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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 8093403 | Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I); and a Reformatsky reagent in a stable form suitable for t... | 01/10/2012 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7300639 | Process for removing metals from liquids A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) wherein R1, R2, R3 | 11/27/2007 |
| 7297794 | Phenoxy amine compounds and compositions for delivering active agents Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 11/20/2007 |
| 7238212 | Imidazole compounds and use of these compounds for dyeing keratinous fibers The disclosure relates to novel imidazole compounds which can be useful as couplers for the oxidation dyeing of keratinous fibers. The present disclosure also relates to a dyeing composition for dyeing keratinous fibers comprising at least one oxidation base and at ... | 07/03/2007 |
| 7179925 | Method for reducing organic compounds in microreactor by means of hydrides and/or the derivatives thereof The present invention relates to a process for the reduction of aliphatic, aromatic or heterocyclic organic compounds by means of hydrides and/or derivatives thereof. ... | 02/20/2007 |
| 7164029 | Process for the preparation of benzylimidazole derivatives A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of losartan. ... | 01/16/2007 |
| 7074867 | Ion conducting polymers A compound having the general formula (I): −O3S—R1—V1—R2—V2 wherein R1 is a hydrocarbon radical comprising C1 to C10 | 07/11/2006 |
| 6979696 | Method for detecting a gram-negative bacterial autoinducer molecule This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein m, A, X, Y, R1, R2, R3,... | 12/27/2005 |
| 6958141 | Rhenium and technetium complexes containing a hypoxia-localizing moiety Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radion... | 10/25/2005 |
| 6951948 | Method for synthesis of substituted azole libraries The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components ... | 10/04/2005 |
| 6949578 | Cycloalkyl alkanoic acids as integrin receptor antagonists The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of select... | 09/27/2005 |
| 6943183 | 5-substituted tetralones as inhibitors of ras farnesyl transferase The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, ... | 09/13/2005 |
| 6933391 | Methods of synthesizing heteroatom-bearing ligands and intermediate used therefor The invention provides improved and simplified methods of synthesizing ligands containing a heteroatom-bearing bridge using a novel intermediate compound. The ligands may be used to form metal complexes that are useful in diagnostic and therapeutic applications.... | 08/23/2005 |
| 6927227 | Heterocyclic containing biphenyl aP2 inhibitors and method aP2 inhibiting compounds are provided having the formula wherein R1, R2, R3, R4, X—Z and are as described herein. A ... | 08/09/2005 |
| 6927232 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles This invention relates to the treatment of mGluR5 receptor mediated disorders, which comprises administering to a person in need of treatment a compound having the formula wherein R1, R2, R3 | 08/09/2005 |
| 6887871 | Use of phenylheteroakylamine derivatives There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the t... | 05/03/2005 |
| 6884821 | Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydro... | 04/26/2005 |
| 6737434 | Imidazole derivatives or their salts Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R1 is lower alkyl; R2 is alkyl or aralkyl; and X | 05/18/2004 |
| 6727238 | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated fi... | 04/27/2004 |
| 6706888 | Processes for preparing imidazole derivatives and salts thereof The present invention provides a process for preparing an imidazole derivative or its salt which comprises reacting a tetrahydrofuran or tetrahydropyran derivative with formamidine or its salt in the presence of a base. ... | 03/16/2004 |
| 6649643 | Imidazol-4-ylmehanols and their use as inhibitors of steroid C17-20 lyase Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometrios... | 11/18/2003 |
| 6630593 | Process for preparing a 1-substituted 5-hydroxymethyl imidazole A process for preparing a 1-substituted 5-hydroxymethylimidazole of the formula: ##STR1## , wherein R represents alkyl, hydroxyalkyl, allyl, or substituted or unsubstituted arylmethyl or diarylmethyl, comprising the step of reacting a 1-substituted ... | 10/07/2003 |
| 6545163 | Process to prepare 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers A process is disclosed for the preparation of imidazole derivatives, in particular, 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers, and more particular for the preparation of tioconazole. The preferred process involves alpha bromination of thiophene ... | 04/08/2003 |
| 6518257 | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof To provide a composition having a steroid C17,20 -lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: ##STR1## wherein R i... | 02/11/2003 |
| 6515133 | Pharmaceutical compositions containing certain diarylimidazole derivatives Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear aryl groups in the 2 position. Many of the compounds are nove... | 02/04/2003 |
| 6486156 | Chemical compounds This invention relates to compounds of formula (1), wherein substituents are defined in the description, that inhibit farnesylation of mutant ras gene products tough inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relate... | 11/26/2002 |
| 6479530 | Imidazole derivatives having affinity for 댒 receptors Imidazole derivatives of formula I ##STR1## wherein n is 0 or 1, R1 is hydrogen or C1 -C4 -alkyl, R2 is hydrogen or R2 and R3 together form a double bond, R3 is hydrogen or C | 11/12/2002 |
| 6459003 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administer... | 10/01/2002 |
| 6426360 | 4,5-substituted imidazolyl compounds for the treatment of inflammation A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, ... | 07/30/2002 |
| 6387892 | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme... | 05/14/2002 |
| 6384232 | Methods of synthesizing heteroatom-bearing ligands and intermediate used thereof The invention provides improved and simplified methods of synthesizing ligands containing a heteroatom-bearing bridge using a novel intermediate compound. The ligands may be used to form metal complexes that are useful in diagnostic and therapeutic applic... | 05/07/2002 |
| 6362211 | Polycyclic indanylimidazoles with alpha2 adrenergic activity A compound of formula I ##STR1## wherein R1 to R3, --A--, m and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha2 adrenergic agent.... | 03/26/2002 |
| 6362373 | Chiral amino alcohols and process for preparation of same The disclosed invention comprises a compound having the formula: ##STR1## in which R1 and R2 independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a process for the preparation of the... | 03/26/2002 |
| 6348482 | Catechols as antimicrobial agents Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: ##STR1## wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino... | 02/19/2002 |
| 6329371 | -substrates benzyl heterocyclic derivatives, intermediates for producing the same and agrochemical composition containing the same as active ingredient A compound represented by the formula (I): ##STR1## wherein R1 is an optionally substituted heterocyclic group; R2 is optionally substituted aryl or heterocyclic group; R3 is hydrogen, alkyl, alkenyl, or alkynyl; R4 | 12/11/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6265428 | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y are selected from groups that include O, S, and NH; and ... | 07/24/2001 |
| 6201123 | Catalyst composition, catalyst solution and process for preparing optically active epoxide A catalyst composition for organic a symmetric synthesis is provided, which comprises: (A) a lanthanoid element ion; (B) a binaphthol, and (C) a nitrogen and/or phosphorus compound such as lutidine-N-oxide, 1,3-dimethyl-2-imidazolldinone, hexamethyl-phosphortr... | 03/13/2001 |
| 6201001 | Imidazole antiproliferative agents Compounds of formula I ##STR1## inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.... | 03/13/2001 |
