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| Number | Title | Issue Date |
| 7342029 | Substituted indoles Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved. ... | 03/11/2008 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6875760 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated co... | 04/05/2005 |
| 6706744 | Glucagon antagonists/inverse agonists Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein... | 03/16/2004 |
| 6114156 | Molecular level coating for metal oxide particles Polymer encapsulated metal oxide particles are prepared by combining a polyamide acid in a polar aprotic solvent with a metal alkoxide solution. The polymer was imidized and the metal oxide formed simultaneously in a refluxing organic solvent. The resulti... | 09/05/2000 |
| 6114419 | Fluorinated melt additives for thermoplastic polymers Fluorinated imides useful for imparting repellency of low surface tension fluids to thermoplastic polymers of formulae ##STR1## wherein R1 is F(CF2)x --(CH2)m, or F(CF2)x SO... | 09/05/2000 |
| 5994388 | Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis The present invention relates to inhibition of angiogenesis and the treatment of diseases mediated by angiogenesis. Particularly, the invention relates to the inhibition of neovascularization and the treatment of cancer. The invention further relates to t... | 11/30/1999 |
| 5789491 | Fluorinated melt additives for thermoplastic polymers Fluorinated imides useful for imparting repellency of low surface tension fluids to thermoplastic polymers of formulae ##STR1## wherein R1 is F(CF2)x --(CH2)m, or F(CF2)x SO... | 08/04/1998 |
| 5719295 | Process for preparing bis(ether anhydrides) using alkylamine derived bisimides having low melting temperatures A process for making bis(ether anhydrides) employs alkylamines having low melting temperatures thus allowing for novel intermediate process steps for preparing bis(ether anhydrides). The alkylamines have alkyl groups which contain at least three carbon at... | 02/17/1998 |
| 5681963 | Fluorinated melt additives for thermoplastic polymers Fluorinated imides useful for imparting repellency of low surface tension fluids to thermoplastic polymers of formulae ##STR1## wherein R1 is F(CF2)x --(CH2)m, or F(CF2)x SO... | 10/28/1997 |
| 5679700 | Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents Novel phosphinic acid-containing peptidyl compounds of formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, perio... | 10/21/1997 |
| 5641800 | 1H-indole-1-functional sPLA2 inhibitors A class of novel 1H-indole-1-functional compounds is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are 1H-indole-1-a... | 06/24/1997 |
| 5576332 | Soft ଲ-drenegic blocking agents New soft ଲ-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C6 -C12 c... | 11/19/1996 |
| 5571928 | 4-amino-3-hydroxy-phthalimidine, and a process for the preparation thereof The present invention relates to 4-amino-3-hydroxy-phthalimidine, an important intermediate for the synthesis of 3-substituted 5-quinoline-carboxylic acid amides, and a process for the preparation thereof.... | 11/05/1996 |
| 5440048 | 1-piperazinyl-2-butenes and -2-butynes Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.... | 08/08/1995 |
| 5359084 | Method of preparing aromatic ether bisimides A method for preparing an aromatic ether bisimide is provided. The mixture obtained from reacting a substituted phthalimide with a metal salt of a hydroxy aromatic compound in a non-polar solvent is extracted with about 4% to about 6% by weight aqueous al... | 10/25/1994 |
| 5288749 | Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors The present invention provides tertiary and secondary amine compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof which are antagonists for alpha-2 adrenoreceptors and which inhibit serotonin (5-hydroxytryptamine, 5... | 02/22/1994 |
| 5234942 | Heterocyclic amides and leucotriene antagonistic use thereof The invention provides a series of novel heterocyclic amides of the formula I in which the group A; CRa can be --CRb.dbd.CRa--, --CHRb--CHRa-- or --N.dbd.CRa--, the amidic group Re.L can be Rd.X.CO.NH, Re.X.CS.NH or Re.NH.CO attached to position 4, 5 or 6... | 08/10/1993 |
| 4902809 | Method for making N-substituted nitrophthalimides A process for preparing N-alkyl substituted nitrophthalimide by the nitration of N-alkyl substituted phthalimide using only nitric acid, said nitric acid having a concentration of at least about 95%, and then recovering N-alkyl nitrophthalimide from the n... | 02/20/1990 |
| 4780544 | Method for making oxybisphthalimides A method is provided for making oxybisphthalimides by heating an N-organonitrophthalimide in the presence of an aprotic organic solvent in an alkali metal carboxylate.... | 10/25/1988 |
| 4577033 | Heterocyclic quaternary ammonium salts as phase transfer catalysts for aromatic ether imide preparation Heterocyclic quaternary ammonium salts such as N,N-di-n-butylpiperidinium bromide are excellent phase transfer agents for the preparation of aromatic ethers, as by the reaction of the disodium salt of bisphenol A with 4-nitro-N-methylphthalimide.... | 03/18/1986 |
| 4554357 | Bis-quaternary salts as phase transfer catalysts for aromatic ether imide preparation Bis-quaternary ammonium and phosphonium salts such as bis(tri-n-butyl)-1,6-hexylenediammonium dibromide are excellent phase transfer agents for the preparation of aromatic ether imides, as by the reaction of the disodium salt of bisphenol A with 4-ni... | 11/19/1985 |
| 4520204 | Method for preparation of aromatic ether imides and for catalyst recovery therein The yield of aromatic ether imides prepared by reacting a substituted phthalimide (such as 4-nitro-N-methylphthalimide) with an alkali metal salt of a hydroxyaromatic compound (such as the disodium salt of bisphenol A) in the presence of a phase transfer ... | 05/28/1985 |
| 4471125 | Method for making aromatic ether imides A method is provided for making aromatic ether imides in the substantial absence of a solvent. A mixture of at least one halo-substituted phthalimide and at least one anhydrous alkali metal phenoxide salt is heated at a temperature at least sufficient to ... | 09/11/1984 |
| 4324719 | Azo dyes from aminophthalimides and aniline, tetrahydroquinoline, and benzomorpholine couplers having thiosulfate groups Disclosed are azo dyes suitable for coloring polyamide material, particularly nylon carpet and which are prepared from aminophthalimides and couplers which are ##STR1## substituted with a thiosulfate ester group. These dyes produce yellow to blu... | 04/13/1982 |
| 4289784 | Pyromellitic diimides and method of increasing feed efficiency in ruminant animals Novel substituted pyromellitic diimides are disclosed wherein the compounds are assymetrically substituted with a variety of substituent groups. Processes for the preparation of such compounds are also disclosed. The novel assymetrically substituted pyrom... | 09/15/1981 |
| 4261893 | Bis-phthalimide intermediates Bis-phthalimide intermediates of the formula: ##STR1## wherein one of R9 and R10 is hydrogen and the other is --NR11 R12 ; R11 is hydrogen or straight stain alkyl containing 1-4 carbon atoms and ... | 04/14/1981 |
| 4217281 | Imide carbonyl compounds and method for making A method is described for making organic polycarboxylic acids or anhydrides, such as aromatic ether bis(phthalic acid)s, based on a cyclic imide-cyclic anhydride exchange reaction at elevated temperatures in the presence of water. In addition to making or... | 08/12/1980 |
| 4188330 | Substituted phthalide derivatives Method of preparing chlorthalidone, an antihypertensive agent, and derivatives using a novel 3-(4'-chloro-3'-chlorosulfonylphenyl)phthalide intermediate and derivatives, and method of preparing said novel intermediate, are disclosed.... | 02/12/1980 |
| 4132711 | Process for preparing nitriles A process for the preparation of aromatic nitriles which comprises reacting an organic carboxylic acid with an aromatic o-dinitrile whereby the nitrile of the acid is obtained with cyclic imide by-product and the imide by-product is converted to dinitrile... | 01/02/1979 |
| 4129729 | 3-Phenacyl and phenacylidene phthalimidines and corresponding naphthoyl derivatives Certain 3-phenacyl and phenacylidene phthalimidines, and the corresponding naphthoyl derivatives, are novel compounds which possess biological activity in the treatment of plants to control their growth.... | 12/12/1978 |
| 4093712 | N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof N2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.... | 06/06/1978 |
| 4086243 | Intermediates in the preparation of isoxazolyl benzamides Substituted or unsubstituted isoxazolyl benzamides, e.g., o-(3-phenylisoxazol-5-yl)-N-methylbenzamide, are prepared by cyclizing a corresponding 1-hydroxy-1-[substituted or unsubstituted -ଲ-(hydroxyimino)phenethyl]-2-alkyl phthalimidine with a stron... | 04/25/1978 |
| 4065462 | Iminoisoindolinone metal complex Iminoisoindolinone metal complexes of formula ##STR1## wherein A represents a 5- or 6-membered heterocyclic radical which contains at least one further heteroatom and can be fused or doubled with benzene nuclei, M represents a divalent metal atom exc... | 12/27/1977 |
| 4054577 | Preparation of aromatic bisimides Aromatic bisimides can be prepared by effecting reaction under anhydrous conditions between a 3- or 4-nitro-N-substituted phthalimide with an aromatic dihydroxy compound in the presence of a certain class of dipolar aprotic compounds as solvent and solid ... | 10/18/1977 |
| 4051177 | Process for the preparation of unsaturated amino compounds Process for the preparation of aromatic amines which additionally still contain C-C multiple bonds, characterized in that aromatic nitro compounds which still contain C-C multiple bonds are hydrogenated in the presence of cobalt sulphides as catalysts, at... | 09/27/1977 |
| 4021224 | Herbicide compositions Herbicidal compositions consisting of an active herbicidal compound and an antidote therefor and the methods of use of the herbicide composition are described herein. The antidote compound corresponds to the formula: ##STR1## wherein R can be selecte... | 05/03/1977 |
| 4020069 | Preparation of aromatic tetracarboxylic acids Aromatic tetracarboxylic acids can be prepared by effecting reaction between a 4-nitro-N-alkylphthalimide with an aromatic dihydroxy compound in the presence of potassium carbonate as a catalyst and using dimethyl sulfoxide as a solvent.... | 04/26/1977 |
| 4012372 | Phthalimidyl-azo-tetrahydro-quinoline compounds Monoazo compounds containing a phthalimidyl diazo component the aromatic ring of which can be substituted with one or two substituents, and the nitrogen of which may be substituted, and a 1,2,3,4-tetrahydroquinoline disperse azo dye coupling component whi... | 03/15/1977 |
| 4005102 | Process for making 4-nitro-n-methylphthalimide Nitrated derivatives of aromatic compounds are obtained by contacting the latter, in the presence of methylene chloride as a reaction medium, with concentrated nitric acid in the presence of concentrated sulfuric acid, and thereafter isolating the formed ... | 01/25/1977 |
