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| Number | Title | Issue Date |
| 7473786 | Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts A copper(I)-catalyzed procedure for the synthesis of benzo[b]heterocycles. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans and indoles in good to excellent yields. This method can tolerate a variety of functional groups, does not require th... | 01/06/2009 |
| 7429612 | Indoline compound and medicinal use thereof The present invention provides an indoline compound represented by the formula (I) wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition contai... | 09/30/2008 |
| 7384973 | Materials and methods for treating hypercholesterolemia The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can ... | 06/10/2008 |
| 7381739 | 2,4-substituted indoles and methods of use The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, p and n are those defined herein. The pres... | 06/03/2008 |
| 7375118 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellu... | 05/20/2008 |
| 7371865 | Process for the manufacture of HMG-CoA reductase inhibitors The invention relates to a process for the manufacture of a compound of formula or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element represents —CH2 | 05/13/2008 |
| 7342038 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a ther... | 03/11/2008 |
| 7342039 | Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them. ... | 03/11/2008 |
| 7332521 | Substituted indoles The present invention relates generally to substituted indoles such as substituted 1H-indole-2-carboxylic acid derivatives, and methods of using them. ... | 02/19/2008 |
| 7316890 | Indolestyryl compound for use in recording media and method for fabrication thereof Indolestyryl compounds and use thereof for a high density recording media and method for fabricating the same. The indolestyryl compounds exhibit strong absorbance in the visible light region (400˜700 nm) of the spectrum, resistance to heat and light, high light se... | 01/08/2008 |
| 7294648 | Anthranyl derivatives having an anticholecystokinin activity (anti-cck-1), a process for their preparation, and pharmaceutical use thereof Anthranylic compounds having anti-CCK activity of general formula (I) in which, n is a whole number lying between 0 and 7; R1 is chosen independently from the groups (II), in which X1 is chosen independently from, S, O, NR2 and X | 11/13/2007 |
| 7288564 | Indole derivatives Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a... | 10/30/2007 |
| 7268159 | Substituted indoles The present invention relates generally to substituted indoles and methods of using them. ... | 09/11/2007 |
| 7259183 | Indole, indazole and indoline derivatives as CETP inhibitors The present invention relates to compounds of formula (I): wherein —X—Y—, R1 to R11 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. T... | 08/21/2007 |
| 7259182 | Aryl, aryloxy, and aklyloxy substituted 1-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor ... | 08/21/2007 |
| 7250526 | Transfer hydrogenation process and catalyst A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydr... | 07/31/2007 |
| 7179921 | Indoline and tetrahydro-quinolines as prodrugs for tumour treatment Compounds of the general formula I or IA or a salt in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X... | 02/20/2007 |
| 7176230 | Synthesis of indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl) indazole (YC-1) as anti-platelet agents The present invention synthesizes a series of novel indole analogs of 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (YC-1), and their anti-platelet activity. ... | 02/13/2007 |
| 7173048 | Indolyl derivatives as liver-X-receptor (LXR) modulators The invention relates to compounds of formula (I): and pharmaceutically acceptable salts and pharmaceutically acceptable esters thereof, wherein R1, R2, R3, R4, R5... | 02/06/2007 |
| 7166637 | Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active c... | 01/23/2007 |
| 7160918 | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor (PAI-1) This invention provides indole oxo-acetyl amino acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure: | 01/09/2007 |
| 7157585 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 01/02/2007 |
| 7157487 | Vla-4 inhibitors The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1-WB- (in which, WA is substituted or unsubstituted ary... | 01/02/2007 |
| 7153977 | Ligands and methods for preparing same A process is disclosed for modifying a parent ligand by attaching to the parent ligand a conjugation agent that is reactive with a moiety of a target receptor to which the parent ligand binds such that a covalent bond is formable between the conjugation agent and th... | 12/26/2006 |
| 7148240 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular... | 12/12/2006 |
| 7141600 | Small molecule inhibition of a PDZ-domain interaction Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein an... | 11/28/2006 |
| 7138527 | Indole derivatives useful for the treatment of diseases The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous... | 11/21/2006 |
| 7081536 | Isoxazoline derivatives as P N ligands The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula I and ... | 07/25/2006 |
| 7056943 | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides indole oxo-acetyl amino acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure: | 06/06/2006 |
| 7049445 | Bicyclic compounds Compounds of the general formula (I): or a salt thereof, wherein R1 is hydrogen, hydroxyl or halogen; R2 is NHSO2CH3, SO2NHCH3 or the like; R5 | 05/23/2006 |
| 7012147 | Indoline derivative and process for producing the same The present invention provides novel synthetic intermediates for the production of indoline derivatives, which exhibit excellent ACAT inhibitory activity, and processes for the preparation thereof. ... | 03/14/2006 |
| 7002019 | Synthesis of indole thiazole compounds as ligands for the Ah receptor A method of synthesizing aromatic ketone compositions of formula I comprising the step of introducing a double bond into the 5 membered ring of the 4,5-dihydro-1,3-azoles moiety of formula II is disclosed. A method of synthesizing aromatic ketone compositions of for... | 02/21/2006 |
| RE38970 | Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors A heterocyclic derivative of the formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts t... | 02/07/2006 |
| 6960611 | Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof The present invention relates to sulfonyl-containing 2,3-diarylindole, especially to new compounds of general Formula, to a preparation method for their preparation, to pharmaceutical compositions containing said compound, and to the medical use thereof in the treat... | 11/01/2005 |
| 6953809 | Monocyte chemoattractant protein-1 inhibitor compounds The invention concerns the use of a compound of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, in the treatment of a disease... | 10/11/2005 |
| 6939889 | Quarternary ammonium compounds Novel compounds and pharmaceutical compositions containing such compounds and possessing anti-tussive activity, and a method of administering the same to warm-blooded animals, including humans. ... | 09/06/2005 |
| 6933316 | Indole compounds Indole compounds of the formula: wherein L1 is CO; L2 is a bond; R1 is aryl or heteroaryl; R2 is H, aryl, heteroaryl, halogen, nitro, nitroso, cyano, azide, isothionitro, OR,... | 08/23/2005 |
| 6906094 | 1,2,4-tribsubstituted benzenes as inhibitors of 15-lipoxygenase The present invention provides compounds of formula (I) wherein R, Z, Y, W, R5, V, and X are as defined in the description, and pharmaceutically acceptable salts thereof, which are useful for the treatment of diseases responsive to the inhibition of the e... | 06/14/2005 |
| 6878170 | 5,6-Dihydroxyindolines as additives for hair dyeing preparations The invention concerns the use of indoline derivatives of formula (I): in which R1, R2, R3, R4 and R5 independently of one another represent hydrogen or C1-4 ... | 04/12/2005 |
| 6875876 | Protected aminofunctionalized polymerization initiators and methods of making and using same Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality includes a first protecting group, which can be aralkyl, methyl, allyl or tertiary alkyl group. The other of the amine protecti... | 04/05/2005 |
