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| Number | Title | Issue Date |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7390829 | Alpha-2 adrenergic agonists A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH2. Methods, compositions, and medicaments related thereto... | 06/24/2008 |
| 7265135 | 2-oxy, 2-amino, and 2-thio-imidazole compounds The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I): wherein all variables are as herein defined, pharmaceutical compositions containing the compo... | 09/04/2007 |
| 7125904 | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkyl... | 10/24/2006 |
| 7045532 | ACE-2 modulating compounds and methods of use thereof ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-Λ (I) Wherein Z is... | 05/16/2006 |
| 6884815 | High affinity small molecule C5a receptor modulators This invention relates to low molecular weight, non-peptidic, non-peptidomimetic, organic molecules that act as modulators of mammalian complement C5a receptors, preferably ones that act as high affinity C5a receptor ligands and also to such ligands that act as anta... | 04/26/2005 |
| 6627758 | Compositions and methods for hydration of terminal alkynes Compositions and methods are described for hydrating terminal alkynes catalytically in anti-Markovnikov fashion. The compositions comprise a transition metal complex including at least one organic ligand having at least two heteroatoms, wherein the hetero... | 09/30/2003 |
| 6362183 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid comp... | 03/26/2002 |
| 6288151 | Alkylated aminoalkyl cyclic urea surfactants Novel alkyl aminoalkyl cyclic urea compounds of the structural formula: ##STR1## wherein each of m, n, and o are independently 1 or 2, p is 0 or 1, R1 is C1 to C4 linear or branched alkyl, R2 is C4 to ... | 09/11/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6166220 | Ethylenically unsaturated imidazidolidinone monomers Classes of urea functional compounds and compositions containing the same are disclosed which are particularly suitable for use as a wet adhesion promoters in coatings, especially in aqueous emulsion systems used to make latex paints. Compositions contain... | 12/26/2000 |
| 6147097 | Imidazole derivatives as anti-HIV agents An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R1 represents hydrogen, C1 | 11/14/2000 |
| 6136983 | Pesticidal sulfur compounds Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining s... | 10/24/2000 |
| 6090944 | Alkanoic acid derivatives as v integrin receptor antagonists The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors v댣, �... | 07/18/2000 |
| 6060495 | Pesticidal sulfur compounds Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining s... | 05/09/2000 |
| 6056965 | 2-mercapto-imidazole derivatives substituted in position 4 (or 5) as antioxidizing agents, method of preparation and applications in the pharmaceutical, cosmetic or food industries The invention relates to 2-mercaptoimidazole derivatives substituted in the 4(or 5)-position. These 2-mercaptoimidazole derivatives are of the general formula (I) below: ##STR1## wherein: R1, R2, R5, R7 and R | 05/02/2000 |
| 6040328 | Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use The objects of the present invention are: novel organoselenium compounds: aromatic diselenides and selenosulphides; the use of said novel compounds as antioxidant agents; pharmaceutical compositions containing them; a method of preparation of said novel compounds. Said ... | 03/21/2000 |
| 6013200 | Low toxicity corrosion inhibitor A water soluble corrosion inhibitor containing a compound having at least one five-membered heterocyclic ring having at least one thione group and at least one other pendant group is described. Such a corrosion inhibiting compound can be made by reacting ... | 01/11/2000 |
| 5869515 | 1,3-dihydro-2H-imidazol-2-one compounds The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid or base addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 each independentl... | 02/09/1999 |
| 5852007 | Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/22/1998 |
| 5786373 | Fibrinogen receptor antagonists Novel fibrinogen receptor antagonists of the formula: X--Y--Z-Aryl-A--B and the pharmaceutically acceptable salts thereof, wherein Aryl is a 5-membered aromatic ring system containing 1 or 2 heteroatoms chosen from N, O or S wherein ring atoms may be unsu... | 07/28/1998 |
| 5780492 | Inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 07/14/1998 |
| 5719280 | Benzocycloalkylazolethione derivatives and processes for preparing the same The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine ଲ-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-te... | 02/17/1998 |
| 5643855 | Herbicidal imidazolones Compounds such as Formula I having herbicidal utility are disclosed: ##STR1## wherein Q is ##STR2## R1 is H; alkyl, haloalkyl or halogen R2 is C1 -C2 alkyl optionally substituted with one or more halog... | 07/01/1997 |
| 5618835 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.... | 04/08/1997 |
| 5612363 | N,N-di(aryl) cyclic urea derivatives as anti-coagulants N,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R1 is --C(NH)NH2, --C(NH)N(H)OR11, --C(NH)N(H)C(O)R9, or --C(NH)N(H)C(O)OR11 ; R2... | 03/18/1997 |
| 5578595 | Cyclopropylacetic acid derivatives Novel 2-(2,2-difluorocyclopropyl)-acetic acid derivatives of formula I ##STR1## wherein A is oxygen or --NR1 --, B is C2 -C6 alkylene, D is oxygen, sulfur or --O--CH2 --, E is phenyl; phenyl substituted by from one t... | 11/26/1996 |
| 5554633 | Substituted amines as tachykinin receptor antagonists Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H or C1-6 alkyl; R1 | 09/10/1996 |
| 5538988 | Benzocycloalkylazolethione derivatives The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine ଲ-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-te... | 07/23/1996 |
| 5536841 | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes A process for preparing 2-substituted 5-chloroimidazole-4-carbaldehydes of the general formula: ##STR1## In the process, a glycine ester hydrohalide is ring-closed with an imidate ester to obtain the intermediate 2-substituted 3,5-dihydroimidazol-4-o... | 07/16/1996 |
| 5496907 | Wet adhesion monomers with ureido functionality and polymers prepared therefrom Compounds containing a ureido group which are useful in preparing dispersions of polymers having good wet adhesion properties and low volatility. Compounds having the formula: ##STR1## where R1 is H or an alkyl group, R2 is alky... | 03/05/1996 |
| 5455243 | Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets Fibrinogen receptor antagonists of the formula: ##STR1## such as ##STR2## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.... | 10/03/1995 |
| 5455358 | Fuel compositions containing alkyl-substituted cyclic urea-substituted amines A fuel composition comprising a major amount of hydrocarbons boiling in the gasoline or diesel range and an effective detergent amount of an alkyl-substituted, five- or six-membered cyclic urea-substituted monoamine or diamine which is the reaction produc... | 10/03/1995 |
| 5451683 | Spatially-addressable immobilization of anti-ligands on surfaces Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces cover... | 09/19/1995 |
| 5444081 | Substituted histidines having angiotension II receptor antagonist activity Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 08/22/1995 |
| 5444080 | Substituted [1H-imidazol-5-ylialkanoic acids having angiotension II receptor antagonist activity Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and m... | 08/22/1995 |
| 5438150 | Process for making 1-benzocycloalkyl-1,3-dihydroimidazole-2-thione derivatives The present invention relates to a process for preparing a 5-(N-substituted)aminomethyl-1-benzocycloalkyl-1,3-dihydroimidazole-2-thio ne (wherein the N-substituent is selected from formyl, aminocarbonyl, (C1-4)alkylcarbonyl or trifluoro (C1... | 08/01/1995 |
| 5424450 | Angiotensin II receptor blocking imidazolinone derivatives Novel imidazolinone derivatives of formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##... | 06/13/1995 |
| 5405873 | Substituted acetamide derivatives There are provided substituted acetamide derivatives represented by general formula (I): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 | 04/11/1995 |
| 5399706 | Imidazolidinone diamine and derivatives thereof Imidazolidinone compounds of the formula: ##STR1## where R is a C3 -C5 alkylene group, R1 and R2 are independently H or C(.dbd.O)R4, R3 is an aliphatic hydrocarbon group optionally sub... | 03/21/1995 |
