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| Number | Title | Issue Date |
| 8134013 | Amide compound and thrombopoietin receptor activator The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective. A compound represented by the formula (1): wh... | 03/13/2012 |
| 8093405 | Formation of F and F fluoroarenes bearing reactive functionalities An iodonium compound of formula (I): where RAR1 is a C5-6 aryl group, bearing at least one substituent selected from formyl, thionoacyl, acylamidocarboxy, thionoester, azo, C2-20 alkenyl,... | 01/10/2012 |
| 7423061 | Substitute thiophenes and uses thereof This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer. ... | 09/09/2008 |
| 7417062 | Substituted arylamides Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer. ... | 08/26/2008 |
| 7393846 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 07/01/2008 |
| 7326729 | CXCR1 and CXCR2 chemokine antagonists The present invention is directed to a compound having the general structure of formula (1): useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease. ... | 02/05/2008 |
| 7312179 | Cyclopropyl-thienyl-carboxamide as fungicides A fungicidally active compound of formula (I): where X is (X1), (X2) or (X3); Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, provided that the ring is not 1,2,3-triazole... | 12/25/2007 |
| 7307173 | Pyrroline chromophores Electron acceptor compounds, nonlinear optical chromophores, methods for making the compounds and chromophores, and materials and electro-optic devices that include the chromophores. ... | 12/11/2007 |
| 7301037 | Charged compounds comprising a nucleic acid binding moiety and uses therefor Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and m... | 11/27/2007 |
| 7294650 | Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β2-adrenorecept... | 11/13/2007 |
| 7288538 | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ... | 10/30/2007 |
| 7282510 | Small molecule inhibitors of rotamase enzyme activity This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prol... | 10/16/2007 |
| 7276531 | G-lactam derivatives as prostaglandin agonists A gamma-lactam diene of Formula I: which is particularly useful as a medicament for the treatment of various disorders such as asthma, hypertension, osteoporosis, sexual dysfunction and fertility disorders. ... | 10/02/2007 |
| 7273940 | Catalysts for the polymerization of unsaturated compounds Bisimine compounds of the formula (I) where the symbols have the following meanings: A is a nonmetal selected from among N, S, O and P, R1 is ... | 09/25/2007 |
| 7250415 | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I: P-M-M1I or a stereo... | 07/31/2007 |
| 7250414 | Diphenylmethyl compounds useful as muscarinic receptor antagonists This invention provides compounds of formula I: wherein a, b, c, e, m, n, Ar1, R1, R2, R3, R4a, R4b, R5 and R6 are as defined ... | 07/31/2007 |
| 7244851 | Inhibitors of IAP The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R... | 07/17/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7235544 | 3-sulfonylamino-pyrrolidine-2-one derivatives as inhibitors of factor Xa The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 06/26/2007 |
| 7235579 | Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of... | 06/26/2007 |
| 7205318 | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: P4-M-M4I or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Com... | 04/17/2007 |
| 7199149 | Monocyclic and bicyclic lactams as factor Xa inhibitors The present application describes monocyclic and bicyclic lactams and derivatives thereof of Formulae Ia–e: wherein one of one of T1 and T2 is carbonyl, thiocarbonyl, or sulfonyl or pharma... | 04/03/2007 |
| 7192978 | Pyrrolidinium derivatives New pyrrolidinium derivatives having the chemical structure of general formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy a... | 03/20/2007 |
| 7186722 | 2-heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides Novel Δ1-pyrrolines of the Formula (I) in which R1, R2, R3 and Het have the meanings given in the description, a plurality of processes for prep... | 03/06/2007 |
| 7186735 | Acylated arylcycloalkylamines and their use as pharmaceuticals The present invention relates to acylated arylcycloalkylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administering such compounds. | 03/06/2007 |
| 7183260 | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inf... | 02/27/2007 |
| 7183277 | Carboxylic acid amides Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophyla... | 02/27/2007 |
| 7179835 | 2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a Factor Xa inhibitor using the same. | 02/20/2007 |
| 7144902 | Prodrugs of thrombin inhibitors The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as ka... | 12/05/2006 |
| 7138075 | Molecular actuators, and methods of use thereof The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecul... | 11/21/2006 |
| 7138426 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 11/21/2006 |
| 7094801 | Chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ... | 08/22/2006 |
| 7091204 | Sulfonamides The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II. ... | 08/15/2006 |
| 7087638 | Pyrrolecarboxamides and pyrrolethioamides as fungicides Novel pyrrole derivatives of formula I wherein X is oxygen or sulfur; R1 is C1–C4alkyl unsubstituted or substituted, with the exception of CF3 | 08/08/2006 |
| 7078536 | Charged compounds comprising a nucleic acid binding moiety and uses therefor Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and m... | 07/18/2006 |
| 7074785 | Δ-pyrrolines used as pesticides Novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, A, R4 and m have the meanings given in the description, a number of proce... | 07/11/2006 |
| 7053056 | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inf... | 05/30/2006 |
| 7022677 | Amide derivatives as growth hormone secretagogues Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubs... | 04/04/2006 |
| 6962942 | Azacycloalkanone serine protease inhibitors The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds having F... | 11/08/2005 |
| 6951934 | Method for preparing functionalized β-(1,3)-glucan derivatives The present invention relates to a novel method of chemically preparing functionalized derivatives of β-(1,3)-glucans, enabling obtaining oligosaccharides which are free or which comprise specific groups such as, for example, sulphate, phosphate, methyl, in pre-def... | 10/04/2005 |
