Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7732622 | Naphthalene derivatives A compound of formula (I) wherein R1 and R3 are the same or different and represent ═O, hydrogen, C1-6alkyl, C1-6dialkyl, ═CHC1-C5alkyl, ═... | 06/08/2010 |
| 7696358 | Five-membered heterocyclyl tetracycline compounds and methods of use thereof The present invention describes methods of treating bacterial infections with 7-pyrrolyl tetracycline compounds of formula (I): ... | 04/13/2010 |
| 7265110 | Tetrahydropyran derivatives and their use as therapeutic agents The present invention relates compounds of the formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, and R10 represent a variety of substituents; A represents NR9 ... | 09/04/2007 |
| 7160877 | Aliphatic nitrogen-containing 5-membered ring compound The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH2— or —S—, ... | 01/09/2007 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7001918 | 7-pyrrolyl tetracycline compounds and methods of use thereof A compound of Formula (I): wherein variables R, R1, R2, R3 and A are as defined in the ... | 02/21/2006 |
| 6960667 | Fluorescent maleimides and uses thereof The present invention is directed to maleimides and preparation of compounds of the formula I wherein R1 and R2 independently from each other stand for | 11/01/2005 |
| 6355669 | Retinoic acid agonists as preventive and therapeutic agents for nephritis The present invention provides a therapeutic or prophylactic agent as a substitute for conventional steroids or immunosuppressive agents to treat or prevent systemic erythematosus, glomerulonephritis, lupus nephritis, idiopathic thrombocytopenic purpura o... | 03/12/2002 |
| 6140321 | Polymorphs of donepezil hydrochloride and process for production Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produce... | 10/31/2000 |
| 6057441 | Substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and q are zero to 4; r is zero to 5; R1 and R | 05/02/2000 |
| 5985864 | Polymorphs of donepezil hydrochloride and process for production Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produce... | 11/16/1999 |
| 5914324 | 6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same 6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R1, R2 and R3 ar... | 06/22/1999 |
| 5780486 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 07/14/1998 |
| 5686482 | N-(3-pyrrolidinyl) benzamide derivative N-(3-Pyrrodinyl)benzamide derivatives represented by the following general formula (I) which have potent and selective antagonism against dopamine D3 and/or D4 receptor and are useful as a psychotropic, a schizophrenia-treating agent... | 11/11/1997 |
| 5574175 | Process for the manufacture of insecticidal arylpyrroles via oxazole amine intermediates The present invention provides a process for the manufacture of 2-aryl-5-(perfluoroalkyl)pyrrole-3-carbonitrile comprising the cycloaddition of 5-amino-4-aryl-2-perfluoroalkyl-1,3-oxazole and the appropriate 1,3-dipolarifile. The arylpyrrole-3-carbonitril... | 11/12/1996 |
| 5488119 | Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R1 to R4 are H or a substituent such as phenylthio, and one of the substituents R1, R2, R3 and R4... | 01/30/1996 |
| 5274135 | Process for preparing aminobenzocyclobutenes A process for preparing a 3- or 4-aminobenzocyclobutene comprises aminating a 3- or 4-halo- or sulfonyloxybenzocyclobutene reactant with an aminating agent by heating at a temperature from about 80° C. to a temperature at which dimerization or oligomeriz... | 12/28/1993 |
| 5252317 | Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each com... | 10/12/1993 |
| 5202486 | Tetrahydroethanonaphthaleneamine derivatives Tetrahydronaphthaleneamine derivatives having the formula ##STR1## wherein R, R', R1 and R2 are as defined herein, are novel calcium channel blockers.... | 04/13/1993 |
| 5189065 | Use of derivatives of 9,10-dihydrophenanthrene for the preparation of an anti-tumor medicament The use of products of formula (I) is described, wherein X and Y represent hydrogen, hydroxy or alkoxy; and R1 and R2 represent H, alkyl, alkenyl or alkynyl, arylalkyl, acyl or R1 and R2 together with nitrogen f... | 02/23/1993 |
| 5132313 | Non-competitive NMDA receptor antagonists and methods for their use The present invention relates to novel NMDA receptor antagonists and methods for their use. The present invention also provided pharmaceutical compositions comprising such NMDA receptor antagonists.... | 07/21/1992 |
| 5093031 | Surface active lactams The invention relates to properties and uses of N-hydrocarbon substituted lactams, particularly N-alkyl substituted lactams having the formula ##STR1## wherein R' is a hydrophobic radical such as linear or branched chain alkyl group containing from 8... | 03/03/1992 |
| 5071853 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 12/10/1991 |
| 4904688 | Tricyclic amine derivatives The present invention deals with dibenzo-oxocin-, dibenzo-thiocin-, dibenzo-azocin- and dibenzocyclo-octenamine derivatives suitable for use as antipsychotic compounds without extra-pyrimidal side-effects.... | 02/27/1990 |
| 4876269 | Benoz-fused cycloalkane trans-1,2-diamine derivatives Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine compounds of the formula: ##STR1## wherein A, B, C, D, n, X, Y, R, R1, R2 and R3 are as defined in the specification, e.g., trans-3,4-dichlo... | 10/24/1989 |
| 4826996 | 1,8,-dihydroxy-9-anthrones substituted in the 10-position The invention concerns 1,8-dihydroxy-9-anthrones substituted in the 10-position of the formula: ##STR1## in which R1 represents a group taken from the set constituted by: ##STR2## wherein R2 represents H, C1-8 al... | 05/02/1989 |
| 4798894 | Gem cyclodialkylation of amines and amides Compounds containing at least one N,N-dialkylatable amino or amido group (e.g., aniline, dodecylamine, acetamide) are converted in a highly efficient manner into gem cyclodialkylated compounds by reaction with an unstrained cyclic ether (e.g., tetrahydrof... | 01/17/1989 |
| 4461899 | Fluorenecarboxylic acid derivatives A series of ester and salt derivatives of fluorene-9-carboxylic acid and fluorene-1-carboxylic acid exhibit significant plant growth regulating properties, useful in controlling the size, shape, dormancy time, flowering time and/or fruit setting of plants... | 07/24/1984 |
| 4447368 | Process for the preparation of aminoarylsulphonic acids in sulfolene solvent Aromatic aminosulphonic acids which have a reduced content of discoloring by-products are obtained when aromatic amines are reacted with a sulphonating agent in a reaction medium at least some of which consists of tetramethylene sulphone.... | 05/08/1984 |
| 4435336 | Process for the preparation of aromatic aminosulphonic acids Aminoarylsulphonic acids which have a relatively high purity and a relatively low content of aminoaryldisulphonic acids can be obtained, if they are prepared, from the corresponding arylammonium hydrogen sulphates, by an improved version of the so-called ... | 03/06/1984 |
| 4376773 | 10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo-[a,d]-cycloheptenes, their preparation, and therapeutic agents containing these compounds 10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo[a,d]-cycloheptenes, their pharmaceutically tolerated addition salts with acids, processes for their preparation, and their use as drugs, especially as sedatives, hypnotics or tranquilizers.... | 03/15/1983 |
| 4355036 | Tricyclic-substituted piperidine antihistamines Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3 or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ... | 10/19/1982 |
| 4204970 | Lubricant compositions containing alkylated aromatic amino acid antioxidants Lubricant compositions containing polymer alkylated aromatic amino acids as antioxidants and a process for the preparation of these amino acids comprising hydrolysis of cyclic keto amides formed from an intramolecular acylation of an imide of an aromatic ... | 05/27/1980 |
| 4174342 | N-(Acenaphthenyl)maleimides By the addition of a relatively small amount of N-(acenaphthenyl)maleimides carrying optional substituents, synthetic films, plastics, woven or knitted synthetic or cellulosic fabrics, or paint can be protected against fungal and bacterial deterioration.... | 11/13/1979 |
| 4156694 | Benzobicyclononene derivatives The present invention relates to novel benzo(b) bicyclo[3.3.1]nones of the general formula I: ##STR1## and a salt or nitrogen oxide thereof, in which R1 and R2 stand for hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 1-6 carbon... | 05/29/1979 |
| 4153564 | Nitrogen-containing compounds and lubricant compositions containing same Compounds that act as emulsifiers, detergents and antioxidants when added to a lubricant or a fuel are prepared from (1) an alkenylsuccinic anhydride or acid and an aniline-aldehyde resin or (2) the product of (1) and an aromatic triazole, e.g. benzotriaz... | 05/08/1979 |
| 4113726 | Perhydrofluorenetetrol and perhydrophenanthrenetetrol derivatives Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n1 is 0, 1 or 2 and n2 is 0, 1, 2 or 3, R1, R2, R3 and R4 may be the same or different and can be hydrogen, lo... | 09/12/1978 |
| 4107206 | Benzo-bicyclononene- derivatives The present invention relates to novel biologically active tricyclic compounds of the general formula: ##STR1## and salts thereof, IN WHICH R1 and R2 stand for hydroge, alkyl or alkenyl, an optionally substituted aralkyl group o... | 08/15/1978 |
| 4097488 | N-(3-fluoranthyl)maleimide; a fluorescent reagent for the studies of thiol compounds This invention relates to N-(3-fluoranthyl)maleimide which is reactive with thiol compounds forming fluorescent products, and is useful in the fields of biochemical research.... | 06/27/1978 |
| 4028400 | D-homosteroids The present invention relates to steroids. More particularly, the invention is concerned with D-homosteroids, a process for the manufacture thereof and pharmaceutical preparations containing same.... | 06/07/1977 |
