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| Number | Title | Issue Date |
| 7288553 | Indole derivatives as selective androgen receptor modulator (SARMS) The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 10/30/2007 |
| 7250440 | (Hydroxyphenyl)-1H-indole-3-carbaldehyde oxime derivatives as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, and R4 are as defined in the specification, or a pharmaceutica... | 07/31/2007 |
| 7129264 | Biarylmethyl indolines and indoles as antithromboembolic agents The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L1, L2, X1, X | 10/31/2006 |
| 7125906 | Indole derivatives having anti-angiogenetic activity The invention relates to the use of a compound of Formula (I), for the manufacture of a medicament to inhibit and/or reverse and/or alleviate symptoms of angiogenesis and/or any disease state associated with angiogenesis: ... | 10/24/2006 |
| 7109351 | Fused pyrrolecarboxamides; GABA brain receptor ligands Substituted pyrrolecarboxamide compounds are disclosed. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors ... | 09/19/2006 |
| 6995262 | Use of acylsulfonamido-substituted polymethine dyes as fluorescene dyes and/or markers The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I) in which n, Y, A and R have the meaning given in the claims, and at least one compound of the formulae ... | 02/07/2006 |
| 6809098 | Compounds The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 10/26/2004 |
| 6727270 | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 04/27/2004 |
| 6699862 | Indolyl-2-phenyl bisamidines useful as antiproliferative agents Novel indolyl-2-phenyl bisamidines are described which are DNA methyltransferase inhibiting agents, and pharmaceutical compositions containing them are used as antiproliferative agents for treating a disease, especially a neoplastic disease, characterized... | 03/02/2004 |
| 6541505 | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is a... | 04/01/2003 |
| 6541632 | Process for producing heterocyclic nitriles A carbocyclic or heterocyclic compound, ammonia and an oxygen-containing gas are subjected to fluid catalytic reaction in vapor phase in the presence of a catalyst containing alkali metal to produce an aromatic or heterocyclic nitrile. The use of the cata... | 04/01/2003 |
| 6303782 | Process for preparing benzylnitriles A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1.0.0): ##STR1## comprising treating a substituted aromatic compound of Formula (2.0.0): ##STR2## with a secondary nitrile of Formula (3.0.0): ##S... | 10/16/2001 |
| 6258852 | Aryl nitrone therapeutics for the treatment of inflammatory bowel disease Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.... | 07/10/2001 |
| 5969112 | Yellow cationic dyes having flocculating properties A flocculating dye reduces bleed between two inks when they are applied side by side. A first ink comprises the flocculating dye which flocculates the dispersant-pigment of the second ink.... | 10/19/1999 |
| 5922582 | Indole alkaloid type compound 0089-D The present invention relates to compound 0089-D having excellent antitumor activity and antimicrobial activity, represented by the general formula (I): ##STR1## or pharmaceutically acceptable salts thereof.... | 07/13/1999 |
| 5814633 | Iminooxymethylene anilides, process for preparing the same and their use Iminooxymephyleneanilides of the formula I ##STR1## where the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4; R is nitro, cyano, halogen, unsubst. or subst. alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy or an u... | 09/29/1998 |
| 5789404 | 3-substituted 1-arylindole compounds 3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or -thioxo; R1 -R4 are hydrog... | 08/04/1998 |
| 5773623 | Methine dyes containing a 5- or 6- membered carbocyclic or heterocyclic radical Methine dyes of the formula ##STR1## where K is a 5- or 6-membered carbocyclic or heterocyclic radical, X is nitrogen or a radical of formula C--Q1, and Q1, Q2 and Q3 are each independently of the others hydrogen, ... | 06/30/1998 |
| 5756531 | Iminoxy derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis The present invention provides a class of substituted indole and indene iminoxy derivatives of the formula ##STR1## which inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.... | 05/26/1998 |
| 5750558 | Oxime derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis Described herein are compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein L is selected from the group consisting of ##STR2## R2 is selected from (a) ##STR3## R3 is selected ... | 05/12/1998 |
| 5705506 | Pharmaceutical compositions of alkylsulphonamides 5HT1 agonists for rectal administration The present invention relates to a pharmaceutical composition for rectal administration in solid dosage form which comprises a compound acting as a 5HT-1 like receptor agonist in the form of its free base or a physiologically acceptable hard fat base carr... | 01/06/1998 |
| 5696148 | Indole compounds and their use in treating diseases of the central nervous system The present invention relates to therapeutically active indole compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related... | 12/09/1997 |
| 5677329 | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about... | 10/14/1997 |
| 5656655 | Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase A method of inhibiting cell proliferation in a patient suffering from such disorder comprising the administration to the patient of a pharmaceutically effective amount of a pharmaceutical composition containing, in admixture with a pharmaceutically accept... | 08/12/1997 |
| 5652250 | N-substituted ଲ-aryl- and ଲ-heteroaryl--cyanoacrylamide derivatives and process for their preparation The present invention relates to new compounds of formula ##STR1## wherein A is a bicyclic ring chosen from naphthalene, tetrahydronaphthalene, quinoline, isoquinoline and indole. B is a R2 substituted benzene ring or an unsubstituted pyridine ... | 07/29/1997 |
| 5637593 | Tryptamine analogues as 5-ht1-like agonists A compound of structure (I), in which A1 is O, S(O)n in which n is 0, 1 or 2, NR, CH2, or CH(OH); A2 is a bond or CH2 ; or A1 A2 is CH.dbd.CH; R is hydrogen or C1-4 alkyl; ... | 06/10/1997 |
| 5543433 | Azine-substituted phenylacetic acid derivatives and fungicides containing these Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH3, CHOCH3 or NOCH3, R is hydrogen or alk... | 08/06/1996 |
| 5510353 | Certain aminoguanidine compounds, pharmaceutical compositions containing them and their use in treating gastrointestinal motility disorders and disorders associated with cephalic pain Compounds of formula A--X--Y--NH--B wherein A is derived from optionally substituted benzothiophene, indole, 4-aza-and 7-aza-benzothiophene or-indole, A bearing in position 5 hydrogen, halogen, optionally substituted alkyl, hydroxy, nitro, amino, alkylami... | 04/23/1996 |
| 5476935 | Dyes for use in thermal dye transfer Dye-donor element for use according to thermal dye transfer comprising least one dye corresponding to the general formula (I): ##STR1## wherein Z is --CN, --COOR1 or --CONR2 R3 ; R1 is --H, (cyclo)alkyl, or... | 12/19/1995 |
| 5463045 | Dyes and dye-donor elements for thermal dye transfer recording Dye-donor element for thermal dye transfer comprising at least one magenta dye having extremely low side absorption in the blue and red regions of the spectrum, said dye corresponding to the general formula (I): ##STR1## wherein R1 is H, (... | 10/31/1995 |
| 5420294 | Cycloalkylaminoalkoxyindoles This invention provides a method of selectively antagonizing the 5-HT1A receptor in mammals by administering aryloxypropanolamines. Aryloxypropanolamines are also claimed.... | 05/30/1995 |
| 5399574 | Indolyl tetrahydropyridines for treating migraine | 03/21/1995 |
| 5331005 | Amidines derived from 3-aminoethyl indoles and process for the preparation thereof Amidines derived from 3-aminoethyl indoles of formula (I) ##STR1## where R1 is an atom of hydrogen or a lower alkyl or alkenyl group: R2 is an atom of hydrogen or a lower alkyl or alkenyl , aryl, arylalkyl or cycloalkyl group; R... | 07/19/1994 |
| 5296519 | Indole compound and use of the same Disclosed is a novel UV light absorbing compound which can preferably be employed in the art of colored molding plastics, resin films, heat-sensitive transfer materials, liquid crystal display materials, color photographs and the like, and method for prod... | 03/22/1994 |
| 5196446 | Certain indole compounds which inhibit EGF receptor tyrosine kinase Heteroarylethenediyl compounds wherein the heteroaryl group can be mono- or icyclic heteroaryl and the aryl group can be or mono- or bicyclic carbocyclic, said compound optionally substituted or polysubstituted, with the proviso that the heteroaryl group i... | 03/23/1993 |
| 5183894 | 2-substituted-1-hydroxyindoles The present invention relates to 2-substituted-1-hydroxyindoles of the following formula: ##STR1## wherein, R1 is an electron withdrawing group, R2 is an alkenyl having 2-10 carbon atoms, and N-substituted -iminobenzyl gr... | 02/02/1993 |
| 5180728 | Pyrimidoindole derivatives and processes for preparation thereof A compound of the formula: ##STR1## wherein R1, R2 and R3 are each hydrogen, lower alkyl, lower alkenyl, aryl or ar(lower)alkyl, R4 is imidazolyl, which may have alkyl or imino-protective group as substitue... | 01/19/1993 |
| 5124449 | Azaporphyrin derivatives Azaporphyrin derivatives of the formula ##STR1## where R1 and R2 are each, independently of one another, hydrogen, unsubstituted or substituted C1 -C20 -alkyl, C5 -C7 -cycloalkyl or un... | 06/23/1992 |
| 5118695 | 1-hydroxyindole fungicides 1-Hydroxyindoles of the following formula are useful in controlling fungi: ##STR1## wherein: R1 is hydrogen or an electron withdrawing group; R2 is selected from the group consisting of alkenyl having 2-10 carbon atoms, N-substituted... | 06/02/1992 |
| 5095031 | Indole derivatives which inhibit leukotriene biosynthesis Substituted indolyl compounds of the formula ##STR1## are potent inhibitors of the lipoxygenase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.... | 03/10/1992 |
