Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 7423056 | Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoi... | 09/09/2008 |
| 7361680 | Indole compounds useful for the treatment of cancer The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. ... | 04/22/2008 |
| 7326475 | Material for organic electroluminescent device, organic electroluminescent device, illuminating device and display The present invention provides: an organic EL element exhibiting high luminance, a high external quantum efficiency and a long high temperature driving life at 50° C.; an illuminator and a display device employing the organic EL element; and a material preferably u... | 02/05/2008 |
| 7288561 | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a CNS disorder related to or affected by the 5-HT6 receptor ... | 10/30/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7241796 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to peptidomimetic compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3–NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as ... | 07/10/2007 |
| 7232842 | Kinase inhibitors and associated pharmaceutical compositions and methods of use The invention provides novel compounds useful as kinase inhibitors or as starting materials And/or intermediates in the synthesis of compounds useful as kinase inhibitors. The compounds have The general structure of formula (I) | 06/19/2007 |
| 7229986 | Melanin-concentrating hormone antagonist A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms... | 06/12/2007 |
| 7192977 | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, R1 preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is jo... | 03/20/2007 |
| 7153882 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof The present invention provides compounds and methods of administering compounds to a subject that can reduce βAPP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering s... | 12/26/2006 |
| 7129262 | Indole compounds useful for the treatment of cancer The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. ... | 10/31/2006 |
| 7087600 | Peptidyl prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 08/08/2006 |
| 7019003 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 03/28/2006 |
| 6989452 | Disulfide prodrugs and linkers and stabilizers useful therefor The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as ot... | 01/24/2006 |
| 6849767 | Method of hydroborating alcohols and reducing functional groups using a recyclable fluorous borane-sulfide A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide. ... | 02/01/2005 |
| 6815440 | Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course of which is invol... | 11/09/2004 |
| 6794455 | Coagents for fluoroelastomer free radical-curable compositions Crosslinking coagents based on aromatic diimides having N-substituted allyl groups are employed in place of triallyl isocyanurate (TAIC) for the free radical curing of fluoroelastomers. The diimide coagents mix more easily with fluoroelastomers and are less likely t... | 09/21/2004 |
| 6693111 | Indole-2,3-dione-3-oxime derivatives Indole-2,3-dione-3-oxime derivatives, for instance compounds represented by the formula ##STR1## are capable of antagonizing the effect of excitatory amino acids, such as glutamate. Also disclosed are methods of preparing the compounds, pharmaceutica... | 02/17/2004 |
| 6683105 | Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of Alzheimer's disease and dementias A method for treating cognitive impairments associated with aging or Alzheimer's disease which comprises treating a patient at risk for having the cognitive impairment with an effective amount of a highly selective butyrylcholinesterase inhibitor which is... | 01/27/2004 |
| 6605632 | Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them The invention concerns compounds of formula (I): R--A--R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the desc... | 08/12/2003 |
| 6586445 | ଲ-carboline compounds The present invention is directed to compounds of the formula ##STR1## wherein the variables are defined in the specification, which bind to somatostatin receptors and block Na channels.... | 07/01/2003 |
| 6586604 | Tricyclic amine derivatives The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an acti... | 07/01/2003 |
| 6495700 | Process for producing phenserine and its analog A process for preparing phenserine compounds which are known acetylcholinesterase inhibitors from physostigmine compounds by hydrolysis to form an eseroline compound which is then condensed with an isocyanate.... | 12/17/2002 |
| 6410747 | Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias A method for preventing or treating cognitive impairments associated with aging or Alzheimer's disease which comprises treating a patient at risk for having the cognitive impairment with an effective amount of a highly selective butyrylcholinesterase inhi... | 06/25/2002 |
| 6384050 | Tricyclic amine derivatives The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an acti... | 05/07/2002 |
| 6281354 | Analogs of duocarmycin and cc-1065 The field of this invention is antitumor antibiotics. More particularly, the present invention relates to analogs of duocarmycin and CC-1065, which analogs have antitumor antibiotics activity.... | 08/28/2001 |
| 6175014 | Process for the preparation of lactam derivatives The invention provides a process for the preparation of a compound of general formula (I): ##STR1## wherein Im represents an imidazolyl group of the formula: ##STR2## and R1 represents a hydrogen atom or a group as herein defined including... | 01/16/2001 |
| 6162822 | Bisimide compounds A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylam... | 12/19/2000 |
| 5998460 | Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N1-benzylnoreseroline: selective inhibitors of acetyl and butyrylcholinesterase, pharmaceutical compositions and method of use thereof The present invention relates to eseroline, N1 -noreseroline, and N1 -benzylnoreseroline phenyl carbamate analogues which provide highly potent and selective cholinergic agonist and blocking activity and their use as pharmaceutical a... | 12/07/1999 |
| 5919942 | Cyclohexane-1,2,4,5-diimide derivative and process for preparing the same The disclosure describes a cyclohexane-1,2,4,5-diimide derivative which can be used for the production of colorless transparent polymer and novel engineering plastics having good processability and solubility with an excellent physical property, and a pro... | 07/06/1999 |
| 5741814 | Cyclooctadiene derivatives Cyclooctadiene derivative of the following formula (1): ##STR1## wherein A1, A2, A3 and A4 each independently represent COOR5 (where R5 represents a hydrogen atom, a C1 -C10... | 04/21/1998 |
| 5734062 | Method of preparation of physostigmine carbamate derivatives from eseretholes This invention relates to a process for the preparation of a product of the formula ##STR1## wherein R is loweralkyl; R1 is hydrogen, loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, lowerbicycloalkyl, aryl or arylloweralkyl; Rs ... | 03/31/1998 |
| 5726323 | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R2 is hydrogen or alkyl or the group --NR1 R2 | 03/10/1998 |
| 5710281 | Organic compounds suitable as reactive diluents and binder precursor compositions including same Organic compounds having at least one ethylenically-unsaturated group are described, the organic compounds being suitable for use in coatable compositions as reactive diluents; compounds of the invention preferably have a divalent organic linking moiety d... | 01/20/1998 |
| 5709947 | Epoxy resins based on diaminobisimide compounds A method for the preparation of a diaminobisimide compound of the formula (I) substantially free of oligomers: ##STR1## wherein Ar1 is an optionally substituted aromatic residue which provides for good conjugation between the nitrogen cont... | 01/20/1998 |
| 5705657 | Isocyanate process for the preparation of 1,3A,8-trimethyl-1,2,3,3A, 8, 8A-hexahydro-pyrrole 2,3-B! indol-5 (3AS, 8AR) -hepthylcarbamate A process for the preparation of 1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrole2,3-b!indol-5(3aS,8aR)-he ptylcarbamate, of formula (I) ##STR1## by reacting eseroline with heptylisocyanate in the presence of a metal cyanate and of a quaternary... | 01/06/1998 |
| 5705509 | Tricyclic heterocyclic compounds as 5-HT4 receptor antagonists Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 --(CH2)x --X2 and the aromatic carbon atoms to which they are attached form 5-7 membered ring wherein X1 is O or S; X... | 01/06/1998 |
| 5693741 | Liquid molding compounds Low molecular weight resins that usually are aliphatic and that include crosslinking thermal functional groups are useful as liquid molding compounds for reaction injection molding or resin transfer molding. The compounds eliminate the need to handle solv... | 12/02/1997 |
| 5677457 | Method of preparation of physostigmine carbamate derivatives from eseroline ethers The present invention relates to a novel process for the preparation of physostigmine carbamate derivatives and to pharmaceutically acceptable salts thereof. The present invention further relates to a novel process for the preparation of eseroline derivat... | 10/14/1997 |
| 5665880 | Method of preparation of physostigmine carbamate derivatives from eseretholes This invention relates to a process for the preparation of a product of the formula ##STR1## wherein R is loweralkyl; R1, is hydrogen, loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, lowerbicycloalkyl, aryl or arylloweralyl; R... | 09/09/1997 |
