Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 6835212 | Agent and method for dyeing keratin fibers The agent for dyeing keratin fibers contains one or more aryl and/or benzyl alcohols, one or more oxidizing enzymes, especially vanillyl oxidase, derivatives of vanillyl oxidase or galactose oxidase, and a nucleophilic compound that forms a dye for dyeing keratin fi... | 12/28/2004 |
| 6821960 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorde... | 11/23/2004 |
| 6756500 | α,ω-Diene metathesis in the presence of ionic liquids A process for preparing a cyclic compound comprising subjecting a starting material in the presence of a catalyst component to metathesis reaction in the presence of an ionic liquid, wherein the starting material is a α,ω-diene bearing a α substituent NRR1 | 06/29/2004 |
| 6429212 | Medicinal composition It is to provide a cyclic imide derivative which is useful as an active ingredient of a pharmaceutical composition. A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): ##STR1## wherein Q | 08/06/2002 |
| 6294569 | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists A compound of the following formula: ##STR1## and the salts thereof, wherein A is hydrogen, halo, hydroxy, or the like; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 | 09/25/2001 |
| 6221877 | Substituted 4-phthalimidocarboxanilides as inhibitors of purine salvage phosphoribosyltransferases The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.... | 04/24/2001 |
| 6200967 | Anticoagulant agents This invention relates to a compound of the Formula I X--C(O)--Y--G--R I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or s... | 03/13/2001 |
| 6187931 | Process for making fluorophthalimides Tri- or tetrafluorophthalimides are produced in a halogen-exchange reaction utilizing a metal fluoride salt and a dihydrocarbyl sulfoxide as the solvent. No phase-transfer catalyst is employed. The process has been found capable of producing the fully flu... | 02/13/2001 |
| 6114156 | Molecular level coating for metal oxide particles Polymer encapsulated metal oxide particles are prepared by combining a polyamide acid in a polar aprotic solvent with a metal alkoxide solution. The polymer was imidized and the metal oxide formed simultaneously in a refluxing organic solvent. The resulti... | 09/05/2000 |
| 6103752 | Therapeutic heterocyclic compounds Compounds of formula (I) ##STR1## wherein R and R1 are hydrogen, C1-4 alkyl or are linked to form a ring, A is a cycloalkyl or alkyl-cycloalkyl group, n is an integer from 0 to 3, W is an optionally substituted 5- or 6-membered heter... | 08/15/2000 |
| 6087480 | Process for preparing sparingly soluble aromatic amines Preparation of sparingly soluble aromatic amines by catalytic hydrogenation of the corresponding aromatic nitro compounds in the presence of hydrogen, a solvent and a catalyst having a particle size of not less than 0.5 mm, wherein the aromatic nitro comp... | 07/11/2000 |
| 6066743 | Solventless preparation of phthalimides A method for the solventless synthesis of a phthalimide or phthalimide mixture is provided comprising contacting at least one amine reactant and at least one anhydride reactant in a solventless environment at a first temperature sufficient to allow the re... | 05/23/2000 |
| 6037476 | Process for making cyclic imides A process of producing cyclic imides from cyclic anhydrides is described. Despite the fact that an acid anhydride is reacted with a primary amine in the presence of both water and an acid, the reaction is materially unaffected by acid-catalyzed hydrolysis... | 03/14/2000 |
| 5994388 | Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis The present invention relates to inhibition of angiogenesis and the treatment of diseases mediated by angiogenesis. Particularly, the invention relates to the inhibition of neovascularization and the treatment of cancer. The invention further relates to t... | 11/30/1999 |
| 5936099 | Process for preparing BIS(ether anhydrides) using alkylamine derived bisimides having low melting temperature A process for making bis(ether anhydrides) employs alkylamines having low melting temperatures thus allowing for novel intermediate process steps for preparing bis(ether anhydrides). The alkylamines have alkyl groups which contain at least three carbon at... | 08/10/1999 |
| 5863915 | Substituted 4-arylbutyric acid derivatives as matrix metalloprotease Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein R... | 01/26/1999 |
| 5763465 | 7-(2-aminoethyl) benzothiazolones There are disclosed compounds of formula I, Ar--CH2 CH2 --NH--CR1 R2 --X--Y I in which Ar represents a group, ##STR1## X represents a C1-12 alkylene chain optionally interrupted or terminated b... | 06/09/1998 |
| 5719295 | Process for preparing bis(ether anhydrides) using alkylamine derived bisimides having low melting temperatures A process for making bis(ether anhydrides) employs alkylamines having low melting temperatures thus allowing for novel intermediate process steps for preparing bis(ether anhydrides). The alkylamines have alkyl groups which contain at least three carbon at... | 02/17/1998 |
| 5693797 | Process for preparing brominated phthalimides A process for the preparation of brominated phthalimides that involves mixing tetrabromophthalic anhydride, an organic acid, and an organic dispersing agent in water at approximately 110° C. under 1 bar pressure is disclosed. An amine is added and the re... | 12/02/1997 |
| 5605923 | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor Novel cyclohexene-ylidene derivatives of formula (I) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; they are also useful in... | 02/25/1997 |
| 5596104 | Preparation of 3,4,6-trifluorophthalic acid 3,4,6-trifluorophthalic acid is prepared in high yield by reaction of a 3,4,6-trichloro-N-substituted phthalimide with potassium fluoride at temperatures in the range of 200° to 270° C. in the absence of a catalyst to form the corresponding trifluoro-N-... | 01/21/1997 |
| 5440048 | 1-piperazinyl-2-butenes and -2-butynes Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.... | 08/08/1995 |
| 5359084 | Method of preparing aromatic ether bisimides A method for preparing an aromatic ether bisimide is provided. The mixture obtained from reacting a substituted phthalimide with a metal salt of a hydroxy aromatic compound in a non-polar solvent is extracted with about 4% to about 6% by weight aqueous al... | 10/25/1994 |
| 5294738 | Process for selective hydrodefluorination A process for the selective hydrodefluorination of a tetrafluorophthalimide compound of the formula ##STR1## where X is 1 and R is a monovalent organo group; or X is 2 and R is a divalent organo group; comprises reacting (I) the tetrafluorophthalimid... | 03/15/1994 |
| 5266587 | Peroxycarboxylic acids and compositions containing such The invention provides a new sub-class or organic peroxyacids comprising N-alkyl substituted peroxytrimellitimide of formula (I) in which R=hydrogen or linear or branched alkyl, which demonstrates an excellent combination of safe-handling and bleach perfo... | 11/30/1993 |
| 5252730 | Polymer composition having intense magnetic properties and method for preparation thereof A polymer composition having intense magnetic properties and a method for preparation of same. A phthalimide compound and an aromatic dialiphatic acid are reacted in the presence of a metal catalyst at elevated temperatures to form a phenylenebis diphthal... | 10/12/1993 |
| 5155231 | Process for preparation of 3,4,5,6- tetrahydrophthalimide Disclosed is a process for preparing 3,4,5,6-tetrahydrophthalimide comprising the steps of: (i) reacting a crude 3,4,5,6-tetrahydrophthalic anhydride containing as impurities at least one carboxylic anhydride (A) selected from the group consisting of phth... | 10/13/1992 |
| 5039823 | Method for preparing indoleninium halide Indoleninium halides, e.g., indoleninium iodides, are prepared by reacting the corresponding indolenine with an organic halide reactant, e.g., alkyl halide, such as methyl iodide, the organo portion of which undergoes addition to the nitrogen atom of the ... | 08/13/1991 |
| 4929613 | Antibacterial agents The novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation a... | 05/29/1990 |
| 4921970 | Nitration reactions with acid anhydride promoters An improved nitric acid only nitration process wherein the improvement comprises adding an effective amount of a nitration promoting acid anhydride to the reaction mixture to enhance the rate of nitration.... | 05/01/1990 |
| 4894187 | Flame resistant compositions and method of using same The invention relates to the preparation of halogenated imides derived from hydrazine and halogenated dicarboxylic acid anhydride and which can be used as flameproofing agents for plastics. The condensation of hydrazine and halogenated dicarboxylic acid a... | 01/16/1990 |
| 4837307 | [1,1'-biphenyl]compounds having a 2,2'-(alkyl)bridge and a 3-yl(substituted)methyl substituent A 2,2'-bridged[1,1'-biphenyl]-3-ylmethyl compound of the following formula is an intermediate to insecticidal esters. ##STR1## wherein n is 1-4 and Y is a leaving group readily displaced by carboxylate anions.... | 06/06/1989 |
| 4835272 | Process for formation of base and light-sensitive material A process for formation of a base, which comprises reacting an acetylide compound with a salt. The acetylide compound has the following formula: wherein R is a monovalent group selected from the group consisting of an alkyl group, a cycloalkyl group, an alkeny... | 05/30/1989 |
| 4780544 | Method for making oxybisphthalimides A method is provided for making oxybisphthalimides by heating an N-organonitrophthalimide in the presence of an aprotic organic solvent in an alkali metal carboxylate.... | 10/25/1988 |
| 4769493 | Process for producing tetrafluorophthalic acid A process for producing tetrafluorophthalic acid is disclosed, which comprises the steps of: (a) reacting an alkali metal fluoride and at least one imide compound represented by formula (I) or (II) ##STR1## wherein X1, X2, X | 09/06/1988 |
| 4711964 | Bisdiene from bis-benzocyclobutene compound Resins are prepared by polymerization of compounds of the formula ##STR1## where R is a divalent linking group. Blends of a compound of the formula (I) as defined above and a bis-maleimide of the formula ##STR2## where Ar' is an aromatic linking... | 12/08/1987 |
| 4681949 | Bis-aminopyridinium salts as phase transfer catalysts for aromatic ether imide preparation Novel bis-aminopyridinium salts are useful as phase transfer catalysts in the preparation of aromatic ethers by the reaction of hydroxyaromatic compound alkali metal salts (e.g., bisphenol A disodium salt) with activated halo- or nitro-substituted aromati... | 07/21/1987 |
| 4680412 | Preparation of fluorophthalimides Fluorophthalimides are prepared by a process in which a fluorophthalic anhydride is reacted, in the presence of an aliphatic sulfone, with from 0.4 to 0.8 mole of urea per mole of fluorophthalic anhydride, and the reaction is carried out first at 110°-14... | 07/14/1987 |
| 4623732 | Process for the preparation of N-alkylphthalimide and copolymer derived therefrom Compounds which are bis-(N-alkylphthalimides) are prepared by a new process in which a halogen-containing precursor is heated in the presence of a nickel compound, a reducing agent, for example, metallic zinc, and an organic solvent. The resulting compoun... | 11/18/1986 |
| 4609741 | Phthalic acid derivatives which are substituted by 2-propynyloxy groups, processes for their preparation and their use Novel phthalic acid derivatives are described which are substituted by 2-propynyloxy groups, of the formula I ##STR1## in which Q1, and Q2 independently of one another are --OH or --O- M+, or Q1 ... | 09/02/1986 |
