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| Number | Title | Issue Date |
| 7968730 | Synthesis of amines and intermediates for the synthesis thereof The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, or especially of amides of the formula II, wherein the symbols have the mea... | 06/28/2011 |
| 7645886 | Synthesis of amines and intermediates for the synthesis thereof The invention relates in a first embodiment to a method for the manufacture of esters of the formula (I), or especially of amides of the formula (II), wherein the symbols have the meanings given in the specification, as well as other intermediates and compounds usef... | 01/12/2010 |
| 7414078 | Oral general anesthetics and metabolitically resistant anticonvulsants The present invention is directed to novel themisone derivative compounds that have been modified to prevent the formation of the toxic metabolite, 2-phenyl-acrylamide. Compositions comprising such derivative compounds have activity as anesthetics and as neuroprotec... | 08/19/2008 |
| 7396853 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds ar... | 07/08/2008 |
| 7374857 | Bismide compound, acid generator and resist composition each containing the same, and method of forming pattern from the composition The present invention relates to a novel bisimide compound useful as an acid generator for a chemically amplified resist composition used in manufacturing of semiconductor element and the like or a raw material for synthesizing heat resistant polymers, an acid gener... | 05/20/2008 |
| 7247651 | 2,7-substituted indoles The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, and n are those defined herein.... | 07/24/2007 |
| 7094908 | Reduction of carbonyl compounds using the carbonyl reductase of A compound represented by a general formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted β-keto ester and c... | 08/22/2006 |
| 7081457 | Cyclothiocarbamate derivatives as progesterone receptor modulators Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have ... | 07/25/2006 |
| 6951848 | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disc... | 10/04/2005 |
| 6906090 | Compositions and methods for treating mycobacterial diseases The invention provides the use of certain isatin and oxindole derivatives in the preparation of a medicament for use in the treatment of mycobacterial disease. ... | 06/14/2005 |
| 6852893 | Method for oxidizing hydrocarbons The invention relates to a method for oxidizing substrates such as hydrocarbons, waxes or soot. The method involves the use of a compound of formula (I) in which: R1 and R2 represent H, an aliphatic or aromatic alkoxy radical, carboxyl radical, alkoxycarbonyl radica... | 02/08/2005 |
| 6576770 | Preparation of substituted phthalic anhydrides and substituted phthalimides A process for the formation of halophthalic anhydrides and halogen substituted-n-alkyl-phthalimides from the corresponding substituted-n-alkyl-tetrahydrophthalimide by passing said substituted-n-alkyl-tetrahydrophthalimide over a metal catalyst, in the ... | 06/10/2003 |
| 6570038 | Aqueous hexasubstituted guanidinium chlorides and methods for their preparation and use Hexasubstituted guanidinium chlorides are prepared by a method which affords them in high yield as aqueous solutions, optionally also containing alkali metal chlorides. The solutions may be employed as sources of hexasubstituted guanidinium salts useful a... | 05/27/2003 |
| 6562983 | Process for the preparation of alkyl 4[2-(phthalimido)ethoxy]-acetoacetate The present invention provides a method to prepare alkyl-4-[2(phthalimido)-ethoxy]-acetoacetate which are useful in the manufacture of anti-hypertensive and anti-ischaemic drugs by reacting 2(phthalimido)-ethoxyacetic acid with thionyl chloride and then r... | 05/13/2003 |
| 6528663 | Methods for the preparation of 4-chlorophthalic anhydride A method for the synthesis of substituted phthalic anhydrides (IV) ##STR1## wherein R' is a halogen, aromatic or aliphatic group comprising 1-18 carbons, hydrogen or nitro group is the transimidation between a substituted N-alkyl phthalimide (V) ##ST... | 03/04/2003 |
| 6403792 | Sulfonyl isatin compounds and methods of blocking apoptosis therewith The present invention is to novel sulfonyl isatin compounds of Formula (I), their pharmaceutical compositions, and the novel inhibition of caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.... | 06/11/2002 |
| 6329550 | Amidomalonamides useful as inhibitors of MMP of matrix metalloproteinase The present application relates to novel aminomalonamides of the formula ##STR1## and pharmaceutical composition thereof which are useful for inhibiting matrix metalloproteinases.... | 12/11/2001 |
| 6306378 | Catalyzed water-soluble/dispersible reactive derivatives of polyimido compounds for modifying proteinaceous substrates This invention relates to a two-part system useful for treating proteinaceous substrates. The two-part system has a first part comprising a water-soluble/dispersible reactive polyimido compound and a second part comprising a nucleophilic catalytic agent. ... | 10/23/2001 |
| 6255479 | Process for the preparation of -oxolactams A method for preparing an -oxolactam comprising, reacting a corresponding -diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding -oxolactam.... | 07/03/2001 |
| 6235934 | Aqueous hexasubstituted guanidinium chlorides and methods for their preparation and use Hexasubstituted guanidinium chlorides are prepared by a method which affords them in high yield as aqueous solutions, optionally also containing alkali metal chlorides. The solutions may be employed as sources of hexasubstituted guanidinium salts useful a... | 05/22/2001 |
| 6207686 | Endothelin antagonists A compound of formula (I), in which: R1 is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2 is hydrogen, hydroxy or protected... | 03/27/2001 |
| 6159673 | Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound An oxonol compound is represented by the following formula (I): ##STR1## in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M i... | 12/12/2000 |
| 6159995 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.... | 12/12/2000 |
| 6133305 | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity The present invention relates to novel 3-(substituted)-2-indolinones compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment... | 10/17/2000 |
| 6084107 | Intermediates for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive int... | 07/04/2000 |
| 6048840 | Hypoglycaemic peptides This invention relates to novel insulin-potentiating hypoglycaemic compounds.... | 04/11/2000 |
| 5952511 | Indolin-2-one derivatives A compound represented by formula (I): ##STR1## wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl g... | 09/14/1999 |
| 5948808 | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens Provided in the present invention are compounds and compositions of substituted indole-3-carbinols and diindolylmethane suitable for treating estrogen-dependent tumors. Also provided are methods of treating such cancerous-conditions.... | 09/07/1999 |
| 5837703 | Amino-alcohol substituted cyclic compounds Therapeutic compounds have the formula: (X)j-(core moiety), j being an integer from one to three, the core moiety comprising a core moiety, the core moiety being a heterocycle having one ring or two-fused rings, each ring having five or six ring atoms, A being... | 11/17/1998 |
| 5789404 | 3-substituted 1-arylindole compounds 3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or -thioxo; R1 -R4 are hydrog... | 08/04/1998 |
| 5780498 | Endothelin receptor antagonists The present invention provides novel compounds represented by the general formula I: ##STR1## wherein R1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, l... | 07/14/1998 |
| 5776497 | Product based on inorganic or organic particles bearing an indoline-based product A mineral or organic particle-based product comprising an indoline product, a method for preparing same, and the use thereof in cosmetics. The product is a powder consisting of mineral or organic particles smaller than 200 microns, and comprises, in and/o... | 07/07/1998 |
| 5760248 | Tachykinin antagonists A description is given of tachykinin receptor antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.... | 06/02/1998 |
| 5728712 | 3,4-disubstituted-phenylsulphonamides and their therapeutic use 3,4-Disubstituted-phenylsulphonamides have therapeutic utility via TNF or phosphodiesterase inhibition.... | 03/17/1998 |
| 5717108 | Process for the preparation of indole compounds The present invention relates to a novel process for the preparation of a monohydroxyindole or dihydroxyindole compound by a single step of placing in contact, in a solvent medium, at least one hydrolase with at least one indole compound bearing one or tw... | 02/10/1998 |
| 5693663 | Substituted bicyclic 3-aryl-pyrrolidine-2,4-dione derivatives The invention relates to substituted bicyclic 3-aryl-pyrrilidine-2,4-dione derivatives of the formula ##STR1## wherein Q and A form a substituted 4- to 6-membered ring. These compounds have utility as pesticides.... | 12/02/1997 |
| 5684033 | Non-peptide tachykinin receptor antagonists This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiolog... | 11/04/1997 |
| 5646147 | Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides. The invention relates to compounds of the formula ##STR1## in which Ar... | 07/08/1997 |
| 5641783 | Substituted amino alcohol compounds Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty. Independently, R1 and R2 are hy... | 06/24/1997 |
| 5631381 | Process for the preparation of pesticidal 1-(haloaryl) heterocyclic compounds Process for preparing complex pesticidal 1-(haloaryl)heterocyclic compounds by reacting 1-(nitroaryl)heterocycles with metallic halide salts.... | 05/20/1997 |
