Class 548/539 - Carbocyclic ring bonded directly to the -C(=X)- (e.g., 3-benzoyl pyrrolidine, etc.)

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the group is bonded directly to a carbocyclic
No. of patents: 290
Last issue date: 12/27/2011

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Number	Title	Issue Date
8084623	Pyrrolidinyl and piperidinyl ketone derivatives and uses thereof Compounds of the formula: or pharmaceutically acceptable salts thereof, wherein m, n, Ar, R1, R2, Ra and Rb are defined herein. Also provided are pharmaceutical composit...	12/27/2011
8058455	Compound signamycin, method for production thereof, and use thereof A compound having a structure expressed by the following Structural Formula (1) and a compound having a structure expressed by the following Structural Formula (2): ...	11/15/2011
7652151	Ketopyrroles useful as ligands in organic iridium compositions The present invention provides novel ketopyrroles having structure XXIV wherein R2 is independently at each occurrence a deuterium atom, a halogen, a nitro group, an amino group, a C3-C40 ar...	01/26/2010
7429658	Synthesis of protected pyrrolobenzodiazepines A method of synthesis of a N-10 protected PBD compound of formula (I): via an intermediate of formula (II) or formula (V): ...	09/30/2008
7425642	Heteroaryl derivative A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally subs...	09/16/2008
7361663	N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing Factor Xa. The present invention is also directed to compositions cont...	04/22/2008
7329762	Prodrugs of mitotic kinesin inhibitors The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relate...	02/12/2008
7244758	N-type calcium channel blockers Compounds that are derivatives of 3-aminomethyl-pyrrolidine generally containing at least one benzhydril moiety are useful in treating conditions which benefit from blocking calcium ion channels. ...	07/17/2007
7189756	Pyrrolidine derivatives The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction. ...	03/13/2007
7164021	Opiate analogs selective for the δ-opioid receptor Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid recept...	01/16/2007
7132551	Ligands for monoamine receptors and transporters, and methods of use thereof One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine tra...	11/07/2006
7129266	Antibiotic Cyan426-A The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ether...	10/31/2006
7115754	Pyrrolidine derivatives as oxytocin antagonists The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected fro...	10/03/2006
7001905	Substituted diarylamines as MEK inhibitors Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are us...	02/21/2006
6897319	Useful aroyl pyrrole heteroaryl methanones and methanols This invention is directed to aroyl pyrrole heteroaryl methanone and methanol compounds pharmaceutically useful as agents for treating or modulating a central nervous system disorder and methods for treating or modulating a central nervous system disorder. ...	05/24/2005
6890939	Aminopyrrolidine sulfonamides as serine protease inhibitors The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders. ...	05/10/2005
6855706	Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin. ...	02/15/2005
6838565	Substituted benzoic acid amides, their preparation and their use as pharmaceutical compositions Carboxylic acid amides of general formula having an antithrombotic activity and a factor Xa-inhibiting activity. Exemplary are: (a) N-[1-(3-amidino-phenyl)-2-(1H-tetrazol-5-yl)-ethyl]...	01/04/2005
6828276	Herbicidally active benzoylcyclohexanediones There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radic...	12/07/2004
6790860	Pyrrolidine derivatives The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction. ...	09/14/2004
6759429	Pyrrole derivatives Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4	07/06/2004
6727368	Oligomers and polymers of cyclic imino carboxylic acids Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds. ...	04/27/2004
6723753	Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscle...	04/20/2004
6710186	Oligomers and polymers of di-substituted cyclic imino carboxylic acids Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds. ...	03/23/2004
6630505	Aminopyrrolidine sulfonamides as serine protease inhibitors The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders....	10/07/2003
6599930	Coniosetin and derivatives thereof, process for the preparation and the use thereof The present invention relates to novel active substances (coniosetin and coniosetin derivatives) of the formula I ##STR1## which are produced by the microorganism Coniochaeta ellipsoidea Udagawa (DSM 13856) during fermentation, wherein R, R2, R...	07/29/2003
6576657	Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, ##STR1## wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in partic...	06/10/2003
6573267	Useful aroyl aminoacyl pyrrole compounds This invention is directed to aroyl aminoacyl pyrroles pharmaceutically useful as agents and modulators for the treatment of central nervous system disorders and a method for the treatment of central nervous system disorders including, but not limited to,...	06/03/2003
6534545	Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: ##STR1## X represents: (i) either a radical of formula: (a) ##STR2## and Y represents a radical of formula: (b) ##STR3## (ii) or a radical of formula: (c...	03/18/2003
6489491	Synthesis of compounds useful in the manufacture of ketorolac A multi-step method of synthesizing ketorolac, an analgesic compound, is shown. Several of the reactions and intermediate compounds are novel. The reaction sequence begins with the known compound N-2-bromoethylpyrrole....	12/03/2002
6486169	Botanical drug for treatment and prevention of alzhimer's disease The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide (CLE) and their preparation. HUE has the following pharma...	11/26/2002
6448286	Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors....	09/10/2002
6436235	N-substituted perfluoroalkylated pyrrolidines and process for making them N-substituted perfluoroalkylated pyrrolidines of the formula III ##STR1## where RF, B, Q and q are as defined herein are prepared from diallylamine, a perfluoroalkyl iodide and an amino-reactive compound selected from the group of carboxylic ac...	08/20/2002
6384236	N-(aroyl)glycine hydroxamic acid derivatives and related compounds Compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are ...	05/07/2002
6323344	Preparation of ketorolac 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxamides of the formula ##STR1## where R1 is alkyl and R2 is optionally substituted phenyl; and the method for their preparation and their conversion to ketorolac and its pharmaceutically ac...	11/27/2001
6294531	Calcilytic compounds Novel arylalkylamino compounds exhibiting calcilytic properties are provided....	09/25/2001
6288241	Crystalline polymorphic form of 1-methyl-5-p-toluoylpyrrple-2-acetamidoacetic acid guaiacyl ester (MED 15) A new crystalline form of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid guaiacyl ester, a process for its preparation and pharmaceutical compositions endowed of anti-inflammatory, analgesic and antipyretic activity containing same are disclosed....	09/11/2001
6258833	Cyclic AMP-specific phosphodiesterase inhibitors Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, a...	07/10/2001
6248894	Fungicides for the control of take-all disease of plants A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1##...	06/19/2001
6218424	Heterocyclic ketone and thioester compounds and uses This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged ner...	04/17/2001

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Class 548/539 - Carbocyclic ring bonded directly to the -C(=X)- (e.g., 3-benzoyl pyrrolidine, etc.)