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| Number | Title | Issue Date |
| 7368608 | 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1,4-benzodioxane derivatives An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisti... | 05/06/2008 |
| 7223784 | Compounds for the modulation of the glycolysis enzyme and/or transaminase complex The invention relates to compounds for the modulation of the glycolysis enzyme complex and of the transaminase complex, pharmaceutical compositions containing such compounds as well as uses of such compounds for preparing pharmaceutical compositions for treating var... | 05/29/2007 |
| 7094908 | Reduction of carbonyl compounds using the carbonyl reductase of A compound represented by a general formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted β-keto ester and c... | 08/22/2006 |
| 7030201 | Bottom antireflective coatings The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions. ... | 04/18/2006 |
| 6918958 | Acid pigment dispersants and pigment preparations The invention relates to pigment dispersants of the formula (I), and to pigment preparations including at least one organic pigment and at least one pigment disperant of the formula (I): wherein Q1, R1 | 07/19/2005 |
| 6858738 | Process for making amlodipine, derivatives thereof, and precursors therefor Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provid... | 02/22/2005 |
| 6844359 | Substituted imides Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is (R)-2-Phthalimido-3-(3′,4′-dimethoxyphenyl)propane. ... | 01/18/2005 |
| 6756406 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 06/29/2004 |
| 6720429 | Thiocarbonylthio compound and living free radical polymerization using the same The present invention provides a thiocarbonylthio compound represented by formula (I) Wherein n is an integer of 0 to 3; R1 is alkyl, haloalkyl, alkenyl, aryl, alkylaryl, haloalkylaryl, arylalkyl, aminoalkyl, ... | 04/13/2004 |
| 6429221 | Substituted imides Novel imides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-Phthalimido-3-(3',4'-dimethoxyphenyl)propane.... | 08/06/2002 |
| 6380239 | Substituted 1-oxo- and 1,3-dioxoisoindoline and method of reducing inflammatory cytokine levels 1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.... | 04/30/2002 |
| 6365754 | Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives The present invention relates to a process for reacting -aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to syn... | 04/02/2002 |
| 6352958 | Cycloimido-substituted benzofused heterocyclic herbicides Novel herbicidal compounds, compositions containing them, and methods for their use in controlling weeds are disclosed. The novel herbicidal compounds are represented by formula I: ##STR1## where J is a 1-substituted-6-trifluoromethyl-2,4-pyrimidinedione-... | 03/05/2002 |
| 6348630 | Method for purifying hexamethylenediamine in mixtures of hexamethylenediamine and an unsaturated cyclic imine The level of an unsaturated cyclic imine (I) of the formula (I) ##STR1## where R1 is alkenyl having 3, 4, 5, 6, 7, 8, 9, 10, 11 carbon atoms belonging to the ring system, in a mixture comprising hexamethylenediamine and an imine (I) is reduced ... | 02/19/2002 |
| 6288063 | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)x A--B--D--E--G whe... | 09/11/2001 |
| 6221877 | Substituted 4-phthalimidocarboxanilides as inhibitors of purine salvage phosphoribosyltransferases The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.... | 04/24/2001 |
| 6211235 | Compounds for inhibiting ଲ-amyloid peptide release and/or its synthesis Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 04/03/2001 |
| 6211383 | Nohr-McDonald elimination reaction A reaction for eliminating a functional group alpha to a carbonyl group. The reaction can be used to dehydrate a compound having an alcohol group alpha to a carbonyl group by reacting the compound in a non-aqueous non-polar solvent in the presence of an e... | 04/03/2001 |
| 6069247 | Process for preparing substituted acrylamides by reaction of propiolamides and aromatic rings The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.... | 05/30/2000 |
| 6063924 | Soluble chromophores containing solubilising groups which can be easily removed Compounds of formula A(B)x (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxa... | 05/16/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6037367 | Substituted-pent-4-ynoic acids Compounds of formula (I) wherein: R1 is --(CR4 R5)n C(O)O(CR4 R5)m R6, --(CR4 R5)n C(O)NR4 (CR4 R5)m | 03/14/2000 |
| 6017471 | Colorants and colorant modifiers A light-stable colored composition which includes a colorant and a radiation transorber. The colorant, in the presence of the radiation transorber, is adapted, upon exposure of the transorber to specific, narrow bandwidth radiation, to be mutable. The rad... | 01/25/2000 |
| 6008268 | Photoreactor composition, method of generating a reactive species, and applications therefor A method of generating reactive species which includes exposing a photoreactor composition to radiation, in which the photoreactor composition comprises a wavelength-specific sensitizer associated with one or more reactive species-generating photoinitiato... | 12/28/1999 |
| 5965745 | Indole carbamates as leukotriene antagonists Compounds of the formula ##STR1## wherein R1 AND R2 are as defined, useful in the treatment of asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways diseases, psoriasis, allergic rhinitis, atopic ... | 10/12/1999 |
| 5939583 | Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## in which T is ... | 08/17/1999 |
| 5929217 | Reactive dyes with a benzo-fused heterocycle as anchor Reactive dyes of the formula I ##STR1## where a is 1 or 2, b is 0 or 1, Z1 is hydrogen, C1 -C6 -alkyl, C1 -C6 -alkoxy, halogen, nitro, amino, hydroxysulfonyl, C1 -C6 -alkoxycarbo... | 07/27/1999 |
| 5919949 | -hydroxy acid esters useful as intermediates in the production of ଲ-amino alcohols -Hydroxy acid esters of formula ##STR1## wherein R2 is lower-alkyl, useful as intermediates in the production of ଲ-aminoalcohols.... | 07/06/1999 |
| 5919948 | Asymmetric ligands useful for transition metal catalyzed bond forming reactions and epoxide reactions therewith A novel ligand having the Formula 1 structure has proved remarkably successful in the amination of butadiene monoepoxide, which is a potentially desirable substrate for an asymmetric synthesis providing access to each enantiomer of vinylglycinol. ##S... | 07/06/1999 |
| 5917038 | Process of preparing substituted acrylamides The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.... | 06/29/1999 |
| 5883284 | Method for producing -hydroxy-ଲ-aminocarboxylic acids The present invention provides a simple and inexpensive method for producing -hydroxy-ଲ-aminocarboxylic acids and their esters. An ester of an N-protected -amino acid ester is converted into a ଲ-ketosulfoxide, which is then processed ... | 03/16/1999 |
| 5861427 | Substituted 4-biarylbutyric acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T is... | 01/19/1999 |
| 5854277 | Thiophenebutanoic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T... | 12/29/1998 |
| 5852007 | Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/22/1998 |
| 5786132 | Pre-dyes, mutable dye compositions, and methods of developing a color One embodiment of the present invention is a method and composition comprising a novel pre-dye molecule that is colorless and stable to ordinary light. The pre-dye molecule is capable of forming a color when exposed to certain wavelengths of electromagnet... | 07/28/1998 |
| 5728845 | Immunotherapeutic nitriles Novel nitriles are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3-Phthalimido-3-(3,4-dimethoxyph... | 03/17/1998 |
| 5728844 | Immunotherapeutic agents Novel amides are inhibitors of TNF and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3-phthalimido-3-(3-cyclopentyloxy-4-methoxyphenyl)pro... | 03/17/1998 |
| 5658940 | Succinimide and maleimide cytokine inhibitors Novel succinimides and maleimides are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is methyl 3... | 08/19/1997 |
| 5637702 | Sulfur compounds Sulfur compounds of the formula ##STR1## where n is 0 or 2, R1 and R2 are hydrogen, C1 -C6 -alkyl, C1 -C6 -alkoxy, halogen, nitro, amino, hydroxysulfonyl, C1 -C6 ... | 06/10/1997 |
| 5610318 | Imidocarboxylic acid activators and sulfimidocarboxylic acid activators processes for their preparation and their use This invention is directed to a process for preparing a compound containing a persalt activators and salts thereof which are derived from imidocarboxylic acids and sulfimidocarboxylic acids of the formula I: ##STR1## in which A is a group of the form... | 03/11/1997 |
