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U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 8168804 | Large stoke shift NIR dyes A compound of the following formula: wherein R1 is SO3H; R2 is chosen from carboxylic acid group and SO3H; and R3 is chosen from Cl, carboxylic acid group, amino, amino... | 05/01/2012 |
| 8084621 | 3-Pyrrolo[]cyclohexylene-2-dihydroindolinone derivatives and uses thereof 3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmace... | 12/27/2011 |
| 7989638 | Conjugates of biological substances Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-... | 08/02/2011 |
| 7951959 | Hydrophilic labels for biomolecules Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labeling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diastereomeric cyanines with high hydro... | 05/31/2011 |
| 7943783 | Multifunctional amine capture agents Multifunctional compounds having acylsulfonamide amine-reactive groups are described that can be used for the capture of amine containing materials. ... | 05/17/2011 |
| 7928245 | Alcohols containing imide moieties and reactive oligomers prepared therefrom This invention relates to oligomeric compounds that are prepared by the reaction of a dianhydride with an amino-alcohol to yield an imide-diol intermediate, which is then esterified with a carboxylic acid to form a reactive oligomer. An exemplary reaction scheme is ... | 04/19/2011 |
| 7754893 | Conjugates of biological substances Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and the 3-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′... | 07/13/2010 |
| 7745640 | Hydrophilic labels for biomolecules Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydro... | 06/29/2010 |
| 7709660 | Polymethine ether compounds The invention provides novel compounds useful as intermediates for the production of polymethine compounds containing a desired counter ion with high purity and in high yields. Thus provided are polymethine ether compounds of the general formula (I) given bel... | 05/04/2010 |
| 7615646 | Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dymethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes ... | 11/10/2009 |
| 7495111 | Compounds useful as serotonin inhibitors and 5-HTagonists and antagonists 3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT1A receptor (agonizing or antagonizing) in a patient. These compounds are further useful ... | 02/24/2009 |
| 7446212 | Polymethine ethers The invention provides novel compounds useful as intermediates for the production of polymethine compounds containing a desired counter ion with high purity and in high yields. Thus provided are polymethine ether compounds of the general formula (I) given bel... | 11/04/2008 |
| 7417062 | Substituted arylamides Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer. ... | 08/26/2008 |
| 7402677 | Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives A TBET cassette including at least one xanthine- or pyronin-based compound as a donor or acceptor is disclosed. Also, a method of TBET cassette design in which four criteria may be used is provided. TBET cassettes may be used to label biological molecules, in clothi... | 07/22/2008 |
| 7388026 | Prodrugs of CC-1065 analogs Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the pr... | 06/17/2008 |
| 7375129 | Bis-indole pyrroles useful as antimicrobials agents Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-... | 05/20/2008 |
| 7348425 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 03/25/2008 |
| 7342119 | Process for the synthesis of a CPLAinhibitor A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound | 03/11/2008 |
| 7314932 | Methods for minimizing thioamide impurities Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrite groups, are provided. ... | 01/01/2008 |
| 7307095 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m... | 12/11/2007 |
| 7259213 | Indole resins epoxy resins and resin compositions containing the same This invention relates to epoxy resins containing indole as structural unit, indole resins and resin compositions containing said epoxy resins and indole resins useful for applications such as laminating, molding, casting and adhesion on account of their excellent f... | 08/21/2007 |
| 7253203 | Indoline derivatives This invention relates to substituted indoline derivative compounds which are antagonists of the progesterone receptor, their preparation and pharmaceutical utility, particularly including contraception and treatment of benign or malignant neoplastic diseases, havin... | 08/07/2007 |
| 7252815 | Pathological tissue detection and treatment employing targeted benzoindole optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and pho... | 08/07/2007 |
| 7244743 | Non-peptidic BRS-3 agonists Selectively BRS-3-agonistic compounds of formula I wherein A1, A2, A3, R1, R2, R3, Ar1, Ar2, Ar3, m and n have th... | 07/17/2007 |
| 7244607 | sp. nov. for control of insect pests Chromobacterium suttsuga sp. nov., a new species of the genus Chromobacterium which possesses insecticidal activity, is described. The invention also relates to insecticidally-active metabolites obtained from the strain and to insecticidal compositions... | 07/17/2007 |
| 7241897 | Process for preparing cyanine dye labeling reagents This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful ... | 07/10/2007 |
| 7232843 | Compositions containing C-substituted diindolylmethane compounds Disclosed are methods and compositions for the treatment of a wide array of cancers and tumors. In illustrative embodiments, diindolylmethanes, C-substituted diindolylmethanes, and analogs thereof have been described, which when administered either alone, or in comb... | 06/19/2007 |
| 7232906 | Substituted pyrrolines as kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ... | 06/19/2007 |
| 7214248 | Multi-component kit and method for temporarily dyeing and later decolorizing hair The composition for dyeing fibers is obtained before use by mixing a first component A1, containing at least one enamine of the formula (I) with a second component A2, containing at least one carbonyl compound. A... | 05/08/2007 |
| 7201892 | Pathological tissue detection and treatment employing targeted optical agents Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and pho... | 04/10/2007 |
| 7189721 | Bicyclic protein kinase inhibitors The present invention relates to novel 3-hetero-arylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase rel... | 03/13/2007 |
| 7172907 | Cyanine dye labelling reagents with -substitution Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): in which groups R3 and R4 are attached to the... | 02/06/2007 |
| 7173057 | Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 02/06/2007 |
| 7173051 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides m... | 02/06/2007 |
| 7166634 | Bis-indole pyrroles useful as antimicrobials agents Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-... | 01/23/2007 |
| 7157577 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions ... | 01/02/2007 |
| 7153852 | Indole compounds, process for producing the same and drugs containing the same as the active ingredient Indole derivatives represented by formula (I) wherein all symbols represent the same as that in specification), production methods thereof, and DP receptor antagonist comprising them as active ingredients. S... | 12/26/2006 |
| 7153848 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 12/26/2006 |
| 7148066 | Dye solutions for use in methods to detect the prior evaporation of anhydrous ammonia and the production of illict drugs Systems and methods providing for the introduction of a dye, particularly a xanthene dye, and more particularly a rhodamine dye, to liquid anhydrous ammonia to discourage theft of the anhydrous ammonia and provide for leak detection in storage vessels. The dye will ... | 12/12/2006 |
| 7148249 | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, ... | 12/12/2006 |
