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| Number | Title | Issue Date |
| 7528264 | Hydride reduction process for preparing quinolone intermediates Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis. ... | 05/05/2009 |
| 7282517 | Method of manufacturing glimepiride and the respective intermediate A method of manufacturing glimepiride of formula I wherein trans-4-methylcyclohexylamine pivalate of formula VII is reacted, either directly or after conversion to trans-4-methylcyclohexylamine or to its another salt, with an alkyl [4-(2-{[(3-ethyl-4-methyl-2-oxo-2,... | 10/16/2007 |
| 7125442 | Lightfast additive having UV-absorbing moiety and ink composition including the same A lightfast additive and an ink composition including the same include a benzophenone moiety for lightfastness and a moiety for wettability and the ability to stabilize a colorant, wherein the two moieties are covalently bonded. The lightfast additive may exhibit ef... | 10/24/2006 |
| 7104265 | Filter containing a metal phthalocyanine and a polycationic polymer A tobacco smoke filter comprising one or more than one metal phthalocyanine, such as a copper phthalocyanine or an iron phthalocyanine, and further comprising one or more than one polycationic polymer. ... | 09/12/2006 |
| 7101880 | Peptidic compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compo... | 09/05/2006 |
| 7074447 | Antimicrobial composition comprising potassium sorbate and LAE The invention relates to a novel composition with antimicrobial activity. It is in the food industry a well-known method to use the product L-arginine, Na-lauroyl-ethylester monohydrochloride (LAE). This product is well tolerated and suitable for use in the preserva... | 07/11/2006 |
| 7022863 | Production method of pyrrolidone carboxylic acid and salt thereof The present invention provides a production method of pyrrolidone carboxylic acid or a salt thereof, which includes bringing glutamic acid or a salt thereof into contact with high-temperature high-pressure water having a temperature of above 100° C. and not higher ... | 04/04/2006 |
| 6967107 | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the pr... | 11/22/2005 |
| 6906198 | Antipicornaviral compounds, their preparation and use Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compou... | 06/14/2005 |
| 6887952 | N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the pr... | 05/03/2005 |
| 6627760 | Amorphous compound The present invention relates to a novel form of (S)-1-[N2 -(1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline known under the generic name lisinopril. Further, the present invention also relates to the use of the novel amorphous form of lisinopril ... | 09/30/2003 |
| 6403830 | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.... | 06/11/2002 |
| 6365743 | Process for the preparation of enantiomerically pure imidazolyl compounds The invention relates to a method for the preparation of an enantiomerically pure imidazolyl compound of the general formula ##STR1## wherein: n is 0 or 1; m is 1 or 2; R1 is hydrogen, methyl or ethyl; and C* denotes a chiral center; as well as its ... | 04/02/2002 |
| 6362215 | Composition for laying hens containing calcium L-pidolate The invention concerns the use of calcium L-pidolate for obtaining an agent improving the quality of eggshells and a composition capable of being administered to laying hens. Said composition is characterized in that it contains as active element for impr... | 03/26/2002 |
| 6288240 | Preparation of 2-hydroxy-5-oxoproline and analogs thereof The compound 2-hydroxy-5-oxoproline and analogs thereof may be used to produce an increase in carbon dioxide fixation, growth, dry weight, nutritional value (proteins and amino acids), nodulation and nitrogen fixation and photosynthetically derived chemic... | 09/11/2001 |
| 6133308 | Synthesis of clasto-lactacystin beta-lactone and analogs thereof The present invention is directed to an improved synthesis of clasto-lactacystin-ଲ-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies u... | 10/17/2000 |
| 6015569 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 01/18/2000 |
| 5925772 | Cysteine protease inhibitors containing heterocyclic leaving groups A class of cysteine protease inhibitors which inactivate a cysteine protease by covalently bonding to the protease and releasing a heterocyclic leaving group is presented. The cysteine protease inhibitors of the present invention comprise a first portion ... | 07/20/1999 |
| 5869675 | Lactacystin derivatives Novel lactacystin derivatives other than lactacystin per se, with superior activity for the genesis of neurites and highly selective toxicity and low cytotoxicity as compared with known lactacystin have been prepared, of the formula ##STR1## whe... | 02/09/1999 |
| 5663343 | Process for the preparation of enantiomerically pure imidazolyl compounds The invention relates to a method for the preparation of an enantiomerically pure imidazolyl compound of the general formula ##STR1## wherein n is 0 or 1; m is 1 or 2; R1 is hydrogen, methyl or ethyl; and C* denotes a chiral centre; as well as ... | 09/02/1997 |
| 5616727 | Process for purifying 1-[N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl]-l-lysyl-l-proline (lisinopril (TFA) ethyl ester A process for purifying 1-[N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl]-1-lysyl-1-proline by extraction and crystallization. The process includes a two step extraction in a two phase aqueous/organic solvent syst... | 04/01/1997 |
| 5605925 | 1-aminoacetamidopyrroles and 1-amino acetamido-2-(substituted) pyrroles and related compounds There are disclosed 1-aminoacetamidopyrroles and 1-amino-2-(substituted)pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learni... | 02/25/1997 |
| 5369122 | Process for manufacturing a humectant In a process for manufacturing a humectant with a chemical structure similar to that of natural moisture regulators, residual molasses from sugar beet molasses are treated and the organic acids contained, in particular L-2-pyrrolidone-5-carboxlyic acid an... | 11/29/1994 |
| 5364948 | Biologically active compounds isolated from aerobic fermentation of Trichoderma viride This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compou... | 11/15/1994 |
| 5306826 | Process for preparation of an optically active amino acid amide The present invention relates to a process for the preparation of optically active amino acid amide. L-amino and D-amino acid amides are mixed in the presence of 0.5-4 equivalents of an aldehyde, relative to the quantity of amino acid amide, in the presen... | 04/26/1994 |
| 5190980 | Pyroglutamic acid esters, their synthesis and use in topical products The invention relates to esters of pyroglutamic acid, their synthesis and their use in products for topical application to human skin as precursors of pyroglutamic acid.... | 03/02/1993 |
| 5134157 | Amino acid of cycloaliphatic alcohols, process for their preparation and use as drugs Amino acid esters of cycloaliphatic alcohols of the formula: ##STR1## wherein A is cyclohexyl, cyclohexenyl, cyclopentyl and cyclopentenyl, substituted with from one to three radicals which are methyl, ethyl, and/or ethenyl. These amino acid esters h... | 07/28/1992 |
| 5132433 | Process for the preparation of clausenamide and neoclausenamide, and derivatives thereof A process for the preparation of compound of the formula ##STR1## in which R1 --represents ##STR2## and R2 --represents hydrogen, fluorine, chlorine or bromine. Comprising cyclizing compounds of the formula ##STR3## ... | 07/21/1992 |
| 5110986 | Synthesis of N-t-alkyl-1,2-diacylhydrazines This application relates to a process for preparing a N-t-alkyl-1,2-diacylhydrazine by reacting a 1,3,4-oxadiazole with a tertiary alkyl cation precursor in the presence of a strong acid catalyst. Preferably, the 1,3,4-oxadiazole is a 2,5-disubstituted-1,... | 05/05/1992 |
| 5108482 | N-phenylpyrrolidines The 1-(3,5-bis-trifluoromethylphenyl)-2-thioxopyrrolidine-4-carboxylic acid derivatives of the formula I below are suitable for protecting crop plants against the phytotoxic action of herbicides and for regulating the plant growth. The 1-(3,5-bis-trifluor... | 04/28/1992 |
| 5103007 | Lipids Lipid derivatives represented by the formula: ##STR1## wherein R1 stands for an optionally substituted higher alkyl group, R2 stands for an optionally substituted lower alkyl group or an optionally substituted nitrogen-containin... | 04/07/1992 |
| 5091407 | Heterocyclic compounds as fungicides Fungicidally active compounds of the formula ##STR1## and steroisomers thereof, wherein A is the group .dbd.CW--or a nitrogen atom, B is the group .dbd.CX--or a nitrogen atom, D is the group .dbd.CY--or a nitrogen atom, and E is the group .dbd.CZ--or... | 02/25/1992 |
| 5081289 | Synthesis and isolation of nopaline and its analogues A method of separating nonpaline derivatives from their diastereoisomers is disclosed along with a method of selectively growing strains of the bacterium A. tumefaciens. Also disclosed are novel general methods of synthesizing the nopaline and isonopaline... | 01/14/1992 |
| 5081245 | Carboxylic acid derivatives A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; R1 represents a higher alkyl group which may be substituted; R2 represents a hydrogen atom or a lower alkyl group, a lower alkano... | 01/14/1992 |
| 4966901 | Pyrrole derivatives, their preparation and their use as pharmaceutical active compounds Pyrrole derivatives of the general formula I ##STR1## wherein R denotes alkyl which is substituted by --NH2 or acylamino, R1 and R2 independently of one another denote hydrogen or alkyl having 1 to 4 carbon atoms, R | 10/30/1990 |
| 4952706 | Derivatives of 2-pyrrolidone-5-carboxylic acid and method of obtaining them The new, crystalline trihydrates of sodium L- and D-2-pyrrolidone-5-carboxylate. These trihydrates can be obtained by adjusting the concentration and the temperature in an aqueous solution of sodium L- or D-2-pyrrolidone-5-carboxlate in such a manner that... | 08/28/1990 |
| 4946968 | Method of preparing alkali metal salts of 2-pyrrolidone-5-carboxylic acid Alkali metal salts of 2-pyrrolidone-5-carboxylic acid (pyroglutamic acid) are prepared by heating the corresponding alkali metal salt of glutamic acid to a temperature between its melting point and 270° C. until the water liberated by the intramolecular ... | 08/07/1990 |
| 4933354 | 2-pyrrolidone-5-carboxylic acid compounds useful for the treatment of mental disorders In one embodiment this invention provides novel 2-pyrrolidone-5-carboxylic acid compounds, and pharmaceutically acceptable salts thereof, represented by the formula: ##STR1## where n is an integer with a value of 1-4. The compounds have application ... | 06/12/1990 |
| 4921971 | Method of preparing alkaline earth metal salts of 2-pyrrolidone-5-carboxylic acid Alkaline earth metal salts of 2-pyrrolidone-5-carboxylic acid (pyroglutamic acid) are prepared by heating the corresponding alkaline earth metal salt of glutaminic acid in the solid state to a temperature in a range of 120° C. to 250° C. until the water... | 05/01/1990 |
| 4863952 | Method of promoting percutaneous drug absorption with 2-pyrrolidin-2-one 5-carboxylic acids and esters thereof A composition for percutaneous drug administration which contains a compound of the general formula ##STR1## wherein R1 is a hydrogen atom or an alkyl group and R2 is a residue of aliphatic hydrocarbon. The composition is capabl... | 09/05/1989 |
