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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 8022226 | Nonsedating α-2 agonists The present invention provides an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. The present invention further provides a pharmaceutical ... | 09/20/2011 |
| 7919630 | Synthesis of imidazole 2-thiones thiohydantoins The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione. ... | 04/05/2011 |
| 7868182 | Solventless one-step process for the production of imidazole-2-thiones A novel solventless process is described for the preparation of imidazole-2-thiones. The new solventless process tolerates a variety of bases as co-reactants which introduces feedstock flexibility into the process while the solventless feature renders the process mo... | 01/11/2011 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7419994 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 09/02/2008 |
| 7388098 | Dynamic resolution of isomers and resolved isomers Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution i... | 06/17/2008 |
| 7368467 | Ion channel modulators The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of ion channel function, and... | 05/06/2008 |
| 7312238 | Nonsedating α-2 agonists The present invention provides an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. The present invention further provides a pharmaceutical ... | 12/25/2007 |
| 7282592 | Resorcinol derivatives The present invention relates to certain resorcinol derivatives and their use as skin lightening agents. ... | 10/16/2007 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7223871 | Process for preparing substituted imidazole derivatives and intermediates used in the process The invention relates to a process for preparing substituted imidazole derivatives of formula (I) and acid addition salts thereof in which formula Y is —CH2— or —CO—, R1 is H, halo o... | 05/29/2007 |
| 7211671 | Substituted 1,3-dihydro-imidazol-2-one and 1,3-dihydro-imidazol-2-thione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present invention describes novel 1,3-dihydro-imidazol-2-one or 1,3-dihydro-imidazol-2-thione compounds of formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate thereof, wherein A, L R... | 05/01/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7141597 | Nonsedating α-2 agonists The present invention provides an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. The present invention further provi... | 11/28/2006 |
| 7115748 | Method of making imidazole-2-thiones The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione. ... | 10/03/2006 |
| 7091232 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic re... | 08/15/2006 |
| 7087764 | Process for producing arylsulfenyl halide A process for producing a compound of the formula (II): wherein Hal1 represents halogen and R1 and R2 each independently represents halogen, alkyl, alkoxy, nitro or cyano, which c... | 08/08/2006 |
| 6995294 | Method for producing bisphenol catalysts and bisphenols This disclosure relates to a method for producing and using catalysts in the production of bisphenols, and in particular to a method for producing catalysts which contain poly-sulfur mercaptan promoters, and using these catalysts in the production of bisphenol-A and... | 02/07/2006 |
| 6930076 | Nematicidal trifluorobutenyl imidazole thioether derivatives The present invention relates to novel trifluorobutenyl imidazole thioether derivatives of the following formula (I) wherein R1 represents hydrogen or halogen, ... | 08/16/2005 |
| 6730796 | Process for preparation of N-substituted 2-sulfanylimidazoles This invention provides a process for preparing an N-substituted 2-sulfanylimidazole compound of the formula (I) by reacting an isothiocyanate of the formula R1NCS with an α-aminocarbonyl compound of the form... | 05/04/2004 |
| 6635630 | Selective neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --S--, --SO--, ... | 10/21/2003 |
| 6627758 | Compositions and methods for hydration of terminal alkynes Compositions and methods are described for hydrating terminal alkynes catalytically in anti-Markovnikov fashion. The compositions comprise a transition metal complex including at least one organic ligand having at least two heteroatoms, wherein the hetero... | 09/30/2003 |
| 6573288 | Substituted sulphonyl cyanamides, method for producing same and their use as medicament The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or tr... | 06/03/2003 |
| 6562542 | Image-forming material and novel sulfonic acid ester derivative An image-forming material is described, comprising on an support an acid-generating agent selected from a sulfonic acid ester of a specific structure generating an acid by the action of heat and the polymer thereof, and a compound causing a light absorpti... | 05/13/2003 |
| 6552060 | Asymmetric disulfides and methods of using same The present invention is directed to a composition or formulation which includes an asymmetric disulfide which alone or in combination inhibits or interferes with cellular redox function, as well as a method of using same to restore normal cellular functi... | 04/22/2003 |
| 6528528 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis The present invention provides compounds of Formula I shown below. ##STR1## The present invention also provides methods of treating or preventing 3 inflammation or atherosclerosis, and a pharmaceutical composition that contains a compound of Formula I.... | 03/04/2003 |
| 6451736 | Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides compounds of the formula (I): ##STR1## wherein R1, R2, R3 and Z are as defined in the specification. The compounds are useful as herbicides.... | 09/17/2002 |
| 6426360 | 4,5-substituted imidazolyl compounds for the treatment of inflammation A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula ##STR1## wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, ... | 07/30/2002 |
| 6420384 | Proton pump inhibitors Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone targeting moiety and a payload. The payload portion of these inv... | 07/16/2002 |
| 6420613 | Process for preparing reductants of unsaturated organic compounds by the use of trichlorosilane and reducing agents A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced produc... | 07/16/2002 |
| 6403805 | 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatves The present invention describes compounds useful for treating warm-blooded animals suffering from disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase IV (PDE IV), and/or disease states related to a physiologically de... | 06/11/2002 |
| 6147097 | Imidazole derivatives as anti-HIV agents An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R1 represents hydrogen, C1 | 11/14/2000 |
| 6140508 | Process for making 1,5-disubstituted imidazoles The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.... | 10/31/2000 |
| 6114539 | Mercapto-imidazolyl derivatives The present invention provides mercapto-imidazolyl compounds, and the acid addition salts and metal salt complexes thereof; a process for their preparation; and a method for their use as microbicides.... | 09/05/2000 |
| 6107322 | Pesticidal 1-polyarylimidazoles A compound of formula (I): ##STR1## compositions containing them and methods of use to control pests.... | 08/22/2000 |
| 6090944 | Alkanoic acid derivatives as v integrin receptor antagonists The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors v댣, �... | 07/18/2000 |
| 6057352 | Fungicidal cyclic amides Compounds of Formula (I), ##STR1## and their N-oxides and agriculturally suitable salts are disclosed which are useful as fungicides, wherein E is 1,2-phenylene optionally substituted with one of R3, R4, or both R3 an... | 05/02/2000 |
| 6056965 | 2-mercapto-imidazole derivatives substituted in position 4 (or 5) as antioxidizing agents, method of preparation and applications in the pharmaceutical, cosmetic or food industries The invention relates to 2-mercaptoimidazole derivatives substituted in the 4(or 5)-position. These 2-mercaptoimidazole derivatives are of the general formula (I) below: ##STR1## wherein: R1, R2, R5, R7 and R | 05/02/2000 |
| 6040328 | Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use The objects of the present invention are: novel organoselenium compounds: aromatic diselenides and selenosulphides; the use of said novel compounds as antioxidant agents; pharmaceutical compositions containing them; a method of preparation of said novel compounds. Said ... | 03/21/2000 |
| 5994376 | 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one compounds and their use for treating allergic, atopic or inflammatory diseases The present invention describes 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one compounds and their use for treating warm-blooded animals suffering from disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase IV (PDE IV), ... | 11/30/1999 |
