Class 548/333.1 - Benzene ring bonded directly to the nitrogen

Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the nitrogen is bonded directly to a benzene
No. of patents: 84
Last issue date: 02/20/2007

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Number	Title	Issue Date
7179829	Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic, and medicament comprising them The invention relates to novel compounds of the type of the imidazolidines of the formula I in which R1 to R7 are as defined in the claims. They are used for preparing a medicament for the treatment or pr...	02/20/2007
7077873	Composition for the dyeing of human keratinous fibres comprising a monocationic monoazo dye A subject-matter of the disclosure is a novel composition for the dyeing of human keratinous fibres, for example, the hair, comprising a monocationic monoazo dye of formula (I) W1-N═N—W2-NW3-W4-W5, the dyeing processes employing it, the use of the dyes of formul...	07/18/2006
7078401	Thiophenylaminoimidazolines as IP antagonists Methods for treatment of IP antagonist mediated diseases or conditions by administration to a subject in need thereof a compound of formula (I) wherein R1, R2, A and X are as defined herein....	07/18/2006
7060806	Cationic azo dye compound The cationic dyes of formula (1) specified in claim 1 are suitable especially for colouring keratin-containing fibres, more especially for colouring hair. ...	06/13/2006
7019021	Compounds and methods for treating urinary incontinence Compounds of the formula (II) wherein R1, R2, R3, R4, and R5 are as set forth herein, pharmaceutical compositions containing them, and their use in treating urinary...	03/28/2006
6849634	Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described. ...	02/01/2005
6784183	Diphenylurea compounds Compounds of formula (I): and medicinal products containing the same which are useful as dual α2/5-HT2c antagonists. ...	08/31/2004
6777426	Imidazole and imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human α2 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where modulatio...	08/17/2004
6750238	Aralkyl ester soft drugs The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered. The parent drug comp...	06/15/2004
6737418	Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also i...	05/18/2004
6703409	2'-Halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine and the use thereof as a drug The present invention relates to 2'-halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine, the tautomeric 2'-halo-3',5'-dialkoxyanilino-2-imidazoline and/or the pharmacologically acceptable salts thereof and their use as pharmaceutical compositions....	03/09/2004
6632815	Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders....	10/14/2003
6602897	m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence A compound of formula I or of formula II ##STR1## wherein: R1 is F, Cl, Br, CH2 F, CF2 H, or CF3 ; R2 is NR6 R7, where R6 is Me, Et, Pr, or iPr, and R7 is Me, Et...	08/05/2003
6589972	ଲ-phenylalanine derivatives as integrin antagonists The present invention relates to compounds of the general formula (1) ##STR1## wherein R4 is --SO2 R4', --COOR4", --COR4', --CONR4'2 or --CSNR4'2 ; R4...	07/08/2003
6573288	Substituted sulphonyl cyanamides, method for producing same and their use as medicament The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or tr...	06/03/2003
6566387	IL-8 receptor antagonists The invention relates to the use of guanidine compounds in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8)....	05/20/2003
6509363	Heterocyclic inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides...	01/21/2003
6465650	Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids The invention provides a processes for the preparation of a compound of Formula I, or a salt thereof ##STR1## wherein PG is a urethane- or trityl-type protective group; X is NH, O, or S; Y is CH2, O, or NH; and B' is a base customary in nucleot...	10/15/2002
6417186	Substituted-phenyl ketone derivatives as IP antagonists This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor antagonists, and which are represented by Formula I: ##STR1## wherein A, R1 and R2 are as defined in the specification; and ...	07/09/2002
6395724	Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ...	05/28/2002
6294566	Imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human 댒 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease...	09/25/2001
6291503	ଲ-phenylalanine derivatives as integrin antagonists The present invention relates to compounds of the general formula (1) ##STR1## wherein R4 is --SO2 R4, --COOR4', --COR4', --CONR4'2 or --CSNR4'2 ; R4'...	09/18/2001
6268389	Treatment of urinary incontinence by administration of 댑L-adrenoceptor agonists The present invention relates to the use of ଱lL -agonists for treating urinary incontinence....	07/31/2001
6184242	2-(substituted-phenyl)amino-imidazoline derivatives This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: ##STR1## where: R1 is a group represented by formula (A), (B) or (C); ##STR2## and other substituents as defined in the specificati...	02/06/2001
6121303	Pharmacologically active catechol derivatives A compound of formula I ##STR1## wherein R1 is nitro, halogeno or cyano group and R2 is a group selected from ##STR2## wherein Y and Z are independently oxygen, sulfur or NR, wherein R is hydrogen, straight or branched...	09/19/2000
5922751	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-...	07/13/1999
5866579	Imidazole and imidazoline derivatives and uses thereof This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human 댒 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease...	02/02/1999
5684156	Process for preparation of clonidine derivatives A novel process for preparing clonidine derivatives has been discovered which is shorter, less expensive and safer than previously known methods. A new thiourea complex has also been discovered which can be directly cyclized to produce the corresponding h...	11/04/1997
5612364	Substantially pure apraclonidine Compositions containing, and methods for controlling intraocular pressure with, substantially pure apraclonidine are disclosed....	03/18/1997
5298659	Method for the preparation of azomethines Azomethines can be prepared by the condensation of cycloalkanones and anilines in the presence of acid homogeneous catalysts while the water of reaction is removed azeotropically, the condensation being carried out in a continuous reaction in a column-lik...	03/29/1994
5234917	Substituted 5-(alkyl)carboxamide imidazoles Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma pharmaceutical compositions including these antagonists, and me...	08/10/1993
5223498	Phenylamidine and phenylguanidine derivatives and their use as antidiabetic agents Compounds of formula I ##STR1## and their salts in which n=0 or 1, R1 and R2 are each aliphatic or cycloalkyl or NR1 R2 is an optionally substituted heterocyclic ring, R3 is alkyl, cycloalkyl or ...	06/29/1993
5141949	Method of providing anxiolytic and antipsychotic treatment Anxiolytic and antipsychotic treatment is provided to patients by administering therapeutically effective amounts of N-[2-(diethylamino)-ethyl]-2-methoxy-4-[(1-H-4,5-dihydro-2-imidazolyl)-ami no]-5-chlorobenzamide, or a pharmaceutically acceptable salt the...	08/25/1992
5059598	N-heterocyclo-substituted p-aminophenols Disclosed are compounds of the formula ##STR1## wherein: R1 is a lower alkyl group; R2 and R3 are each hydrogen or lower alkyl or R2 and R3 taken together may form --(CH2)4 -- or...	10/22/1991
4897397	Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed....	01/30/1990
4889868	Bis-imidazolinoamino derivatives as antiallergy compounds This invention relates to chemical compounds which possess valuable therapeutic activity particularly as lipoxygenase and phospholipase C inhibitors and as platelet-activating factor receptor antagonists. The compounds posses anti-inflammatory anti-asthma...	12/26/1989
4883649	Iodinated clonidine derivatives as radioactive imaging tracers Iodinated clonidine derivatives useful, inter alia, as a probe for identification and characterization of 댒 -adrenergic receptor sites and as tracers for imaging techniques such as positron emission tomography or computer assisted tomogr...	11/28/1989
4835172	Novel benzamides, intermediates and process for the preparation and therapeutic use thereof New substituted benzamides have the general formula: ##STR1## A=alkyl, alkenyl, diethylaminoethyl or ##STR2## R1, R2 =H, C1 -C6 alkyl, C2 -C6 alkenyl; R3, R4...	05/30/1989
4801617	Iminoimidazolidines useful in lowering intraocular pressure Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine ...	01/31/1989
4789681	Cytoprotective guanidine derivatives useful in ischemic diseases Compounds of the general formula I ##STR1## wherein R1 is hydrogen or methyl; R2 and R3, which are the same or different, represent hydrogen or methyl, or taken together, form the amidine system to which an imidazole ...	12/06/1988

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Class 548/333.1 - Benzene ring bonded directly to the nitrogen