Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia. ...
08/03/2010
7754897Synthetic processes for the preparation of aminocyclohexyl ether compounds
This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabo...
07/13/2010
7652152Synthetic method of optically pure (S)-3-hydroxypyrrolidine
A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine p...
01/26/2010
7425575Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones
The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R3 are as defined above, ...
09/16/2008
7345087Aminocyclohexyl ether compounds and uses thereof
Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia. ...
03/18/2008
7326696Amino-methyl substituted tetracycline compounds
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ...
02/05/2008
7297712Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment
The present invention provides novel cationic amphiphiles capable of facilitating transport of biologically active molecules into cells wherein the said amphiphiles contain cyclic head group having polar functional groups and pharmaceutical composition useful for de...
11/20/2007
7288565Azasugar compound
The present invention provides a compound represented by the formula (I) or a salt thereof: wherein R1 represents a hydrogen atom, a C1-10 alkyl group optionally having a substituent, or a p...
10/30/2007
7271272Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate
The present invention relates to a process for the preparation of 4-aminomethyl-3-alkoxyiminopyrrolidine methane-sulfonate, a key intermediate of quinolone antibiotics. According to the process of the present invention, the total number of steps has been shortened t...
09/18/2007
7259184Ion channel modulating compounds and uses thereof
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatme...
08/21/2007
7253205Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a variety of substituents, ring A i...
08/07/2007
72355814-pyrrolidino-phenyl-benzyl ether derivatives
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoam...
06/26/2007
72178262-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particula...
05/15/2007
7214701Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ...
05/08/2007
7192979EP4 receptor selective agonist in the treatment of osteoporosis
This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutic...
03/20/2007
7189756Pyrrolidine derivatives
The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction. ...
03/13/2007
7157490Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved...
01/02/2007
7153978Method for purifying N-methyl-2-pyrrolidone
A method for purifying N-methyl-2-pyrrolidone is disclosed. The method comprises treating N-methyl-2-pyrrolidone with an alumina that desorbs less than 100 μmol/g of isobutylene between 225° C. and 400° C. in a standard tert-butyl alcohol dehydration test. The me...
12/26/2006
7101897Farnesyl transferase inhibitors
This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions a...
09/05/2006
7098238Degradation fragments
A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4
08/29/2006
7091204Sulfonamides
The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II. ...
08/15/2006
7084138Active ingredient combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro...
08/01/2006
7064218Aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions c...
06/20/2006
7060692Active ingredient combinations comprising insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro...
06/13/2006
7057036Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action
A pyrrolesulfonamide derivative having the following formula (I): wherein the ring P represented by is a pyrrole ring having the following structure:
06/06/2006
7057053Ion channel modulating compounds and uses thereof
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatme...
06/06/2006
7030138Benzamidine derivatives
A compound of a formula (1) and pharmacologically acceptable salts thereof: wherein R1 represents hydrogen, halogen, alkyl or hydroxyl; R2 represents hydrogen or halogen; R3 represents h...
04/18/2006
7026349Sulfonamides
The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II. ...
04/11/2006
6994866Combinations of active ingredients, which exhibit insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula  in...
02/07/2006
6992205Process for the production of sulfonic esters
Sulfonic acid ester derivatives represented by the general formula (4) or (5) are produced by reacting an amino alcohol derivative represented by the general formula (1) or (2) with an organic sulfonyl halide represented by the general formula (3), in a mixed solven...
01/31/2006
69697702-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
The invention concerns 2-oxo-1-pyrrolidine derivatives and a process for preparing them and their uses. The invention also concerns a process for preparing α-ethyl-2-oxo-1-pyrrolidine acetamide derivatives from unsaturated 2-oxo-1-pyrrolidine derivatives. Particula...
11/29/2005
6955921Trypsin substrate and diagnostic device, and method of using same
A compound of the formula (I) wherein R1 is a protecting group for Nα, R2 is a protecting group for NG, and R3 is aryl, and wherein the compound of formula (I) is a trypsin ...
10/18/2005
6936633Pyrrolidinone derivatives
The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones. ...
08/30/2005
6933390Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate
The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula I by reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of fur...
08/23/2005
6923835Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres
The invention relates to novel bis-para-phenylenediamine derivatives containing a pyrrolidyl group substituted with a cationic radical, to dye compositions containing them and to the process of dyeing keratin fibres using these compositions. The present inven...
08/02/2005
6872745Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutica...
03/29/2005
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